Prognosis of Paradoxical Low-Flow Low-Gradient Aortic Stenosis: A Severe, Non-critical Form, With Surgical Treatment Benefits

Aortic stenosis; Echocardiography; Heart valve disease

Detalles Bibliográficos
Autores: Galián Gay, Laura, Escalona Silva, Roxana Andreina, Teixido Tura, Gisela, Casas Masnou, Guillem, Ferrer-Sistach, Elena, Mitroi, Cristina, González Alujas, Teresa, Gutierrez García-Moreno, Laura, Fernández Galera, Ruben, De Carvalho Negrao Valente, Filipa Xavier, Sao Aviles, Augusto Cesar, Ferreira González, Ignacio, Evangelista Masip, Artur, Guala, Andrea, Rodríguez Palomares, Jose Fernando, Ruiz Muñoz, Aroa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/8157
Acceso en línea:https://hdl.handle.net/11351/8157
http://hdl.handle.net/11351/8157
Access Level:acceso abierto
Palabra clave:Vàlvula aòrtica - Estenosi - Cirurgia
Vàlvula aòrtica - Estenosi - Prognosi
DISEASES::Cardiovascular Diseases::Heart Diseases::Heart Valve Diseases::Aortic Valve Stenosis
Other subheadings::Other subheadings::Other subheadings::/surgery
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis
ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::enfermedades de las válvulas cardíacas::estenosis de la válvula aórtica
Otros calificadores::Otros calificadores::Otros calificadores::/cirugía
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico
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oai_identifier_str oai:recercat.cat:11351/8157
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Prognosis of Paradoxical Low-Flow Low-Gradient Aortic Stenosis: A Severe, Non-critical Form, With Surgical Treatment Benefits
title Prognosis of Paradoxical Low-Flow Low-Gradient Aortic Stenosis: A Severe, Non-critical Form, With Surgical Treatment Benefits
spellingShingle Prognosis of Paradoxical Low-Flow Low-Gradient Aortic Stenosis: A Severe, Non-critical Form, With Surgical Treatment Benefits
Galián Gay, Laura
Vàlvula aòrtica - Estenosi - Cirurgia
Vàlvula aòrtica - Estenosi - Prognosi
DISEASES::Cardiovascular Diseases::Heart Diseases::Heart Valve Diseases::Aortic Valve Stenosis
Other subheadings::Other subheadings::Other subheadings::/surgery
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis
ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::enfermedades de las válvulas cardíacas::estenosis de la válvula aórtica
Otros calificadores::Otros calificadores::Otros calificadores::/cirugía
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico
title_short Prognosis of Paradoxical Low-Flow Low-Gradient Aortic Stenosis: A Severe, Non-critical Form, With Surgical Treatment Benefits
title_full Prognosis of Paradoxical Low-Flow Low-Gradient Aortic Stenosis: A Severe, Non-critical Form, With Surgical Treatment Benefits
title_fullStr Prognosis of Paradoxical Low-Flow Low-Gradient Aortic Stenosis: A Severe, Non-critical Form, With Surgical Treatment Benefits
title_full_unstemmed Prognosis of Paradoxical Low-Flow Low-Gradient Aortic Stenosis: A Severe, Non-critical Form, With Surgical Treatment Benefits
title_sort Prognosis of Paradoxical Low-Flow Low-Gradient Aortic Stenosis: A Severe, Non-critical Form, With Surgical Treatment Benefits
dc.creator.none.fl_str_mv Galián Gay, Laura
Escalona Silva, Roxana Andreina
Teixido Tura, Gisela
Casas Masnou, Guillem
Ferrer-Sistach, Elena
Mitroi, Cristina
González Alujas, Teresa
Gutierrez García-Moreno, Laura
Fernández Galera, Ruben
De Carvalho Negrao Valente, Filipa Xavier
Sao Aviles, Augusto Cesar
Ferreira González, Ignacio
Evangelista Masip, Artur
Guala, Andrea
Rodríguez Palomares, Jose Fernando
Ruiz Muñoz, Aroa
author Galián Gay, Laura
author_facet Galián Gay, Laura
Escalona Silva, Roxana Andreina
Teixido Tura, Gisela
Casas Masnou, Guillem
Ferrer-Sistach, Elena
Mitroi, Cristina
González Alujas, Teresa
Gutierrez García-Moreno, Laura
Fernández Galera, Ruben
De Carvalho Negrao Valente, Filipa Xavier
Sao Aviles, Augusto Cesar
Ferreira González, Ignacio
Evangelista Masip, Artur
Guala, Andrea
Rodríguez Palomares, Jose Fernando
Ruiz Muñoz, Aroa
author_role author
author2 Escalona Silva, Roxana Andreina
Teixido Tura, Gisela
Casas Masnou, Guillem
Ferrer-Sistach, Elena
Mitroi, Cristina
González Alujas, Teresa
Gutierrez García-Moreno, Laura
Fernández Galera, Ruben
De Carvalho Negrao Valente, Filipa Xavier
Sao Aviles, Augusto Cesar
Ferreira González, Ignacio
Evangelista Masip, Artur
Guala, Andrea
Rodríguez Palomares, Jose Fernando
Ruiz Muñoz, Aroa
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Galian-Gay L, Escalona Silva RA, Teixidó-Turà G, Casas G, González-Alujas T, Gutiérrez L, Fernandez-Galera R, Valente F, Guala A, Ruiz-Muñoz A, Avilés CAS, Palomares JFR, Ferreira I, Evangelista A] Servei de Cardiologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. CIBER-CV, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Ferrer-Sistach E] Department of Cardiology, Hospital Universitari Germans Tries i Pujol, Badalona, Spain. [Mitroi C] Department of Cardiology, Hospital Puerta de Hierro - Majadahonda, Madrid, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Vàlvula aòrtica - Estenosi - Cirurgia
Vàlvula aòrtica - Estenosi - Prognosi
DISEASES::Cardiovascular Diseases::Heart Diseases::Heart Valve Diseases::Aortic Valve Stenosis
Other subheadings::Other subheadings::Other subheadings::/surgery
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis
ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::enfermedades de las válvulas cardíacas::estenosis de la válvula aórtica
Otros calificadores::Otros calificadores::Otros calificadores::/cirugía
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico
topic Vàlvula aòrtica - Estenosi - Cirurgia
Vàlvula aòrtica - Estenosi - Prognosi
DISEASES::Cardiovascular Diseases::Heart Diseases::Heart Valve Diseases::Aortic Valve Stenosis
Other subheadings::Other subheadings::Other subheadings::/surgery
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis
ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::enfermedades de las válvulas cardíacas::estenosis de la válvula aórtica
Otros calificadores::Otros calificadores::Otros calificadores::/cirugía
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico
description Aortic stenosis; Echocardiography; Heart valve disease
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/8157
http://hdl.handle.net/11351/8157
url https://hdl.handle.net/11351/8157
http://hdl.handle.net/11351/8157
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Frontiers in Cardiovascular Medicine;9
https://doi.org/10.3389/fcvm.2022.852954
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869403936484491264
spelling Prognosis of Paradoxical Low-Flow Low-Gradient Aortic Stenosis: A Severe, Non-critical Form, With Surgical Treatment BenefitsGalián Gay, LauraEscalona Silva, Roxana AndreinaTeixido Tura, GiselaCasas Masnou, GuillemFerrer-Sistach, ElenaMitroi, CristinaGonzález Alujas, TeresaGutierrez García-Moreno, LauraFernández Galera, RubenDe Carvalho Negrao Valente, Filipa XavierSao Aviles, Augusto CesarFerreira González, IgnacioEvangelista Masip, ArturGuala, AndreaRodríguez Palomares, Jose FernandoRuiz Muñoz, AroaVàlvula aòrtica - Estenosi - CirurgiaVàlvula aòrtica - Estenosi - PrognosiDISEASES::Cardiovascular Diseases::Heart Diseases::Heart Valve Diseases::Aortic Valve StenosisOther subheadings::Other subheadings::Other subheadings::/surgeryANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::PrognosisENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::enfermedades de las válvulas cardíacas::estenosis de la válvula aórticaOtros calificadores::Otros calificadores::Otros calificadores::/cirugíaTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronósticoAortic stenosis; Echocardiography; Heart valve diseaseEstenosis aórtica; Ecocardiografía; Enfermedad de las válvulas del corazónEstenosi aòrtica; Ecocardiografia; Malaltia de les vàlvules cardíaquesObjectives: To determine the risk of mortality and need for aortic valve replacement (AVR) in patients with low-flow low-gradient (LFLG) aortic stenosis (AS). Methods: A longitudinal multicentre study including consecutive patients with severe AS (aortic valve area [AVA] < 1.0 cm2) and normal left ventricular ejection fraction (LVEF). Patients were classified as: high-gradient (HG, mean gradient ≥ 40 mmHg), normal-flow low-gradient (NFLG, mean gradient < 40 mmHg, indexed systolic volume (SVi) > 35 ml/m2) and LFLG (mean gradient < 40 mmHg, SVi ≤ 35 ml/m2). Results: Of 1,391 patients, 147 (10.5%) had LFLG, 752 (54.1%) HG, and 492 (35.4%) NFLG. Echocardiographic parameters of the LFLG group showed similar AVA to the HG group but with less severity in the dimensionless index, calcification, and hypertrophy. The HG group required AVR earlier than NFLG (p < 0.001) and LFLG (p < 0.001), with no differences between LFLG and NFLG groups (p = 0.358). Overall mortality was 27.7% (CI 95% 25.3–30.1) with no differences among groups (p = 0.319). The impact of AVR in terms of overall mortality reduction was observed the most in patients with HG (hazard ratio [HR]: 0.17; 95% CI: 0.12–0.23; p < 0.001), followed by patients with LFLG (HR: 0.25; 95% CI: 0.13–0.49; p < 0.001), and finally patients with NFLG (HR: 0.29; 95% CI: 0.20–0.44; p < 0.001), with a risk reduction of 84, 75, and 71%, respectively. Conclusions: Paradoxical LFLG AS affects 10.5% of severe AS, and has a lower need for AVR than the HG group and similar to the NFLG group, with no differences in mortality. AVR had a lower impact on LFLG AS compared with HG AS. Therefore, the findings of the present study showed LFLG AS to have an intermediate clinical risk profile between the HG and NFHG groups.AGu has received funding from the Spanish Ministry of Science, Innovation and Universities (IJC2018- 037349-I).Frontiers MediaInstitut Català de la Salut[Galian-Gay L, Escalona Silva RA, Teixidó-Turà G, Casas G, González-Alujas T, Gutiérrez L, Fernandez-Galera R, Valente F, Guala A, Ruiz-Muñoz A, Avilés CAS, Palomares JFR, Ferreira I, Evangelista A] Servei de Cardiologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. CIBER-CV, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Ferrer-Sistach E] Department of Cardiology, Hospital Universitari Germans Tries i Pujol, Badalona, Spain. [Mitroi C] Department of Cardiology, Hospital Puerta de Hierro - Majadahonda, Madrid, SpainVall d'Hebron Barcelona Hospital Campus202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/8157http://hdl.handle.net/11351/8157Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésFrontiers in Cardiovascular Medicine;9https://doi.org/10.3389/fcvm.2022.852954Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/81572026-05-29T05:05:01Z
score 15.81155

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