The acidophilic microalga Coccomyxa onubensis and atorvastatin equally improve antihyperglycemic and antihyperlipidemic protective effects on rats fed on high-fat diets

2 Tablas.-- 3 Figuras

Detalles Bibliográficos
Autores: Navarro, Francisco, Toimil, Alberto, Ramírez, Sara, Montero, Yina, Fuentes, Juan Luis, Perona, Javier S., Castaño, Miguel Ángel, Pasaro, Rosario, Vega, José M., Vílchez, Carlos
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/221620
Acceso en línea:http://hdl.handle.net/10261/221620
Access Level:acceso abierto
Palabra clave:Atorvastatin
Coccomyxa onubensis
Chlorophyceae
Polyunsaturated fatty acids
Hypercholesterolemia
Rat metabolic syndrome
Hyperglycemia
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spelling The acidophilic microalga Coccomyxa onubensis and atorvastatin equally improve antihyperglycemic and antihyperlipidemic protective effects on rats fed on high-fat dietsNavarro, FranciscoToimil, AlbertoRamírez, SaraMontero, YinaFuentes, Juan LuisPerona, Javier S.Castaño, Miguel ÁngelPasaro, RosarioVega, José M.Vílchez, CarlosAtorvastatinCoccomyxa onubensisChlorophyceaePolyunsaturated fatty acidsHypercholesterolemiaRat metabolic syndromeHyperglycemia2 Tablas.-- 3 FigurasBiomass of the acidophilic green alga Coccomyxa onubensis may be used as a food source for animals without collateral toxic effects, as diet supplemented the microalga has significant hypoglycemic and hypocholesterolemic effects on healthy animals. Rats were fed for 108 days with a high-fat diet, and at the end of the experiment, they were overweight and had significantly increased serum levels of glucose (2.0-fold), total cholesterol (1.6-fold), and low-density lipoprotein (LDL)-cholesterol (7.7-fold). The supplement of C. onubensis powder (6.25% w/w dry weight) in the high-fat diet significantly protected the rats against cardiovascular risks by reducing the serum levels of glucose (38.47%), total cholesterol (22.65%), and LDL-cholesterol (26.70%). The protective effects of the microalga were comparable with that of 10 mg/kg body weight per day of atorvastatin. The high-fat diet decreased both ω–3 eicosapentaenoic and docosahexaenoic acids in the brain tissue of rats; however, C. onubensis powder could not restrict these changes. Simultaneously, the high-fat diet increased the levels of both palmitic and arachidonic (ω–6) acids in the telencephalon tissue of rats; this was prevented when microalga biomass was used in the diet of rats.This study is funded by the University of Huelva and Andalusian Government (research project BIO–214).Peer reviewedSpringer NatureUniversidad de HuelvaJunta de AndalucíaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/221620reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1007/s10811-020-02280-4Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2216202026-05-22T06:33:51Z
dc.title.none.fl_str_mv The acidophilic microalga Coccomyxa onubensis and atorvastatin equally improve antihyperglycemic and antihyperlipidemic protective effects on rats fed on high-fat diets
title The acidophilic microalga Coccomyxa onubensis and atorvastatin equally improve antihyperglycemic and antihyperlipidemic protective effects on rats fed on high-fat diets
spellingShingle The acidophilic microalga Coccomyxa onubensis and atorvastatin equally improve antihyperglycemic and antihyperlipidemic protective effects on rats fed on high-fat diets
Navarro, Francisco
Atorvastatin
Coccomyxa onubensis
Chlorophyceae
Polyunsaturated fatty acids
Hypercholesterolemia
Rat metabolic syndrome
Hyperglycemia
title_short The acidophilic microalga Coccomyxa onubensis and atorvastatin equally improve antihyperglycemic and antihyperlipidemic protective effects on rats fed on high-fat diets
title_full The acidophilic microalga Coccomyxa onubensis and atorvastatin equally improve antihyperglycemic and antihyperlipidemic protective effects on rats fed on high-fat diets
title_fullStr The acidophilic microalga Coccomyxa onubensis and atorvastatin equally improve antihyperglycemic and antihyperlipidemic protective effects on rats fed on high-fat diets
title_full_unstemmed The acidophilic microalga Coccomyxa onubensis and atorvastatin equally improve antihyperglycemic and antihyperlipidemic protective effects on rats fed on high-fat diets
title_sort The acidophilic microalga Coccomyxa onubensis and atorvastatin equally improve antihyperglycemic and antihyperlipidemic protective effects on rats fed on high-fat diets
dc.creator.none.fl_str_mv Navarro, Francisco
Toimil, Alberto
Ramírez, Sara
Montero, Yina
Fuentes, Juan Luis
Perona, Javier S.
Castaño, Miguel Ángel
Pasaro, Rosario
Vega, José M.
Vílchez, Carlos
author Navarro, Francisco
author_facet Navarro, Francisco
Toimil, Alberto
Ramírez, Sara
Montero, Yina
Fuentes, Juan Luis
Perona, Javier S.
Castaño, Miguel Ángel
Pasaro, Rosario
Vega, José M.
Vílchez, Carlos
author_role author
author2 Toimil, Alberto
Ramírez, Sara
Montero, Yina
Fuentes, Juan Luis
Perona, Javier S.
Castaño, Miguel Ángel
Pasaro, Rosario
Vega, José M.
Vílchez, Carlos
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Huelva
Junta de Andalucía
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Atorvastatin
Coccomyxa onubensis
Chlorophyceae
Polyunsaturated fatty acids
Hypercholesterolemia
Rat metabolic syndrome
Hyperglycemia
topic Atorvastatin
Coccomyxa onubensis
Chlorophyceae
Polyunsaturated fatty acids
Hypercholesterolemia
Rat metabolic syndrome
Hyperglycemia
description 2 Tablas.-- 3 Figuras
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/221620
url http://hdl.handle.net/10261/221620
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1007/s10811-020-02280-4
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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