Metabolomic study of lipids in serum for biomarker discovery in Alzheimer&apos

In this study, we demonstrated the potential of direct infusion mass spectrometry for the lipidomic characterization of Alzheimer's disease. Serum samples were extracted for lipids recovery, and directly analyzed using an electrospray source. Metabolomic fingerprints were subjected to multi...

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Detalles Bibliográficos
Autores: González Domínguez, Raúl, García Barrera, Tamara, Gómez Ariza, José Luis
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universidad de Huelva (UHU)
Repositorio:Arias Montano. Repositorio Institucional de la Universidad de Huelva
Idioma:inglés
OAI Identifier:oai:ariasmontano.uhu.es:10272/14510
Acceso en línea:http://hdl.handle.net/10272/14510
Access Level:acceso abierto
Palabra clave:Alzheimer’s disease
Direct infusion mass spectrometry
Lipidomics
Biomarkers
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spelling Metabolomic study of lipids in serum for biomarker discovery in Alzheimer&aposs disease using direct infusion mass spectrometryGonzález Domínguez, RaúlGarcía Barrera, TamaraGómez Ariza, José LuisAlzheimer’s diseaseDirect infusion mass spectrometryLipidomicsBiomarkersIn this study, we demonstrated the potential of direct infusion mass spectrometry for the lipidomic characterization of Alzheimer's disease. Serum samples were extracted for lipids recovery, and directly analyzed using an electrospray source. Metabolomic fingerprints were subjected to multivariate analysis in order to discriminate between groups of patients and healthy controls, and then some key-compounds were identified as possible markers of Alzheimer's disease. Major differences were found in lipids, although some low molecular weight metabolites also showed significant changes. Thus, important metabolic pathways involved in neurodegeneration could be studied on the basis of these perturbations, such as membrane breakdown (phospholipids and diacylglycerols), oxidative stress (prostaglandins, imidazole and histidine), alterations in neurotransmission systems (oleamide and putrescine) and hyperammonaemia (guanidine and arginine). Moreover, it is noteworthy that some of these potential biomarkers have not been previously described for Alzheimer's disease.Elsevier20142014-01-0120142014-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10272/14510reponame:Arias Montano. Repositorio Institucional de la Universidad de Huelvainstname:Universidad de Huelva (UHU)InglésengMinisterio de Ciencia e Innovacion [CTM2012-38720-C03-01] Not available Not availableConsejeria de Innovacion, Ciencia y Empresa (Junta de Andalucia) [P008-FQM-3554, P009-FQM-4659] Not available Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:ariasmontano.uhu.es:10272/145102026-06-02T14:58:11Z
dc.title.none.fl_str_mv Metabolomic study of lipids in serum for biomarker discovery in Alzheimer&apos
s disease using direct infusion mass spectrometry
title Metabolomic study of lipids in serum for biomarker discovery in Alzheimer&apos
spellingShingle Metabolomic study of lipids in serum for biomarker discovery in Alzheimer&apos
González Domínguez, Raúl
Alzheimer’s disease
Direct infusion mass spectrometry
Lipidomics
Biomarkers
title_short Metabolomic study of lipids in serum for biomarker discovery in Alzheimer&apos
title_full Metabolomic study of lipids in serum for biomarker discovery in Alzheimer&apos
title_fullStr Metabolomic study of lipids in serum for biomarker discovery in Alzheimer&apos
title_full_unstemmed Metabolomic study of lipids in serum for biomarker discovery in Alzheimer&apos
title_sort Metabolomic study of lipids in serum for biomarker discovery in Alzheimer&apos
dc.creator.none.fl_str_mv González Domínguez, Raúl
García Barrera, Tamara
Gómez Ariza, José Luis
author González Domínguez, Raúl
author_facet González Domínguez, Raúl
García Barrera, Tamara
Gómez Ariza, José Luis
author_role author
author2 García Barrera, Tamara
Gómez Ariza, José Luis
author2_role author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Alzheimer’s disease
Direct infusion mass spectrometry
Lipidomics
Biomarkers
topic Alzheimer’s disease
Direct infusion mass spectrometry
Lipidomics
Biomarkers
description In this study, we demonstrated the potential of direct infusion mass spectrometry for the lipidomic characterization of Alzheimer's disease. Serum samples were extracted for lipids recovery, and directly analyzed using an electrospray source. Metabolomic fingerprints were subjected to multivariate analysis in order to discriminate between groups of patients and healthy controls, and then some key-compounds were identified as possible markers of Alzheimer's disease. Major differences were found in lipids, although some low molecular weight metabolites also showed significant changes. Thus, important metabolic pathways involved in neurodegeneration could be studied on the basis of these perturbations, such as membrane breakdown (phospholipids and diacylglycerols), oxidative stress (prostaglandins, imidazole and histidine), alterations in neurotransmission systems (oleamide and putrescine) and hyperammonaemia (guanidine and arginine). Moreover, it is noteworthy that some of these potential biomarkers have not been previously described for Alzheimer's disease.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01
2014
2014-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10272/14510
url http://hdl.handle.net/10272/14510
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Ciencia e Innovacion [CTM2012-38720-C03-01] Not available Not available
Consejeria de Innovacion, Ciencia y Empresa (Junta de Andalucia) [P008-FQM-3554, P009-FQM-4659] Not available Not available
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Arias Montano. Repositorio Institucional de la Universidad de Huelva
instname:Universidad de Huelva (UHU)
instname_str Universidad de Huelva (UHU)
reponame_str Arias Montano. Repositorio Institucional de la Universidad de Huelva
collection Arias Montano. Repositorio Institucional de la Universidad de Huelva
repository.name.fl_str_mv
repository.mail.fl_str_mv
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