VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected Patients
Background: Vitamin D is a fundamental regulator of host defenses by activating genes related to innate and adaptive immunity. In this study, we analyzed the association among single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene, with clinical patterns of AIDS progression in a...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL) |
| Repositorio: | r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante |
| OAI Identifier: | oai:isabial.fundanetsuite.com:p8024 |
| Acceso en línea: | https://isabial.portalinvestigacion.com/publicaciones8024 |
| Access Level: | acceso abierto |
| Palabra clave: | single nucleotide polymorphisms VDR LTNPs AIDS non-progression |
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ES_1919e18eed4cc4b01a35701b5c191669 |
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oai:isabial.fundanetsuite.com:p8024 |
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| dc.title.none.fl_str_mv |
VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected Patients |
| title |
VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected Patients |
| spellingShingle |
VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected Patients Jimenez-Sousa, MA single nucleotide polymorphisms VDR LTNPs AIDS non-progression |
| title_short |
VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected Patients |
| title_full |
VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected Patients |
| title_fullStr |
VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected Patients |
| title_full_unstemmed |
VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected Patients |
| title_sort |
VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected Patients |
| dc.creator.none.fl_str_mv |
Jimenez-Sousa, MA Jimenez, JL Fernandez-Rodriguez, A Brochado-Kith, O Bellon, JM Bernal-Morell, E Munoz-Fernandez, MA Resino, S del Amo, J Navarro, ML Gonzalez, MI Blanco, JL Gonzalez, J Del Amo, J Jarrin, I Alejos, B Hernando, V Moreno, C Iniesta, C Sousa, LMG Perez, NS Munoz-Fernandez, MA Garcia-Merino, IM Fernandez, IC Rico, CG de la Fuente, JG Concejo, PP Portilla, J Merino, E Reus, S Boix, V Giner, L Gadea, C Portilla, I Pampliega, M Diez, M Rodriguez, JC Sanchez-Paya, J Gomez, JL Hernandez, J Aleman, MR Alonso, MD Hernandez, MI Diaz-Flores, F Garcia, D Pelazas, R Lirola, AL Rubio, R Pulido, F Bisbal, O Hernando, A Dominguez, L Crestelo, DR Bermejo, L Santacreu, M Iribarren, JA Arrizabalaga, J Aramburu, MJ Camino, X Rodriguez-Arrondo, F von Wichmann, MA Tome, LP Goenaga, MA Bustinduy, MJ Azkune, H Ibarguren, M Lizardi, A Kortajarena, X Gutierrez, F Masia, M Padilla, S Navarro, A Montolio, F Robledano, C Colome, JG Adsuar, A Pascual, R Fernandez, M Garcia, E Garcia, JA Barber, X Berenguer, J de Quiros, JCLB Gutierrez, I Ramirez, M Padilla, B Gijon, P Aldamiz-Echevarria, T Tejerina, F Parras, FJ Balsalobre, P Diez, C Latorre, LP Vidal, F Peraire, J Vilades, C Veloso, S Vargas, M Lopez-Dupla, M Olona, M Rull, A Rodriguez-Gallego, E Alba, V Alonso, MM Aldeguer, JL Julia, MB Pitarch, MT Hernandez, IC Munoz, EC Tovar, SC Lleti, MS Navarro, JF Gonzalez-garcia, J Arnalich, F Arribas, JR de la Serna, JIB Castro, JM Escosa, L Herranz, P Hontanon, V Garcia-Bujalance, S Lopez-Hortelano, MG Gonzalez-Baeza, A Martin-Carbonero, ML Mayoral, M Mellado, MJ Mican, RE Montejano, R Montes, ML Moreno, V Perez-Valero, I Rodes, B Sainz, T Sendagorta, E Alcariz, NS Valencia, E Blanco, JR Oteo, JA Ibarra, V Metola, L Sanz, M Perez-Martinez, L Dalmau, D Jaen, A Sanmarti, M Cairo, M Martinez-Lacasa, J Velli, P Font, R Xercavins, M Alonso, N Rivero, M Reparaz, J de Alda, MGR Cano, MTD de Galarreta, BPR Segura, F Amengual, MJ Navarro, G Sala, M Cervantes, M Pineda, V Calzado, S Navarro, M de los Santos, I Sanz, JS Aparicio, AS Cepeda, CS Fraile, LGF Gayo, EM Moreno, S Casado, JL Dronda, F Moreno, A Elias, MJP Ayerbe, CG Gutierrez, C Madrid, N Terron, SD Marti, P Ansa, U Serrano, S Vivancos, MJ Bernal, E Cano, A Garcia, AA Urbieta, JB Munoz, A Alcaraz, MJ Villalba, MD Garcia, F Hernandez, J Pena, A Munoz, L Casas, P Alvarez, M Chueca, N Vinuesa, D Martinez-Montes, C Del Romero, J Rodriguez, C Puerta, T Carrio, JC Vera, M Ballesteros, J Ayerdi, O Riera, M Penaranda, M Leyes, M Ribas, MA Campins, AA Vidal, C Fanjul, F Murillas, J Homar, F Santos, J Ayerbe, CG Viciana, I Palacios, R Gonzalez, CM Viciana, P Espinosa, N Lopez-Cortes, LF Podzamczer, D Ferrer, E Imaz, A Tiraboschi, J Silva, A Saumoy, M Olalla, J del Arco, A de la Torre, J Prada, JL Guerrero, JMGD Stachowski, JP Martinez, OJ Vera, FJ Martinez, L Garcia, J Alcaraz, B Jimeno, A Iglesias, AC Souto, BP de Cea, AM Galera, C Albendin, H Perez, A Iborra, A Moreno, A Merlos, MA Vidal, A Suarez-Garcia, I Malmierca, E Gonzalez-Ruano, P Rodrigo, DM Mohamed-Balghata, MO Vidal, MAG Perez, VE Molina, MJT Garcia, JV Moreno, JPS Gorgolas, M Cabello, A Alvarez, B Prieto, L Moreno, JS Caso, AA Gutierrez, CH Mena, MN Puerto, MJG Vilalta, RF Ribera, AF Roman, AR Herrero, MTB Juarez, AR Lopez, PL Sanchez, IM Martinez, JP Jimenez, MC Perea, RT Ruiz-Capillas, JJJ Pineda, JA CoRIS Spanish HIV HGM BioBank LTNPs Cohort |
| author |
Jimenez-Sousa, MA |
| author_facet |
Jimenez-Sousa, MA Jimenez, JL Fernandez-Rodriguez, A Brochado-Kith, O Bellon, JM Bernal-Morell, E Munoz-Fernandez, MA Resino, S del Amo, J Navarro, ML Gonzalez, MI Blanco, JL Gonzalez, J Del Amo, J Jarrin, I Alejos, B Hernando, V Moreno, C Iniesta, C Sousa, LMG Perez, NS Garcia-Merino, IM Fernandez, IC Rico, CG de la Fuente, JG Concejo, PP Portilla, J Merino, E Reus, S Boix, V Giner, L Gadea, C Portilla, I Pampliega, M Diez, M Rodriguez, JC Sanchez-Paya, J Gomez, JL Hernandez, J Aleman, MR Alonso, MD Hernandez, MI Diaz-Flores, F Garcia, D Pelazas, R Lirola, AL Rubio, R Pulido, F Bisbal, O Hernando, A Dominguez, L Crestelo, DR Bermejo, L Santacreu, M Iribarren, JA Arrizabalaga, J Aramburu, MJ Camino, X Rodriguez-Arrondo, F von Wichmann, MA Tome, LP Goenaga, MA Bustinduy, MJ Azkune, H Ibarguren, M Lizardi, A Kortajarena, X Gutierrez, F Masia, M Padilla, S Navarro, A Montolio, F Robledano, C Colome, JG Adsuar, A Pascual, R Fernandez, M Garcia, E Garcia, JA Barber, X Berenguer, J de Quiros, JCLB Gutierrez, I Ramirez, M Padilla, B Gijon, P Aldamiz-Echevarria, T Tejerina, F Parras, FJ Balsalobre, P Diez, C Latorre, LP Vidal, F Peraire, J Vilades, C Veloso, S Vargas, M Lopez-Dupla, M Olona, M Rull, A Rodriguez-Gallego, E Alba, V Alonso, MM Aldeguer, JL Julia, MB Pitarch, MT Hernandez, IC Munoz, EC Tovar, SC Lleti, MS Navarro, JF Gonzalez-garcia, J Arnalich, F Arribas, JR de la Serna, JIB Castro, JM Escosa, L Herranz, P Hontanon, V Garcia-Bujalance, S Lopez-Hortelano, MG Gonzalez-Baeza, A Martin-Carbonero, ML Mayoral, M Mellado, MJ Mican, RE Montejano, R Montes, ML Moreno, V Perez-Valero, I Rodes, B Sainz, T Sendagorta, E Alcariz, NS Valencia, E Blanco, JR Oteo, JA Ibarra, V Metola, L Sanz, M Perez-Martinez, L Dalmau, D Jaen, A Sanmarti, M Cairo, M Martinez-Lacasa, J Velli, P Font, R Xercavins, M Alonso, N Rivero, M Reparaz, J de Alda, MGR Cano, MTD de Galarreta, BPR Segura, F Amengual, MJ Navarro, G Sala, M Cervantes, M Pineda, V Calzado, S Navarro, M de los Santos, I Sanz, JS Aparicio, AS Cepeda, CS Fraile, LGF Gayo, EM Moreno, S Casado, JL Dronda, F Moreno, A Elias, MJP Ayerbe, CG Gutierrez, C Madrid, N Terron, SD Marti, P Ansa, U Serrano, S Vivancos, MJ Bernal, E Cano, A Garcia, AA Urbieta, JB Munoz, A Alcaraz, MJ Villalba, MD Garcia, F Pena, A Munoz, L Casas, P Alvarez, M Chueca, N Vinuesa, D Martinez-Montes, C Del Romero, J Rodriguez, C Puerta, T Carrio, JC Vera, M Ballesteros, J Ayerdi, O Riera, M Penaranda, M Leyes, M Ribas, MA Campins, AA Vidal, C Fanjul, F Murillas, J Homar, F Santos, J Viciana, I Palacios, R Gonzalez, CM Viciana, P Espinosa, N Lopez-Cortes, LF Podzamczer, D Ferrer, E Imaz, A Tiraboschi, J Silva, A Saumoy, M Olalla, J del Arco, A de la Torre, J Prada, JL Guerrero, JMGD Stachowski, JP Martinez, OJ Vera, FJ Martinez, L Garcia, J Alcaraz, B Jimeno, A Iglesias, AC Souto, BP de Cea, AM Galera, C Albendin, H Perez, A Iborra, A Merlos, MA Vidal, A Suarez-Garcia, I Malmierca, E Gonzalez-Ruano, P Rodrigo, DM Mohamed-Balghata, MO Vidal, MAG Perez, VE Molina, MJT Garcia, JV Moreno, JPS Gorgolas, M Cabello, A Alvarez, B Prieto, L Moreno, JS Caso, AA Gutierrez, CH Mena, MN Puerto, MJG Vilalta, RF Ribera, AF Roman, AR Herrero, MTB Juarez, AR Lopez, PL Sanchez, IM Martinez, JP Jimenez, MC Perea, RT Ruiz-Capillas, JJJ Pineda, JA CoRIS Spanish HIV HGM BioBank LTNPs Cohort |
| author_role |
author |
| author2 |
Jimenez, JL Fernandez-Rodriguez, A Brochado-Kith, O Bellon, JM Bernal-Morell, E Munoz-Fernandez, MA Resino, S del Amo, J Navarro, ML Gonzalez, MI Blanco, JL Gonzalez, J Del Amo, J Jarrin, I Alejos, B Hernando, V Moreno, C Iniesta, C Sousa, LMG Perez, NS Garcia-Merino, IM Fernandez, IC Rico, CG de la Fuente, JG Concejo, PP Portilla, J Merino, E Reus, S Boix, V Giner, L Gadea, C Portilla, I Pampliega, M Diez, M Rodriguez, JC Sanchez-Paya, J Gomez, JL Hernandez, J Aleman, MR Alonso, MD Hernandez, MI Diaz-Flores, F Garcia, D Pelazas, R Lirola, AL Rubio, R Pulido, F Bisbal, O Hernando, A Dominguez, L Crestelo, DR Bermejo, L Santacreu, M Iribarren, JA Arrizabalaga, J Aramburu, MJ Camino, X Rodriguez-Arrondo, F von Wichmann, MA Tome, LP Goenaga, MA Bustinduy, MJ Azkune, H Ibarguren, M Lizardi, A Kortajarena, X Gutierrez, F Masia, M Padilla, S Navarro, A Montolio, F Robledano, C Colome, JG Adsuar, A Pascual, R Fernandez, M Garcia, E Garcia, JA Barber, X Berenguer, J de Quiros, JCLB Gutierrez, I Ramirez, M Padilla, B Gijon, P Aldamiz-Echevarria, T Tejerina, F Parras, FJ Balsalobre, P Diez, C Latorre, LP Vidal, F Peraire, J Vilades, C Veloso, S Vargas, M Lopez-Dupla, M Olona, M Rull, A Rodriguez-Gallego, E Alba, V Alonso, MM Aldeguer, JL Julia, MB Pitarch, MT Hernandez, IC Munoz, EC Tovar, SC Lleti, MS Navarro, JF Gonzalez-garcia, J Arnalich, F Arribas, JR de la Serna, JIB Castro, JM Escosa, L Herranz, P Hontanon, V Garcia-Bujalance, S Lopez-Hortelano, MG Gonzalez-Baeza, A Martin-Carbonero, ML Mayoral, M Mellado, MJ Mican, RE Montejano, R Montes, ML Moreno, V Perez-Valero, I Rodes, B Sainz, T Sendagorta, E Alcariz, NS Valencia, E Blanco, JR Oteo, JA Ibarra, V Metola, L Sanz, M Perez-Martinez, L Dalmau, D Jaen, A Sanmarti, M Cairo, M Martinez-Lacasa, J Velli, P Font, R Xercavins, M Alonso, N Rivero, M Reparaz, J de Alda, MGR Cano, MTD de Galarreta, BPR Segura, F Amengual, MJ Navarro, G Sala, M Cervantes, M Pineda, V Calzado, S Navarro, M de los Santos, I Sanz, JS Aparicio, AS Cepeda, CS Fraile, LGF Gayo, EM Moreno, S Casado, JL Dronda, F Moreno, A Elias, MJP Ayerbe, CG Gutierrez, C Madrid, N Terron, SD Marti, P Ansa, U Serrano, S Vivancos, MJ Bernal, E Cano, A Garcia, AA Urbieta, JB Munoz, A Alcaraz, MJ Villalba, MD Garcia, F Pena, A Munoz, L Casas, P Alvarez, M Chueca, N Vinuesa, D Martinez-Montes, C Del Romero, J Rodriguez, C Puerta, T Carrio, JC Vera, M Ballesteros, J Ayerdi, O Riera, M Penaranda, M Leyes, M Ribas, MA Campins, AA Vidal, C Fanjul, F Murillas, J Homar, F Santos, J Viciana, I Palacios, R Gonzalez, CM Viciana, P Espinosa, N Lopez-Cortes, LF Podzamczer, D Ferrer, E Imaz, A Tiraboschi, J Silva, A Saumoy, M Olalla, J del Arco, A de la Torre, J Prada, JL Guerrero, JMGD Stachowski, JP Martinez, OJ Vera, FJ Martinez, L Garcia, J Alcaraz, B Jimeno, A Iglesias, AC Souto, BP de Cea, AM Galera, C Albendin, H Perez, A Iborra, A Merlos, MA Vidal, A Suarez-Garcia, I Malmierca, E Gonzalez-Ruano, P Rodrigo, DM Mohamed-Balghata, MO Vidal, MAG Perez, VE Molina, MJT Garcia, JV Moreno, JPS Gorgolas, M Cabello, A Alvarez, B Prieto, L Moreno, JS Caso, AA Gutierrez, CH Mena, MN Puerto, MJG Vilalta, RF Ribera, AF Roman, AR Herrero, MTB Juarez, AR Lopez, PL Sanchez, IM Martinez, JP Jimenez, MC Perea, RT Ruiz-Capillas, JJJ Pineda, JA CoRIS Spanish HIV HGM BioBank LTNPs Cohort |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
single nucleotide polymorphisms VDR LTNPs AIDS non-progression |
| topic |
single nucleotide polymorphisms VDR LTNPs AIDS non-progression |
| description |
Background: Vitamin D is a fundamental regulator of host defenses by activating genes related to innate and adaptive immunity. In this study, we analyzed the association among single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene, with clinical patterns of AIDS progression in antiretroviral treatment (ART)-naive HIV-infected patients. Methods: We conducted a retrospective study in 667 HIV-infected patients, who were classified within three groups according to their AIDS progression pattern (183 long-term non-progressors (LTNPs), 334 moderate progressors (MPs), and 150 rapid progressors (RPs)). Five VDR SNPs (rs11568820, rs4516035, rs2228570, rs1544410, and rs7975232) were genotyped using Agena Bioscience's MassARRAY platform. Results: Significant association results were found for rs2228570. Within all HIV patients, the presence of T allele at VDR rs2228570 SNP was protective against AIDS progression (ordinal outcome) under additive (adjusted odds ratio (aOR) = 0.75; p = 0.009), dominant (aOR = 0.69; p = 0.015), and codominant (aOR = 0.56; p = 0.017) inheritance models. In addition, the same allele was protective under additive and codominant inheritance models when we compared with LTNPs vs. RPs [aOR = 0.64 (p = 0.019) and aOR = 0.37 (p = 0.018), respectively] and when we compared MPs vs. RPs [aOR = 0.72 (p = 0.035) and aOR = 0.45 (p = 0.028), respectively]. Conclusions: The VDR rs2228570 T allele was related to a lower AIDS progression pattern in ART-naive HIV-infected patients. These findings expand upon the knowledge about HIV pathogenesis in untreated HIV-infected patients with different clinical outcomes. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://isabial.portalinvestigacion.com/publicaciones8024 |
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https://isabial.portalinvestigacion.com/publicaciones8024 |
| dc.language.none.fl_str_mv |
Inglés |
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Inglés |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
| dc.publisher.none.fl_str_mv |
MDPI |
| publisher.none.fl_str_mv |
MDPI |
| dc.source.none.fl_str_mv |
Journal of Clinical Medicine ISSN: 20770383 reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL) |
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Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL) |
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r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante |
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r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante |
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1869404025663782912 |
| spelling |
VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected PatientsJimenez-Sousa, MAJimenez, JLFernandez-Rodriguez, ABrochado-Kith, OBellon, JMBernal-Morell, EMunoz-Fernandez, MAResino, Sdel Amo, JNavarro, MLGonzalez, MIBlanco, JLGonzalez, JDel Amo, JJarrin, IAlejos, BHernando, VMoreno, CIniesta, CSousa, LMGPerez, NSMunoz-Fernandez, MAGarcia-Merino, IMFernandez, ICRico, CGde la Fuente, JGConcejo, PPPortilla, JMerino, EReus, SBoix, VGiner, LGadea, CPortilla, IPampliega, MDiez, MRodriguez, JCSanchez-Paya, JGomez, JLHernandez, JAleman, MRAlonso, MDHernandez, MIDiaz-Flores, FGarcia, DPelazas, RLirola, ALRubio, RPulido, FBisbal, OHernando, ADominguez, LCrestelo, DRBermejo, LSantacreu, MIribarren, JAArrizabalaga, JAramburu, MJCamino, XRodriguez-Arrondo, Fvon Wichmann, MATome, LPGoenaga, MABustinduy, MJAzkune, HIbarguren, MLizardi, AKortajarena, XGutierrez, FMasia, MPadilla, SNavarro, AMontolio, FRobledano, CColome, JGAdsuar, APascual, RFernandez, MGarcia, EGarcia, JABarber, XBerenguer, Jde Quiros, JCLBGutierrez, IRamirez, MPadilla, BGijon, PAldamiz-Echevarria, TTejerina, FParras, FJBalsalobre, PDiez, CLatorre, LPVidal, FPeraire, JVilades, CVeloso, SVargas, MLopez-Dupla, MOlona, MRull, ARodriguez-Gallego, EAlba, VAlonso, MMAldeguer, JLJulia, MBPitarch, MTHernandez, ICMunoz, ECTovar, SCLleti, MSNavarro, JFGonzalez-garcia, JArnalich, FArribas, JRde la Serna, JIBCastro, JMEscosa, LHerranz, PHontanon, VGarcia-Bujalance, SLopez-Hortelano, MGGonzalez-Baeza, AMartin-Carbonero, MLMayoral, MMellado, MJMican, REMontejano, RMontes, MLMoreno, VPerez-Valero, IRodes, BSainz, TSendagorta, EAlcariz, NSValencia, EBlanco, JROteo, JAIbarra, VMetola, LSanz, MPerez-Martinez, LDalmau, DJaen, ASanmarti, MCairo, MMartinez-Lacasa, JVelli, PFont, RXercavins, MAlonso, NRivero, MReparaz, Jde Alda, MGRCano, MTDde Galarreta, BPRSegura, FAmengual, MJNavarro, GSala, MCervantes, MPineda, VCalzado, SNavarro, Mde los Santos, ISanz, JSAparicio, ASCepeda, CSFraile, LGFGayo, EMMoreno, SCasado, JLDronda, FMoreno, AElias, MJPAyerbe, CGGutierrez, CMadrid, NTerron, SDMarti, PAnsa, USerrano, SVivancos, MJBernal, ECano, AGarcia, AAUrbieta, JBMunoz, AAlcaraz, MJVillalba, MDGarcia, FHernandez, JPena, AMunoz, LCasas, PAlvarez, MChueca, NVinuesa, DMartinez-Montes, CDel Romero, JRodriguez, CPuerta, TCarrio, JCVera, MBallesteros, JAyerdi, ORiera, MPenaranda, MLeyes, MRibas, MACampins, AAVidal, CFanjul, FMurillas, JHomar, FSantos, JAyerbe, CGViciana, IPalacios, RGonzalez, CMViciana, PEspinosa, NLopez-Cortes, LFPodzamczer, DFerrer, EImaz, ATiraboschi, JSilva, ASaumoy, MOlalla, Jdel Arco, Ade la Torre, JPrada, JLGuerrero, JMGDStachowski, JPMartinez, OJVera, FJMartinez, LGarcia, JAlcaraz, BJimeno, AIglesias, ACSouto, BPde Cea, AMGalera, CAlbendin, HPerez, AIborra, AMoreno, AMerlos, MAVidal, ASuarez-Garcia, IMalmierca, EGonzalez-Ruano, PRodrigo, DMMohamed-Balghata, MOVidal, MAGPerez, VEMolina, MJTGarcia, JVMoreno, JPSGorgolas, MCabello, AAlvarez, BPrieto, LMoreno, JSCaso, AAGutierrez, CHMena, MNPuerto, MJGVilalta, RFRibera, AFRoman, ARHerrero, MTBJuarez, ARLopez, PLSanchez, IMMartinez, JPJimenez, MCPerea, RTRuiz-Capillas, JJJPineda, JACoRISSpanish HIV HGM BioBankLTNPs Cohortsingle nucleotide polymorphismsVDRLTNPsAIDSnon-progressionBackground: Vitamin D is a fundamental regulator of host defenses by activating genes related to innate and adaptive immunity. In this study, we analyzed the association among single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene, with clinical patterns of AIDS progression in antiretroviral treatment (ART)-naive HIV-infected patients. Methods: We conducted a retrospective study in 667 HIV-infected patients, who were classified within three groups according to their AIDS progression pattern (183 long-term non-progressors (LTNPs), 334 moderate progressors (MPs), and 150 rapid progressors (RPs)). Five VDR SNPs (rs11568820, rs4516035, rs2228570, rs1544410, and rs7975232) were genotyped using Agena Bioscience's MassARRAY platform. Results: Significant association results were found for rs2228570. Within all HIV patients, the presence of T allele at VDR rs2228570 SNP was protective against AIDS progression (ordinal outcome) under additive (adjusted odds ratio (aOR) = 0.75; p = 0.009), dominant (aOR = 0.69; p = 0.015), and codominant (aOR = 0.56; p = 0.017) inheritance models. In addition, the same allele was protective under additive and codominant inheritance models when we compared with LTNPs vs. RPs [aOR = 0.64 (p = 0.019) and aOR = 0.37 (p = 0.018), respectively] and when we compared MPs vs. RPs [aOR = 0.72 (p = 0.035) and aOR = 0.45 (p = 0.028), respectively]. Conclusions: The VDR rs2228570 T allele was related to a lower AIDS progression pattern in ART-naive HIV-infected patients. These findings expand upon the knowledge about HIV pathogenesis in untreated HIV-infected patients with different clinical outcomes.MDPI2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones8024Journal of Clinical MedicineISSN: 20770383reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p80242026-06-12T10:20:37Z |
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