NRN1 gene as a potential marker of early-onset schizophrenia: evidence from genetic and neuroimaging approaches

Included in the neurotrophins family, the Neuritin 1 gene (NRN1) has emerged as an attractive candidate gene for schizophrenia (SZ) since it has been associated with the risk for the disorder and general cognitive performance. In this work, we aimed to further investigate the association of NRN1 wit...

Descripción completa

Detalles Bibliográficos
Autores: Almodóvar-Payá, Carmen, Guardiola-Ripoll, María, Giralt-López, María, Gallego, Carme, Salgado-Pineda, Pilar, Miret, Salvador, Salvador, Raymond, Muñoz, María J., Lázaro, Luisa, Guerrero-Pedraza, Amalia, Carrión, María I., Cuesta, Manuel J., Maristany, Teresa, Fañanás, Lourdes, Callado, Luis F., Arias, Bárbara, Pomarol-Clotet, Edith, Fatjó-Vilas, Mar
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/285501
Acceso en línea:http://hdl.handle.net/10261/285501
Access Level:acceso abierto
Palabra clave:Schizophrenia-spectrum disorders
NRN1
Age at onset
Working memory
Functional magnetic resonance imaging (fMRI)
id ES_17d495c21ae16bbb514a9082d3ce17f5
oai_identifier_str oai:digital.csic.es:10261/285501
network_acronym_str ES
network_name_str España
repository_id_str
spelling NRN1 gene as a potential marker of early-onset schizophrenia: evidence from genetic and neuroimaging approachesAlmodóvar-Payá, CarmenGuardiola-Ripoll, MaríaGiralt-López, MaríaGallego, CarmeSalgado-Pineda, PilarMiret, SalvadorSalvador, RaymondMuñoz, María J.Lázaro, LuisaGuerrero-Pedraza, AmaliaCarrión, María I.Cuesta, Manuel J.Maristany, TeresaFañanás, LourdesCallado, Luis F.Arias, BárbaraPomarol-Clotet, EdithFatjó-Vilas, MarSchizophrenia-spectrum disordersNRN1Age at onsetWorking memoryFunctional magnetic resonance imaging (fMRI)Included in the neurotrophins family, the Neuritin 1 gene (NRN1) has emerged as an attractive candidate gene for schizophrenia (SZ) since it has been associated with the risk for the disorder and general cognitive performance. In this work, we aimed to further investigate the association of NRN1 with SZ by exploring its role on age at onset and its brain activity correlates. First, we developed two genetic association analyses using a family-based sample (80 early-onset (EO) trios (offspring onset ≤ 18 years) and 71 adult-onset (AO) trios) and an independent case–control sample (120 healthy subjects (HS), 87 EO and 138 AO patients). Second, we explored the effect of NRN1 on brain activity during a working memory task (N-back task; 39 HS, 39 EO and 39 AO; matched by age, sex and estimated IQ). Different haplotypes encompassing the same three Single Nucleotide Polymorphisms(SNPs, rs3763180–rs10484320–rs4960155) were associated with EO in the two samples (GCT, TCC and GTT). Besides, the GTT haplotype was associated with worse N-back task performance in EO and was linked to an inefficient dorsolateral prefrontal cortex activity in subjects with EO compared to HS. Our results show convergent evidence on the NRN1 association with EO both from genetic and neuroimaging approaches, highlighting the role of neurotrophins in the pathophysiology of SZ.This study received funding provided by: (i) Fundación Alicia Koplowitz; (ii) Acadèmia de les Ciències Mèdiques i de la Salut de Catalunya i de Balears (predoctoral contract to C.A.-P.); (iii) the Instituto de Salud Carlos III through a PFIS predoctoral contract to M.G.-R. (FI19/0352) and a Miguel Servet contract to M.F.-V. (CP20/00072), co-funded by European Regional Development Fund (ERDF)/European Social Fund “Investing in your future”; (iv) the Comissionat per a Universitats i Recerca del DIUE of the Generalitat de Catalunya (Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR), 2017SGR1271 and 2017SGR1577).Multidisciplinary Digital Publishing InstituteFundación Alicia KoplowitzInstituto de Salud Carlos IIIEuropean CommissionGeneralitat de CatalunyaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/285501reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3390/ijms23137456Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2855012026-05-22T06:33:51Z
dc.title.none.fl_str_mv NRN1 gene as a potential marker of early-onset schizophrenia: evidence from genetic and neuroimaging approaches
title NRN1 gene as a potential marker of early-onset schizophrenia: evidence from genetic and neuroimaging approaches
spellingShingle NRN1 gene as a potential marker of early-onset schizophrenia: evidence from genetic and neuroimaging approaches
Almodóvar-Payá, Carmen
Schizophrenia-spectrum disorders
NRN1
Age at onset
Working memory
Functional magnetic resonance imaging (fMRI)
title_short NRN1 gene as a potential marker of early-onset schizophrenia: evidence from genetic and neuroimaging approaches
title_full NRN1 gene as a potential marker of early-onset schizophrenia: evidence from genetic and neuroimaging approaches
title_fullStr NRN1 gene as a potential marker of early-onset schizophrenia: evidence from genetic and neuroimaging approaches
title_full_unstemmed NRN1 gene as a potential marker of early-onset schizophrenia: evidence from genetic and neuroimaging approaches
title_sort NRN1 gene as a potential marker of early-onset schizophrenia: evidence from genetic and neuroimaging approaches
dc.creator.none.fl_str_mv Almodóvar-Payá, Carmen
Guardiola-Ripoll, María
Giralt-López, María
Gallego, Carme
Salgado-Pineda, Pilar
Miret, Salvador
Salvador, Raymond
Muñoz, María J.
Lázaro, Luisa
Guerrero-Pedraza, Amalia
Carrión, María I.
Cuesta, Manuel J.
Maristany, Teresa
Fañanás, Lourdes
Callado, Luis F.
Arias, Bárbara
Pomarol-Clotet, Edith
Fatjó-Vilas, Mar
author Almodóvar-Payá, Carmen
author_facet Almodóvar-Payá, Carmen
Guardiola-Ripoll, María
Giralt-López, María
Gallego, Carme
Salgado-Pineda, Pilar
Miret, Salvador
Salvador, Raymond
Muñoz, María J.
Lázaro, Luisa
Guerrero-Pedraza, Amalia
Carrión, María I.
Cuesta, Manuel J.
Maristany, Teresa
Fañanás, Lourdes
Callado, Luis F.
Arias, Bárbara
Pomarol-Clotet, Edith
Fatjó-Vilas, Mar
author_role author
author2 Guardiola-Ripoll, María
Giralt-López, María
Gallego, Carme
Salgado-Pineda, Pilar
Miret, Salvador
Salvador, Raymond
Muñoz, María J.
Lázaro, Luisa
Guerrero-Pedraza, Amalia
Carrión, María I.
Cuesta, Manuel J.
Maristany, Teresa
Fañanás, Lourdes
Callado, Luis F.
Arias, Bárbara
Pomarol-Clotet, Edith
Fatjó-Vilas, Mar
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Fundación Alicia Koplowitz
Instituto de Salud Carlos III
European Commission
Generalitat de Catalunya
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Schizophrenia-spectrum disorders
NRN1
Age at onset
Working memory
Functional magnetic resonance imaging (fMRI)
topic Schizophrenia-spectrum disorders
NRN1
Age at onset
Working memory
Functional magnetic resonance imaging (fMRI)
description Included in the neurotrophins family, the Neuritin 1 gene (NRN1) has emerged as an attractive candidate gene for schizophrenia (SZ) since it has been associated with the risk for the disorder and general cognitive performance. In this work, we aimed to further investigate the association of NRN1 with SZ by exploring its role on age at onset and its brain activity correlates. First, we developed two genetic association analyses using a family-based sample (80 early-onset (EO) trios (offspring onset ≤ 18 years) and 71 adult-onset (AO) trios) and an independent case–control sample (120 healthy subjects (HS), 87 EO and 138 AO patients). Second, we explored the effect of NRN1 on brain activity during a working memory task (N-back task; 39 HS, 39 EO and 39 AO; matched by age, sex and estimated IQ). Different haplotypes encompassing the same three Single Nucleotide Polymorphisms(SNPs, rs3763180–rs10484320–rs4960155) were associated with EO in the two samples (GCT, TCC and GTT). Besides, the GTT haplotype was associated with worse N-back task performance in EO and was linked to an inefficient dorsolateral prefrontal cortex activity in subjects with EO compared to HS. Our results show convergent evidence on the NRN1 association with EO both from genetic and neuroimaging approaches, highlighting the role of neurotrophins in the pathophysiology of SZ.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/285501
url http://hdl.handle.net/10261/285501
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.3390/ijms23137456
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869403946128244736
score 15.812429

Similares en LA Referencia