Experimental peri-implantitis. Etiology and therapy
Peri-implantitis is a chronic inflammatory disease caused by bacteria resulting in peri-implant tissue inflammation and bone loss. Several factors such as the implantabutment connection or the implant surface are known to be closely related to the maintenance of peri-implant bone levels. Different i...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/5445 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/5445 |
| Access Level: | acceso abierto |
| Palabra clave: | 616.314-089.843(043.2) Peri-implantitis Bone regeneration Re-osseointegration Bone loss Implant surface Regeneración ósea Re-oseointegración Pérdida ósea Superficie peri-implantaria Implantes dentales Periodoncia 3213.13 Ortodoncia-Estomatología |
| Sumario: | Peri-implantitis is a chronic inflammatory disease caused by bacteria resulting in peri-implant tissue inflammation and bone loss. Several factors such as the implantabutment connection or the implant surface are known to be closely related to the maintenance of peri-implant bone levels. Different implant to abutment configurations, such as platform switching have shown to facilitate bone stability by providing extra space for the peri-implant soft tissue seal. However, its influence on the initiation and progression of peri-implantitis remains unclear. Similarly, innovations in the chemical composition of the implant surface have shown a stronger bond between the implant and the surrounding bone. However, whether this covalent bonding may as well provide increased protection against bacterial challenge and hence, a lesser incidence of periimplantitis, is still unknown. With current regenerative surgical interventions, re-osseointegration of a previously contaminated implant surface has been shown to be possible, although its predictability has not been demonstrated. Growth factors such as bone morphogenetic proteins have demonstrated osteogenic activity when used in bone regenerative interventions, mainly when used in sinus lifting and lateral bone augmentation procedures. However, studies using BMP-2 aiming for re-osseointegration of periimplantitis bone defects have showed conflicting results. Objectives: The objectives of this series of investigations were: a) to evaluate the degree of bone regeneration and re-osseointegration when combining a xenogeneic bone replacement graft plus rhBMP-2 and a collagen membrane in ligature induced periimplantitis osseous defects in dogs (study 1); b) to evaluate the rate of bone loss progression during experimentally induced peri-implantitis using two different implantabutment connections in implants with identical surface topography (study 2); c) to evaluate the influence of modifying the implant surface by adding a monolayer of multiphosphonate molecules on de-novo bone formation and osseointegration (study 3); and d) to evaluate the susceptibility to bone loss of a novel multi-phosphonate implant surface treatment during experimental peri-implantitis (study 4)... |
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