Assessing the presence of oligoclonal IgM bands as a prognostic biomarker of cognitive decline in the early stages of multiple sclerosis

Background: An association has been found between the presence of lipid-specific oligoclonal IgM bands (LS-OCMB) in cerebrospinal fluid and a more severe clinical multiple sclerosis course. Objective: To investigate lipid-specific oligoclonal IgM bands as a prognostic biomarker of cognitive impairme...

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Detalles Bibliográficos
Autores: Coll-Martinez, Clàudia, Buxó, Maria, Gómez, Immaculada, Villar, Luisa María, Álvarez-Bravo, Gary, Quintana Camps, Ester, Salavedra Pont, Judit, González del Rio, Marina, Muñoz San Martín, María, Robles Cedeño, René, Ramió i Torrentà, Lluís, Gich Fullà, Jordi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:dnet:recercat____::12c105c4279424a492732dd48d195f87
Acceso en línea:http://hdl.handle.net/10256/28884
https://hdl.handle.net/10256/28884
Access Level:acceso abierto
Palabra clave:Marcadors bioquímics
Biochemical markers
Deteriorament cognitiu lleu
Mild cognitive impairment
Esclerosi múltiple
Multiple sclerosis
Neuropsicologia
Neuropsychology
Descripción
Sumario:Background: An association has been found between the presence of lipid-specific oligoclonal IgM bands (LS-OCMB) in cerebrospinal fluid and a more severe clinical multiple sclerosis course. Objective: To investigate lipid-specific oligoclonal IgM bands as a prognostic biomarker of cognitive impairment in the early stages of multiple sclerosis. Methods: Forty-four patients underwent neuropsychological assessment at baseline and 4 years. Cognitive performance at follow-up was compared adjusting by age, education, anxiety–depression, and baseline performance. Results: LS-OCMB+ patients only performed worse for Long-Term Storage in the Selective Reminding Test (p =.018). Conclusion: There are no remarkable cognitive differences between LS-OCMB– and LS-OCMB+ patients in the early stages of MS.

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