Telomere Length but Not Mitochondrial DNA Copy Number Is Altered in Both Young and Old COPD

Accelerated ageing is implicated in the pathogenesis of respiratory diseases as chronic obstructive pulmonary disease (COPD), but recent evidence indicates that the COPD can have roots early in life. Here we hypothesise that the accelerated ageing markers might have a role in the pathobiology of you...

Descripción completa

Detalles Bibliográficos
Autores: Casas-Recasens, Sandra, Mendoza, Nuria, Lopez-Giraldo, Alejandra, Garcia, Tamara, García-Cosío, Borja, Pascual-Guardia, Sergi, Acosta-Castro, Ady, Borras-Santos, Alicia, Gea, Joaquim, Garrabou, Gloria, Agusti, Alvar, Faner, Rosa, EARLY COPD & BIOMEPOC Projects
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/19845
Acceso en línea:https://hdl.handle.net/20.500.13003/19845
Access Level:acceso abierto
Palabra clave:telomeres
mitochondrial DNA
chronic bronchitis
emphysema
ageing
id ES_1883dbcdf8cc72dfbbc99f8cd57e1e50
oai_identifier_str oai:docusalut.com:20.500.13003/19845
network_acronym_str ES
network_name_str España
repository_id_str
spelling Telomere Length but Not Mitochondrial DNA Copy Number Is Altered in Both Young and Old COPDCasas-Recasens, SandraMendoza, NuriaLopez-Giraldo, AlejandraGarcia, TamaraGarcía-Cosío, BorjaPascual-Guardia, SergiAcosta-Castro, AdyBorras-Santos, AliciaGea, JoaquimGarrabou, GloriaAgusti, AlvarFaner, RosaEARLY COPD & BIOMEPOC Projectstelomeresmitochondrial DNAchronic bronchitisemphysemaageingAccelerated ageing is implicated in the pathogenesis of respiratory diseases as chronic obstructive pulmonary disease (COPD), but recent evidence indicates that the COPD can have roots early in life. Here we hypothesise that the accelerated ageing markers might have a role in the pathobiology of young COPD. The objective of this study was to compare two hallmarks of ageing, telomere length (TL), and mitochondrial DNA copy number (mtDNA-CN, as a surrogate marker of mitochondrial dysfunction) in young (<= 50 years) and old (>50 years) smokers, with and without COPD. Both, TL and mtDNA-CN were measured in whole blood DNA by quantitative PCR [qPCR] in: (1) young ever smokers with (n = 81) or without (n = 166) COPD; and (2) old ever smokers with (n = 159) or without (n = 29) COPD. A multivariable linear regression was used to assess the association of TL and mtDNA-CN with lung function. We observed that in the entire study population, TL and mtDNA-CN decreased with age, and the former but not the latter related to FEV1/FVC (%), FEV1 (% ref.), and DLCO (% ref.). The short telomeres were found both in the young and old patients with severe COPD (FEV1 <50% ref.). In addition, we found that TL and mtDNA-CN were significantly correlated, but their relationship was positive in younger while negative in the older patients with COPD, suggesting a mitochondrial dysfunction. We conclude that TL, but not mtDNA-CN, is associated with the lung function impairment. Both young and old patients with severe COPD have evidence of accelerated ageing (shorter TL) but differ in the direction of the correlation between TL and mtDNA-CN in relation to age.Frontiers Media Sa20212021-11-2420212021-11-24research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/19845reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/198452026-06-22T12:44:07Z
dc.title.none.fl_str_mv Telomere Length but Not Mitochondrial DNA Copy Number Is Altered in Both Young and Old COPD
title Telomere Length but Not Mitochondrial DNA Copy Number Is Altered in Both Young and Old COPD
spellingShingle Telomere Length but Not Mitochondrial DNA Copy Number Is Altered in Both Young and Old COPD
Casas-Recasens, Sandra
telomeres
mitochondrial DNA
chronic bronchitis
emphysema
ageing
title_short Telomere Length but Not Mitochondrial DNA Copy Number Is Altered in Both Young and Old COPD
title_full Telomere Length but Not Mitochondrial DNA Copy Number Is Altered in Both Young and Old COPD
title_fullStr Telomere Length but Not Mitochondrial DNA Copy Number Is Altered in Both Young and Old COPD
title_full_unstemmed Telomere Length but Not Mitochondrial DNA Copy Number Is Altered in Both Young and Old COPD
title_sort Telomere Length but Not Mitochondrial DNA Copy Number Is Altered in Both Young and Old COPD
dc.creator.none.fl_str_mv Casas-Recasens, Sandra
Mendoza, Nuria
Lopez-Giraldo, Alejandra
Garcia, Tamara
García-Cosío, Borja
Pascual-Guardia, Sergi
Acosta-Castro, Ady
Borras-Santos, Alicia
Gea, Joaquim
Garrabou, Gloria
Agusti, Alvar
Faner, Rosa
EARLY COPD & BIOMEPOC Projects
author Casas-Recasens, Sandra
author_facet Casas-Recasens, Sandra
Mendoza, Nuria
Lopez-Giraldo, Alejandra
Garcia, Tamara
García-Cosío, Borja
Pascual-Guardia, Sergi
Acosta-Castro, Ady
Borras-Santos, Alicia
Gea, Joaquim
Garrabou, Gloria
Agusti, Alvar
Faner, Rosa
EARLY COPD & BIOMEPOC Projects
author_role author
author2 Mendoza, Nuria
Lopez-Giraldo, Alejandra
Garcia, Tamara
García-Cosío, Borja
Pascual-Guardia, Sergi
Acosta-Castro, Ady
Borras-Santos, Alicia
Gea, Joaquim
Garrabou, Gloria
Agusti, Alvar
Faner, Rosa
EARLY COPD & BIOMEPOC Projects
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv telomeres
mitochondrial DNA
chronic bronchitis
emphysema
ageing
topic telomeres
mitochondrial DNA
chronic bronchitis
emphysema
ageing
description Accelerated ageing is implicated in the pathogenesis of respiratory diseases as chronic obstructive pulmonary disease (COPD), but recent evidence indicates that the COPD can have roots early in life. Here we hypothesise that the accelerated ageing markers might have a role in the pathobiology of young COPD. The objective of this study was to compare two hallmarks of ageing, telomere length (TL), and mitochondrial DNA copy number (mtDNA-CN, as a surrogate marker of mitochondrial dysfunction) in young (<= 50 years) and old (>50 years) smokers, with and without COPD. Both, TL and mtDNA-CN were measured in whole blood DNA by quantitative PCR [qPCR] in: (1) young ever smokers with (n = 81) or without (n = 166) COPD; and (2) old ever smokers with (n = 159) or without (n = 29) COPD. A multivariable linear regression was used to assess the association of TL and mtDNA-CN with lung function. We observed that in the entire study population, TL and mtDNA-CN decreased with age, and the former but not the latter related to FEV1/FVC (%), FEV1 (% ref.), and DLCO (% ref.). The short telomeres were found both in the young and old patients with severe COPD (FEV1 <50% ref.). In addition, we found that TL and mtDNA-CN were significantly correlated, but their relationship was positive in younger while negative in the older patients with COPD, suggesting a mitochondrial dysfunction. We conclude that TL, but not mtDNA-CN, is associated with the lung function impairment. Both young and old patients with severe COPD have evidence of accelerated ageing (shorter TL) but differ in the direction of the correlation between TL and mtDNA-CN in relation to age.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-11-24
2021
2021-11-24
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/19845
url https://hdl.handle.net/20.500.13003/19845
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media Sa
publisher.none.fl_str_mv Frontiers Media Sa
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869403990386540544
score 15.811543

Similares en LA Referencia