Multiplexed Electrochemical Immunosensors for Clinical Biomarkers

Management and prognosis of disease requires the accurate determination of specific biomarkers indicative of normal or disease-related biological processes or responses to therapy. Moreover since multiple determinations of biomarkers have demonstrated to provide more accurate information than indivi...

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Detalles Bibliográficos
Autores: Yáñez-Sedeño Orive, Paloma, Campuzano Ruiz, Susana, Pingarrón Carrazón, José Manuel
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/19204
Acceso en línea:https://hdl.handle.net/20.500.14352/19204
Access Level:acceso abierto
Palabra clave:multiplexed electrochemical immunosensors
biomarkers
cancer
cardiovascular
microfluidic
paper electrodes
Química analítica (Química)
2301 Química Analítica
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spelling Multiplexed Electrochemical Immunosensors for Clinical BiomarkersYáñez-Sedeño Orive, PalomaCampuzano Ruiz, SusanaPingarrón Carrazón, José Manuelmultiplexed electrochemical immunosensorsbiomarkerscancercardiovascularmicrofluidicpaper electrodesQuímica analítica (Química)2301 Química AnalíticaManagement and prognosis of disease requires the accurate determination of specific biomarkers indicative of normal or disease-related biological processes or responses to therapy. Moreover since multiple determinations of biomarkers have demonstrated to provide more accurate information than individual determinations to assist the clinician in prognosis and diagnosis, the detection of several clinical biomarkers by using the same analytical device hold enormous potential for early detection and personalized therapy and will simplify the diagnosis providing more information in less time. In this field, electrochemical immunosensors have demonstrated to offer interesting alternatives against conventional strategies due to their simplicity, fast response, low cost, high sensitivity and compatibility with multiplexed determination, microfabrication technology and decentralized determinations, features which made them very attractive for integration in point-of-care (POC) devices. Therefore, in this review, the relevance and current challenges of multiplexed determination of clinical biomarkers are briefly introduced, and an overview of the electrochemical immunosensing platforms developed so far for this purpose is given in order to demonstrate the great potential of these methodologies. After highlighting the main features of the selected examples, the unsolved challenges and future directions in this field are also briefly discussed.MDPIUniversidad Complutense de Madrid20172017-04-2720172017-04-27journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/19204reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/192042026-06-02T12:44:21Z
dc.title.none.fl_str_mv Multiplexed Electrochemical Immunosensors for Clinical Biomarkers
title Multiplexed Electrochemical Immunosensors for Clinical Biomarkers
spellingShingle Multiplexed Electrochemical Immunosensors for Clinical Biomarkers
Yáñez-Sedeño Orive, Paloma
multiplexed electrochemical immunosensors
biomarkers
cancer
cardiovascular
microfluidic
paper electrodes
Química analítica (Química)
2301 Química Analítica
title_short Multiplexed Electrochemical Immunosensors for Clinical Biomarkers
title_full Multiplexed Electrochemical Immunosensors for Clinical Biomarkers
title_fullStr Multiplexed Electrochemical Immunosensors for Clinical Biomarkers
title_full_unstemmed Multiplexed Electrochemical Immunosensors for Clinical Biomarkers
title_sort Multiplexed Electrochemical Immunosensors for Clinical Biomarkers
dc.creator.none.fl_str_mv Yáñez-Sedeño Orive, Paloma
Campuzano Ruiz, Susana
Pingarrón Carrazón, José Manuel
author Yáñez-Sedeño Orive, Paloma
author_facet Yáñez-Sedeño Orive, Paloma
Campuzano Ruiz, Susana
Pingarrón Carrazón, José Manuel
author_role author
author2 Campuzano Ruiz, Susana
Pingarrón Carrazón, José Manuel
author2_role author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv multiplexed electrochemical immunosensors
biomarkers
cancer
cardiovascular
microfluidic
paper electrodes
Química analítica (Química)
2301 Química Analítica
topic multiplexed electrochemical immunosensors
biomarkers
cancer
cardiovascular
microfluidic
paper electrodes
Química analítica (Química)
2301 Química Analítica
description Management and prognosis of disease requires the accurate determination of specific biomarkers indicative of normal or disease-related biological processes or responses to therapy. Moreover since multiple determinations of biomarkers have demonstrated to provide more accurate information than individual determinations to assist the clinician in prognosis and diagnosis, the detection of several clinical biomarkers by using the same analytical device hold enormous potential for early detection and personalized therapy and will simplify the diagnosis providing more information in less time. In this field, electrochemical immunosensors have demonstrated to offer interesting alternatives against conventional strategies due to their simplicity, fast response, low cost, high sensitivity and compatibility with multiplexed determination, microfabrication technology and decentralized determinations, features which made them very attractive for integration in point-of-care (POC) devices. Therefore, in this review, the relevance and current challenges of multiplexed determination of clinical biomarkers are briefly introduced, and an overview of the electrochemical immunosensing platforms developed so far for this purpose is given in order to demonstrate the great potential of these methodologies. After highlighting the main features of the selected examples, the unsolved challenges and future directions in this field are also briefly discussed.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-04-27
2017
2017-04-27
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/19204
url https://hdl.handle.net/20.500.14352/19204
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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