Effectiveness of the 2010-2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: A case-case comparison, case-control study

Introduction: We estimated influenza vaccine effectiveness (IVE) to prevent laboratory-confirmed influenza-related hospitalizations in patients 18 years old or older during the 2010-2011 influenza season. Methods: We conducted a prospective case-control study in five hospitals, in Valencia, Spain. S...

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Autores: Puig-Barberà J, Díez-Domingo J, Arnedo-Pena A, Ruiz-García M, Pérez-Vilar S, Micó-Esparza JL, Belenguer-Varea A, Carratalá-Munuera C, GIL, V., Schwarz-Chavarri H
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:España
Recursos:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p3427
Acesso em linha:https://fisabio.portalinvestigacion.com/publicaciones/3427
Access Level:acceso abierto
Palavra-chave:Case-control studies
Hospitalizations
Humans
Influenza vaccines
Risk factors
Vaccines, Inactivated
Reverse transcriptase polymerase chain reaction
Influenza, Human/epidemiology
Respiratory syncytial virus infections/epidemiology
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spelling Effectiveness of the 2010-2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: A case-case comparison, case-control studyPuig-Barberà JDíez-Domingo JArnedo-Pena ARuiz-García MPérez-Vilar SMicó-Esparza JLBelenguer-Varea ACarratalá-Munuera CGIL, V.Schwarz-Chavarri HCase-control studiesHospitalizationsHumansInfluenza vaccinesRisk factorsVaccines, InactivatedReverse transcriptase polymerase chain reactionInfluenza, Human/epidemiologyRespiratory syncytial virus infections/epidemiologyIntroduction: We estimated influenza vaccine effectiveness (IVE) to prevent laboratory-confirmed influenza-related hospitalizations in patients 18 years old or older during the 2010-2011 influenza season. Methods: We conducted a prospective case-control study in five hospitals, in Valencia, Spain. Study subjects were consecutive emergency hospitalizations for predefined conditions associated with an influenza-like illness episode <8 days before admission. Patients were considered immunized if vaccinated >= 14 days before influenza-like illness onset. Cases were those with a real time reverse transcriptase polymerase chain reaction (RT-PCR) positive for influenza and controls were RT-PCR positive for other respiratory viruses. Adjusted WE was estimated as 100 x (1 - adjusted odds ratio). To account for indication bias we computed adjusted IVE for respiratory syncytial virus related hospitalizations. Results: Of 826 eligible hospitalized patients, 102 (12%) were influenza positive and considered cases, and 116(14%) were positive for other respiratory viruses and considered controls. Adjusted IVE was 54% (95% confidence interval, 11-76%). By subgroup, adjusted WE was 53% (4-77%) for those with high-risk conditions, 59% (16-79%) for those >= 60 years of age, and, 54% (4-79%) for those >= 60 years of age with high-risk conditions. No influenza vaccine effect was observed against respiratory syncytial virus related hospitalization. Conclusion: Influenza vaccination was associated with a significant reduction on the risk of confirmed influenza hospitalization, irrespective of age and high-risk conditions. (C) 2012 Elsevier Ltd. All rightsElsevier BV2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/3427VaccineISSN: 13588745ISSNe: 0264410Xreponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p34272026-06-11T12:45:17Z
dc.title.none.fl_str_mv Effectiveness of the 2010-2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: A case-case comparison, case-control study
title Effectiveness of the 2010-2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: A case-case comparison, case-control study
spellingShingle Effectiveness of the 2010-2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: A case-case comparison, case-control study
Puig-Barberà J
Case-control studies
Hospitalizations
Humans
Influenza vaccines
Risk factors
Vaccines, Inactivated
Reverse transcriptase polymerase chain reaction
Influenza, Human/epidemiology
Respiratory syncytial virus infections/epidemiology
title_short Effectiveness of the 2010-2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: A case-case comparison, case-control study
title_full Effectiveness of the 2010-2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: A case-case comparison, case-control study
title_fullStr Effectiveness of the 2010-2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: A case-case comparison, case-control study
title_full_unstemmed Effectiveness of the 2010-2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: A case-case comparison, case-control study
title_sort Effectiveness of the 2010-2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: A case-case comparison, case-control study
dc.creator.none.fl_str_mv Puig-Barberà J
Díez-Domingo J
Arnedo-Pena A
Ruiz-García M
Pérez-Vilar S
Micó-Esparza JL
Belenguer-Varea A
Carratalá-Munuera C
GIL, V.
Schwarz-Chavarri H
author Puig-Barberà J
author_facet Puig-Barberà J
Díez-Domingo J
Arnedo-Pena A
Ruiz-García M
Pérez-Vilar S
Micó-Esparza JL
Belenguer-Varea A
Carratalá-Munuera C
GIL, V.
Schwarz-Chavarri H
author_role author
author2 Díez-Domingo J
Arnedo-Pena A
Ruiz-García M
Pérez-Vilar S
Micó-Esparza JL
Belenguer-Varea A
Carratalá-Munuera C
GIL, V.
Schwarz-Chavarri H
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Case-control studies
Hospitalizations
Humans
Influenza vaccines
Risk factors
Vaccines, Inactivated
Reverse transcriptase polymerase chain reaction
Influenza, Human/epidemiology
Respiratory syncytial virus infections/epidemiology
topic Case-control studies
Hospitalizations
Humans
Influenza vaccines
Risk factors
Vaccines, Inactivated
Reverse transcriptase polymerase chain reaction
Influenza, Human/epidemiology
Respiratory syncytial virus infections/epidemiology
description Introduction: We estimated influenza vaccine effectiveness (IVE) to prevent laboratory-confirmed influenza-related hospitalizations in patients 18 years old or older during the 2010-2011 influenza season. Methods: We conducted a prospective case-control study in five hospitals, in Valencia, Spain. Study subjects were consecutive emergency hospitalizations for predefined conditions associated with an influenza-like illness episode <8 days before admission. Patients were considered immunized if vaccinated >= 14 days before influenza-like illness onset. Cases were those with a real time reverse transcriptase polymerase chain reaction (RT-PCR) positive for influenza and controls were RT-PCR positive for other respiratory viruses. Adjusted WE was estimated as 100 x (1 - adjusted odds ratio). To account for indication bias we computed adjusted IVE for respiratory syncytial virus related hospitalizations. Results: Of 826 eligible hospitalized patients, 102 (12%) were influenza positive and considered cases, and 116(14%) were positive for other respiratory viruses and considered controls. Adjusted IVE was 54% (95% confidence interval, 11-76%). By subgroup, adjusted WE was 53% (4-77%) for those with high-risk conditions, 59% (16-79%) for those >= 60 years of age, and, 54% (4-79%) for those >= 60 years of age with high-risk conditions. No influenza vaccine effect was observed against respiratory syncytial virus related hospitalization. Conclusion: Influenza vaccination was associated with a significant reduction on the risk of confirmed influenza hospitalization, irrespective of age and high-risk conditions. (C) 2012 Elsevier Ltd. All rights
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/3427
url https://fisabio.portalinvestigacion.com/publicaciones/3427
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv Vaccine
ISSN: 13588745
ISSNe: 0264410X
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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