Emerging roles for tubulin folding cofactors at the centrosome
Despite its fundamental role in centrosome biology, procentriole formation both in the canonical and in the de novo replication pathways remains poorly understood, and the molecular components that are involved in human cells are not well established. We found that one of the tubulin cofactors, TBCD...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2010 |
| País: | España |
| Institución: | Universidad de Cantabria (UC) |
| Repositorio: | UCrea Repositorio Abierto de la Universidad de Cantabria |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unican.es:10902/1146 |
| Acceso en línea: | http://hdl.handle.net/10902/1146 |
| Access Level: | acceso abierto |
| Palabra clave: | TBCs Cofactors Tubulin Folding TBCD Centrosome Centrilogenesis Ciliogenesis Abcission |
| Sumario: | Despite its fundamental role in centrosome biology, procentriole formation both in the canonical and in the de novo replication pathways remains poorly understood, and the molecular components that are involved in human cells are not well established. We found that one of the tubulin cofactors, TBCD, is localized at centrosomes and the midbody, and is required for spindle organization, cell abscission, centriole formation, and ciliogenesis. Thus, we have established a molecular link between the centriole and the midbody, demonstrating that this cofactor is also necessary for microtubule retraction during cell abscission. TBCD is the first centriolar protein identified that plays a role in the assembly of both “centriolar rosettes” during early ciliogenesis, and at the procentriole budding site by S/G2, a discovery that directly implicates tubulin cofactors in the cell division, cell migration, and cell signaling research fields. |
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