The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis

Mortimer, Thomas; Zinna, Valentina Maria; Atalay, Müge; Laudanna, Carmelo; Deryagin, Oleg; Posas Solanes, Guillem; Smith, Jacob G.; García Lara, Elisa; Vaca Dempere, Mireia; Monteiro de Assis, Leonardo Vinícius; Heyde, Isabel; Koronowski, Kevin B.; Petrus, Paul; Greco, Carolina M.; Forrow, Stephen; Oster, Henrik; Sassone-Corsi, Paolo; Welz, Patrick Simon; Muñoz Cánoves, Pura, 1962-; Aznar Benitah, Salvador

The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis

In mammals, the circadian clock network drives daily rhythms of tissue-specific homeostasis. To dissect daily inter-tissue communication, we constructed a mouse minimal clock network comprising only two nodes: the peripheral epidermal clock and the central brain clock. By transcriptomic and function...

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Detalles Bibliográficos
Autores:	Mortimer, Thomas, Zinna, Valentina Maria, Atalay, Müge, Laudanna, Carmelo, Deryagin, Oleg, Posas Solanes, Guillem, Smith, Jacob G., García Lara, Elisa, Vaca Dempere, Mireia, Monteiro de Assis, Leonardo Vinícius, Heyde, Isabel, Koronowski, Kevin B., Petrus, Paul, Greco, Carolina M., Forrow, Stephen, Oster, Henrik, Sassone-Corsi, Paolo, Welz, Patrick Simon, Muñoz Cánoves, Pura, 1962-, Aznar Benitah, Salvador
Tipo de recurso:	artículo
Estado:	Versión aceptada para publicación
Fecha de publicación:	2024
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/212742
Acceso en línea:	https://hdl.handle.net/2445/212742
Access Level:	acceso abierto
Palabra clave:	Homeòstasi Ritmes circadiaris Homeostasis Circadian rhythms

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repository_id_str
spelling	The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasisMortimer, ThomasZinna, Valentina MariaAtalay, MügeLaudanna, CarmeloDeryagin, OlegPosas Solanes, GuillemSmith, Jacob G.García Lara, ElisaVaca Dempere, MireiaMonteiro de Assis, Leonardo ViníciusHeyde, IsabelKoronowski, Kevin B.Petrus, PaulGreco, Carolina M.Forrow, StephenOster, HenrikSassone-Corsi, PaoloWelz, Patrick SimonMuñoz Cánoves, Pura, 1962-Aznar Benitah, SalvadorHomeòstasiRitmes circadiarisHomeostasisCircadian rhythmsIn mammals, the circadian clock network drives daily rhythms of tissue-specific homeostasis. To dissect daily inter-tissue communication, we constructed a mouse minimal clock network comprising only two nodes: the peripheral epidermal clock and the central brain clock. By transcriptomic and functional characterization of this isolated connection, we identified a gatekeeping function of the peripheral tissue clock with respect to systemic inputs. The epidermal clock concurrently integrates and subverts brain signals to ensure timely execution of epidermal daily physiology. Timely cell-cycle termination in the epidermal stem cell compartment depends upon incorporation of clock-driven signals originating from the brain. In contrast, the epidermal clock corrects or outcompetes potentially disruptive feeding-related signals to ensure the optimal timing of DNA replication. Together, we present an approach for cataloging the systemic dependencies of daily temporal organization in a tissue and identify an essential gate-keeping function of peripheral circadian clocks that guarantees tissue homeostasis.Elsevier2024202520242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion16 p.application/pdfhttps://hdl.handle.net/2445/212742Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.stem.2024.04.013Cell Stem Cell, 2024, vol. 31, num. 6, p. 834-849https://doi.org/10.1016/j.stem.2024.04.013cc by-nc-nd (c) Elsevier, 2024http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2127422026-05-29T05:05:01Z
dc.title.none.fl_str_mv	The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis
title	The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis
spellingShingle	The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis Mortimer, Thomas Homeòstasi Ritmes circadiaris Homeostasis Circadian rhythms
title_short	The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis
title_full	The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis
title_fullStr	The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis
title_full_unstemmed	The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis
title_sort	The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis
dc.creator.none.fl_str_mv	Mortimer, Thomas Zinna, Valentina Maria Atalay, Müge Laudanna, Carmelo Deryagin, Oleg Posas Solanes, Guillem Smith, Jacob G. García Lara, Elisa Vaca Dempere, Mireia Monteiro de Assis, Leonardo Vinícius Heyde, Isabel Koronowski, Kevin B. Petrus, Paul Greco, Carolina M. Forrow, Stephen Oster, Henrik Sassone-Corsi, Paolo Welz, Patrick Simon Muñoz Cánoves, Pura, 1962- Aznar Benitah, Salvador
author	Mortimer, Thomas
author_facet	Mortimer, Thomas Zinna, Valentina Maria Atalay, Müge Laudanna, Carmelo Deryagin, Oleg Posas Solanes, Guillem Smith, Jacob G. García Lara, Elisa Vaca Dempere, Mireia Monteiro de Assis, Leonardo Vinícius Heyde, Isabel Koronowski, Kevin B. Petrus, Paul Greco, Carolina M. Forrow, Stephen Oster, Henrik Sassone-Corsi, Paolo Welz, Patrick Simon Muñoz Cánoves, Pura, 1962- Aznar Benitah, Salvador
author_role	author
author2	Zinna, Valentina Maria Atalay, Müge Laudanna, Carmelo Deryagin, Oleg Posas Solanes, Guillem Smith, Jacob G. García Lara, Elisa Vaca Dempere, Mireia Monteiro de Assis, Leonardo Vinícius Heyde, Isabel Koronowski, Kevin B. Petrus, Paul Greco, Carolina M. Forrow, Stephen Oster, Henrik Sassone-Corsi, Paolo Welz, Patrick Simon Muñoz Cánoves, Pura, 1962- Aznar Benitah, Salvador
author2_role	author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Homeòstasi Ritmes circadiaris Homeostasis Circadian rhythms
topic	Homeòstasi Ritmes circadiaris Homeostasis Circadian rhythms
description	In mammals, the circadian clock network drives daily rhythms of tissue-specific homeostasis. To dissect daily inter-tissue communication, we constructed a mouse minimal clock network comprising only two nodes: the peripheral epidermal clock and the central brain clock. By transcriptomic and functional characterization of this isolated connection, we identified a gatekeeping function of the peripheral tissue clock with respect to systemic inputs. The epidermal clock concurrently integrates and subverts brain signals to ensure timely execution of epidermal daily physiology. Timely cell-cycle termination in the epidermal stem cell compartment depends upon incorporation of clock-driven signals originating from the brain. In contrast, the epidermal clock corrects or outcompetes potentially disruptive feeding-related signals to ensure the optimal timing of DNA replication. Together, we present an approach for cataloging the systemic dependencies of daily temporal organization in a tissue and identify an essential gate-keeping function of peripheral circadian clocks that guarantees tissue homeostasis.
publishDate	2024
dc.date.none.fl_str_mv	2024 2024 2024 2025
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion
format	article
status_str	acceptedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/212742
url	https://hdl.handle.net/2445/212742
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Versió postprint del document publicat a: https://doi.org/10.1016/j.stem.2024.04.013 Cell Stem Cell, 2024, vol. 31, num. 6, p. 834-849 https://doi.org/10.1016/j.stem.2024.04.013
dc.rights.none.fl_str_mv	cc by-nc-nd (c) Elsevier, 2024 http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc by-nc-nd (c) Elsevier, 2024 http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	16 p. application/pdf
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,81155

The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis

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