Systolic blood pressure and mortality in acute symptomatic pulmonary embolism

Background: The optimal cutoff for systolic blood pressure (SBP) level to define high-risk pulmonary embolism (PE) remains to be defined. Methods: To evaluate the relationship between SBP levels on admission and mortality in patients with acute symptomatic PE, the current study included 39,257 conse...

Descripción completa

Detalles Bibliográficos
Autores: Quezada, A., Jiménez, D., Bikdeli, B., Moores, L., Porres-Aguilar, M., Aramberri, M., Otero Candelera, Remedios
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/149147
Acceso en línea:https://hdl.handle.net/11441/149147
https://doi.org/10.1016/j.ijcard.2019.11.102
Access Level:acceso abierto
Palabra clave:Mortality
Pulmonary embolism
Systolic blood pressure
id ES_18f88892efe3dafeb4b5a34f1aa3dcb8
oai_identifier_str oai:idus.us.es:11441/149147
network_acronym_str ES
network_name_str España
repository_id_str
spelling Systolic blood pressure and mortality in acute symptomatic pulmonary embolismQuezada, A.Jiménez, D.Bikdeli, B.Moores, L.Porres-Aguilar, M.Aramberri, M.Otero Candelera, RemediosMortalityPulmonary embolismSystolic blood pressureBackground: The optimal cutoff for systolic blood pressure (SBP) level to define high-risk pulmonary embolism (PE) remains to be defined. Methods: To evaluate the relationship between SBP levels on admission and mortality in patients with acute symptomatic PE, the current study included 39,257 consecutive patients with acute symptomatic PE from the RIETE registry between 2001 and 2018. Primary outcomes included all-cause and PE-specific 30-day mortality. Secondary outcomes included major bleeding and recurrent venous thromboembolism (VTE). Results: There was a linear inverse relationship between admission SBP and 30-day all-cause and PE-related mortality that persisted after multivariable adjustment. Patients in the lower SBP strata had higher rates of all-cause death (reference: SBP 110-129 mmHg) (adjusted odds ratio [OR] 2.9; 95% confidence interval [CI], 2.0-4.2 for SBP <70 mmHg; and OR 1.7; 95% CI, 1.4-2.1 for SBP 70-89 mmHg). The findings for 30-day PE-related mortality were similar (adjusted OR 4.4; 95% CI, 2.7-7.2 for SBP <70 mmHg; and OR 2.6; 95% CI, 1.9-3.4 for SBP 70-89 mmHg). Patients in the higher strata of SBP had significantly lower rates of 30-day all-cause mortality compared with the same reference group (adjusted OR 0.7; 95% CI, 0.5-0.9 for SBP 170-190 mmHg; and OR 0.6; 95% CI, 0.4-0.9 for SBP >190 mmHg). Consistent findings were also observed for 30-day PE-related death. Conclusions: In patients with acute symptomatic PE, a low SBP portends an increased risk of all-cause and PE-related mortality. The highest mortality was observed in patients with SBP <70 mmHg.ElsevierMedicinaBayer Pharma AGSanofi Spain2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/149147https://doi.org/10.1016/j.ijcard.2019.11.102reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésInternational Journal of Cardiology, 302, 157-163.https://www.sciencedirect.com/science/article/pii/S0167527319319448?via%3Dihubinfo:eu-repo/semantics/openAccessoai:idus.us.es:11441/1491472026-06-17T12:51:07Z
dc.title.none.fl_str_mv Systolic blood pressure and mortality in acute symptomatic pulmonary embolism
title Systolic blood pressure and mortality in acute symptomatic pulmonary embolism
spellingShingle Systolic blood pressure and mortality in acute symptomatic pulmonary embolism
Quezada, A.
Mortality
Pulmonary embolism
Systolic blood pressure
title_short Systolic blood pressure and mortality in acute symptomatic pulmonary embolism
title_full Systolic blood pressure and mortality in acute symptomatic pulmonary embolism
title_fullStr Systolic blood pressure and mortality in acute symptomatic pulmonary embolism
title_full_unstemmed Systolic blood pressure and mortality in acute symptomatic pulmonary embolism
title_sort Systolic blood pressure and mortality in acute symptomatic pulmonary embolism
dc.creator.none.fl_str_mv Quezada, A.
Jiménez, D.
Bikdeli, B.
Moores, L.
Porres-Aguilar, M.
Aramberri, M.
Otero Candelera, Remedios
author Quezada, A.
author_facet Quezada, A.
Jiménez, D.
Bikdeli, B.
Moores, L.
Porres-Aguilar, M.
Aramberri, M.
Otero Candelera, Remedios
author_role author
author2 Jiménez, D.
Bikdeli, B.
Moores, L.
Porres-Aguilar, M.
Aramberri, M.
Otero Candelera, Remedios
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Medicina
Bayer Pharma AG
Sanofi Spain
dc.subject.none.fl_str_mv Mortality
Pulmonary embolism
Systolic blood pressure
topic Mortality
Pulmonary embolism
Systolic blood pressure
description Background: The optimal cutoff for systolic blood pressure (SBP) level to define high-risk pulmonary embolism (PE) remains to be defined. Methods: To evaluate the relationship between SBP levels on admission and mortality in patients with acute symptomatic PE, the current study included 39,257 consecutive patients with acute symptomatic PE from the RIETE registry between 2001 and 2018. Primary outcomes included all-cause and PE-specific 30-day mortality. Secondary outcomes included major bleeding and recurrent venous thromboembolism (VTE). Results: There was a linear inverse relationship between admission SBP and 30-day all-cause and PE-related mortality that persisted after multivariable adjustment. Patients in the lower SBP strata had higher rates of all-cause death (reference: SBP 110-129 mmHg) (adjusted odds ratio [OR] 2.9; 95% confidence interval [CI], 2.0-4.2 for SBP <70 mmHg; and OR 1.7; 95% CI, 1.4-2.1 for SBP 70-89 mmHg). The findings for 30-day PE-related mortality were similar (adjusted OR 4.4; 95% CI, 2.7-7.2 for SBP <70 mmHg; and OR 2.6; 95% CI, 1.9-3.4 for SBP 70-89 mmHg). Patients in the higher strata of SBP had significantly lower rates of 30-day all-cause mortality compared with the same reference group (adjusted OR 0.7; 95% CI, 0.5-0.9 for SBP 170-190 mmHg; and OR 0.6; 95% CI, 0.4-0.9 for SBP >190 mmHg). Consistent findings were also observed for 30-day PE-related death. Conclusions: In patients with acute symptomatic PE, a low SBP portends an increased risk of all-cause and PE-related mortality. The highest mortality was observed in patients with SBP <70 mmHg.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/149147
https://doi.org/10.1016/j.ijcard.2019.11.102
url https://hdl.handle.net/11441/149147
https://doi.org/10.1016/j.ijcard.2019.11.102
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International Journal of Cardiology, 302, 157-163.
https://www.sciencedirect.com/science/article/pii/S0167527319319448?via%3Dihub
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404017755422720
score 15,300719

Similares en LA Referencia