Number of CAG repeats and mortality in middle aged and older men

Design: The androgen receptor (AR) mediates peripheral effects of testosterone. Previous data suggests an association between the number of CAG repeats in exon-1 of the AR gene and AR transcriptional activity. The aim of this analysis was to determine the association between the number of AR CAG rep...

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Autores: Heald, A., Cook, M.J., Antonio, L., Tournoy, J., Ghaffari, P., Mannan, F., Fachim, H., Vanderschueren, D., Laing, I., Hackett, G., Casanueva Freijo, Felipe, Huhtaniemi, I.T., Maggi, M., Rastrelli, G., Slowikowska-Hilczer, J., Wu, F., O'Neill, T.W.
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/21794
Acceso en línea:https://portalcientifico.sergas.gal//documentos/651014aa0058624993e2cdf9
http://hdl.handle.net/20.500.11940/21794
Access Level:acceso abierto
Palabra clave:Humans
Middle Aged
Male
Aged
Receptors, Androgen
Trinucleotide Repeats
Aging
Testosterone
AS Santiago
IDIS
id ES_17cc2e1ccc6dacfb2be4090cf9b5ea34
oai_identifier_str oai:runa.sergas.gal:20.500.11940/21794
network_acronym_str ES
network_name_str España
repository_id_str
spelling Number of CAG repeats and mortality in middle aged and older menHeald, A.Cook, M.J.Antonio, L.Tournoy, J.Ghaffari, P.Mannan, F.Fachim, H.Vanderschueren, D.Laing, I.Hackett, G.Casanueva Freijo, FelipeHuhtaniemi, I.T.Maggi, M.Rastrelli, G.Slowikowska-Hilczer, J.Wu, F.O'Neill, T.W.HumansMiddle AgedMaleAgedReceptors, AndrogenTrinucleotide RepeatsAgingTestosteroneAS SantiagoIDISDesign: The androgen receptor (AR) mediates peripheral effects of testosterone. Previous data suggests an association between the number of CAG repeats in exon-1 of the AR gene and AR transcriptional activity. The aim of this analysis was to determine the association between the number of AR CAG repeats and all-cause mortality in men and the influence of testosterone level on the association. Patients and Measurements: Follow-up data to 27 January 2018 were available for men aged 40-79 years recruited across six countries of the European Male Aging Study between 2003 and 2005. Cox proportional hazards modelling was used to determine the association between CAG repeat number/mortality. Results were expressed as hazard ratios (HR)/95% confidence intervals (CI). Results: One thousand nine hundred and seventy-seven men were followed up. Mean baseline age was 60 ± 11.1 years. Mean duration of follow-up was 12.2 years. At follow up 25.1% of men had died. CAG repeat length ranged from 6 to 39, with the highest proportion of CAG repeat number at 21 repeats (16.4%). In a multivariable model, compared to men with 22-23 AR CAG repeats: for men with <22 and >23 AR CAG HR, 95% CI for mortality were, <22 CAG repeats 1.17 (0.93-1.49) and >23 CAG repeats 1.14 (0.88-1.47). In a post-hoc analysis, the association was significant for men in the lowest tertile of baseline testosterone (<14.2 nmol/L) with >23 CAG repeats: in the adjusted model for <22 and >23 CAG repeats, respectively, 1.49 (0.97-2.27) and 1.68 (1.06-2.67) versus 22-23 repeats. Conclusions: Our European-wide cohort data overall found no association of androgen receptor CAG repeat number and mortality in men. However, post hoc analysis suggested that an association might be present in men with lower baseline testosterone concentrations, which merits further investigation.2023info:eu-repo/semantics/articlehttps://portalcientifico.sergas.gal//documentos/651014aa0058624993e2cdf9http://hdl.handle.net/20.500.11940/21794reponame:RUNA. Repositorio da Consellería de Sanidade e Sergasinstname:Servizo Galego de Saúde (SERGAS)Ingléshttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:runa.sergas.gal:20.500.11940/217942026-06-12T08:40:47Z
dc.title.none.fl_str_mv Number of CAG repeats and mortality in middle aged and older men
title Number of CAG repeats and mortality in middle aged and older men
spellingShingle Number of CAG repeats and mortality in middle aged and older men
Heald, A.
Humans
Middle Aged
Male
Aged
Receptors, Androgen
Trinucleotide Repeats
Aging
Testosterone
AS Santiago
IDIS
title_short Number of CAG repeats and mortality in middle aged and older men
title_full Number of CAG repeats and mortality in middle aged and older men
title_fullStr Number of CAG repeats and mortality in middle aged and older men
title_full_unstemmed Number of CAG repeats and mortality in middle aged and older men
title_sort Number of CAG repeats and mortality in middle aged and older men
dc.creator.none.fl_str_mv Heald, A.
Cook, M.J.
Antonio, L.
Tournoy, J.
Ghaffari, P.
Mannan, F.
Fachim, H.
Vanderschueren, D.
Laing, I.
Hackett, G.
Casanueva Freijo, Felipe
Huhtaniemi, I.T.
Maggi, M.
Rastrelli, G.
Slowikowska-Hilczer, J.
Wu, F.
O'Neill, T.W.
author Heald, A.
author_facet Heald, A.
Cook, M.J.
Antonio, L.
Tournoy, J.
Ghaffari, P.
Mannan, F.
Fachim, H.
Vanderschueren, D.
Laing, I.
Hackett, G.
Casanueva Freijo, Felipe
Huhtaniemi, I.T.
Maggi, M.
Rastrelli, G.
Slowikowska-Hilczer, J.
Wu, F.
O'Neill, T.W.
author_role author
author2 Cook, M.J.
Antonio, L.
Tournoy, J.
Ghaffari, P.
Mannan, F.
Fachim, H.
Vanderschueren, D.
Laing, I.
Hackett, G.
Casanueva Freijo, Felipe
Huhtaniemi, I.T.
Maggi, M.
Rastrelli, G.
Slowikowska-Hilczer, J.
Wu, F.
O'Neill, T.W.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Humans
Middle Aged
Male
Aged
Receptors, Androgen
Trinucleotide Repeats
Aging
Testosterone
AS Santiago
IDIS
topic Humans
Middle Aged
Male
Aged
Receptors, Androgen
Trinucleotide Repeats
Aging
Testosterone
AS Santiago
IDIS
description Design: The androgen receptor (AR) mediates peripheral effects of testosterone. Previous data suggests an association between the number of CAG repeats in exon-1 of the AR gene and AR transcriptional activity. The aim of this analysis was to determine the association between the number of AR CAG repeats and all-cause mortality in men and the influence of testosterone level on the association. Patients and Measurements: Follow-up data to 27 January 2018 were available for men aged 40-79 years recruited across six countries of the European Male Aging Study between 2003 and 2005. Cox proportional hazards modelling was used to determine the association between CAG repeat number/mortality. Results were expressed as hazard ratios (HR)/95% confidence intervals (CI). Results: One thousand nine hundred and seventy-seven men were followed up. Mean baseline age was 60 ± 11.1 years. Mean duration of follow-up was 12.2 years. At follow up 25.1% of men had died. CAG repeat length ranged from 6 to 39, with the highest proportion of CAG repeat number at 21 repeats (16.4%). In a multivariable model, compared to men with 22-23 AR CAG repeats: for men with <22 and >23 AR CAG HR, 95% CI for mortality were, <22 CAG repeats 1.17 (0.93-1.49) and >23 CAG repeats 1.14 (0.88-1.47). In a post-hoc analysis, the association was significant for men in the lowest tertile of baseline testosterone (<14.2 nmol/L) with >23 CAG repeats: in the adjusted model for <22 and >23 CAG repeats, respectively, 1.49 (0.97-2.27) and 1.68 (1.06-2.67) versus 22-23 repeats. Conclusions: Our European-wide cohort data overall found no association of androgen receptor CAG repeat number and mortality in men. However, post hoc analysis suggested that an association might be present in men with lower baseline testosterone concentrations, which merits further investigation.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://portalcientifico.sergas.gal//documentos/651014aa0058624993e2cdf9
http://hdl.handle.net/20.500.11940/21794
url https://portalcientifico.sergas.gal//documentos/651014aa0058624993e2cdf9
http://hdl.handle.net/20.500.11940/21794
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:RUNA. Repositorio da Consellería de Sanidade e Sergas
instname:Servizo Galego de Saúde (SERGAS)
instname_str Servizo Galego de Saúde (SERGAS)
reponame_str RUNA. Repositorio da Consellería de Sanidade e Sergas
collection RUNA. Repositorio da Consellería de Sanidade e Sergas
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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