Targeting cancer stem cell OXPHOS with tailored ruthenium complexes as a new anti-cancer strategy

[Background]: Previous studies by our group have shown that oxidative phosphorylation (OXPHOS) is the main pathway by which pancreatic cancer stem cells (CSCs) meet their energetic requirements; therefore, OXPHOS represents an Achille’s heel of these highly tumorigenic cells. Unfortunately, therapie...

Descripción completa

Detalles Bibliográficos
Autores: Alcalá, Sonia, Villarino, Lara, Ruiz-Cañas, Laura, Couceiro, José R., Martínez‑Calvo, Miguel, Palencia-Campos, Adrián, Navarro, Diego, Cabezas-Sainz, Pablo, Rodríguez‑Arabaolaza, Iker, Cordero‑Barreal, Alfonso, Trilla-Fuertes, Lucía, Rubiolo, Juan A., Batres-Ramos, Sandra, Vallespinós, Mireia, González‑Páramos, Cristina, Rodríguez, Jéssica, Gámez, Ángelo, Fresno Vara, Juan Ángel, Fra Fernández, Sara, Benito Berlinches, Amparo, Moreno‑Mata, Nicolás, Torres Redondo, Ana María, Carrato, Alfredo, Hermann, Patrick C., Sánchez, Laura, Torrente, Susana, Fernández‑Moreno, Miguel Ángel, Mascareñas, José L., Sainz, Bruno Jr.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/363933
Acceso en línea:http://hdl.handle.net/10261/363933
Access Level:acceso abierto
Palabra clave:Pancreatic ductal adenocarcinoma
Cancer stem cells
Ruthenium complexes
Mitochondrial DNA
Anti-cancer agents
Oxidative phosphorylation
Patient-derived xenografts
Colon cancer
Descripción
Sumario:[Background]: Previous studies by our group have shown that oxidative phosphorylation (OXPHOS) is the main pathway by which pancreatic cancer stem cells (CSCs) meet their energetic requirements; therefore, OXPHOS represents an Achille’s heel of these highly tumorigenic cells. Unfortunately, therapies that target OXPHOS in CSCs are lacking.

Similares en LA Referencia