Complete Resolution of Symptoms of Primary Orthostatic Tremor with Perampanel

Primary orthostatic tremor (POT) is an infrequent disorder whose physiopathology is unknown. Current medication is largely ineffective or only offers mild benefits. A 75-year-old female with refractory POT treated with 4 mg/day of perampanel achieved complete symptom resolution. Owing to adverse eff...

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Detalles Bibliográficos
Autores: Ruiz Julián, María, Orozco, Jorge Luís, Gironell, Alexandre|||0000-0003-2109-9030
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:190790
Acceso en línea:https://ddd.uab.cat/record/190790
https://dx.doi.org/urn:doi:10.7916/D8QZ3SZD
Access Level:acceso abierto
Palabra clave:Primary orthostatic tremor
Perampanel
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spelling Complete Resolution of Symptoms of Primary Orthostatic Tremor with PerampanelRuiz Julián, MaríaOrozco, Jorge LuísGironell, Alexandre|||0000-0003-2109-9030Primary orthostatic tremorPerampanelPrimary orthostatic tremor (POT) is an infrequent disorder whose physiopathology is unknown. Current medication is largely ineffective or only offers mild benefits. A 75-year-old female with refractory POT treated with 4 mg/day of perampanel achieved complete symptom resolution. Owing to adverse effects, the patient reduced intake to 2 mg/day, but even at this lower dose the benefit was maintained. We report the complete resolution of POT symptoms using low doses of perampanel, an antiepileptic drug that blocks glutamate-mediated post-synaptic excitation. Further controlled studies are necessary to confirm this finding.Universitat Autònoma de Barcelona 22018-01-0120182018-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/190790https://dx.doi.org/urn:doi:10.7916/D8QZ3SZDreponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1907902026-06-06T12:50:31Z
dc.title.none.fl_str_mv Complete Resolution of Symptoms of Primary Orthostatic Tremor with Perampanel
title Complete Resolution of Symptoms of Primary Orthostatic Tremor with Perampanel
spellingShingle Complete Resolution of Symptoms of Primary Orthostatic Tremor with Perampanel
Ruiz Julián, María
Primary orthostatic tremor
Perampanel
title_short Complete Resolution of Symptoms of Primary Orthostatic Tremor with Perampanel
title_full Complete Resolution of Symptoms of Primary Orthostatic Tremor with Perampanel
title_fullStr Complete Resolution of Symptoms of Primary Orthostatic Tremor with Perampanel
title_full_unstemmed Complete Resolution of Symptoms of Primary Orthostatic Tremor with Perampanel
title_sort Complete Resolution of Symptoms of Primary Orthostatic Tremor with Perampanel
dc.creator.none.fl_str_mv Ruiz Julián, María
Orozco, Jorge Luís
Gironell, Alexandre|||0000-0003-2109-9030
author Ruiz Julián, María
author_facet Ruiz Julián, María
Orozco, Jorge Luís
Gironell, Alexandre|||0000-0003-2109-9030
author_role author
author2 Orozco, Jorge Luís
Gironell, Alexandre|||0000-0003-2109-9030
author2_role author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Primary orthostatic tremor
Perampanel
topic Primary orthostatic tremor
Perampanel
description Primary orthostatic tremor (POT) is an infrequent disorder whose physiopathology is unknown. Current medication is largely ineffective or only offers mild benefits. A 75-year-old female with refractory POT treated with 4 mg/day of perampanel achieved complete symptom resolution. Owing to adverse effects, the patient reduced intake to 2 mg/day, but even at this lower dose the benefit was maintained. We report the complete resolution of POT symptoms using low doses of perampanel, an antiepileptic drug that blocks glutamate-mediated post-synaptic excitation. Further controlled studies are necessary to confirm this finding.
publishDate 2018
dc.date.none.fl_str_mv 2
2018-01-01
2018
2018-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
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dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/190790
https://dx.doi.org/urn:doi:10.7916/D8QZ3SZD
url https://ddd.uab.cat/record/190790
https://dx.doi.org/urn:doi:10.7916/D8QZ3SZD
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
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eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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