Multiple ion scaffold-based delivery platform for potential application in early stages of bone regeneration

This work was funded by the Government of Catalonia (2017 SGR 708), the Spanish Ministry (Ramón y Cajal fellowship (RYC2018-025977-I) and project RTI2018-096088-J-100 (MINECO/FEDER)), and predoctoral fellowship from Universitat Internacional de Catalunya (UIC).

Detalles Bibliográficos
Autores: Bosch Rué, Elia, Díez-Tercero, Leire, Rodríguez González, Raquel, A. Pérez, Román
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12328/3064
Acceso en línea:http://hdl.handle.net/20.500.12328/3064
https://dx.doi.org/10.3390/ma14247676
Access Level:acceso abierto
Palabra clave:Coure
Cobalt
Calci
Alliberament d'ions
Regeneració òssia
Angiogènesi
Osteogènesi
Propietats antimicrobianes
Cobre
Cobalto
Calcio
Liberación de iones
Regeneración ósea
Angiogénesis
Osteogénesis
Propiedades antimicrobianas
Copper
Calcium
Ion release
Bone regeneration
Angiogenesis
Osteogenesis
Antimicrobial properties
616.3
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oai_identifier_str oai:recercat.cat:20.500.12328/3064
network_acronym_str ES
network_name_str España
repository_id_str
spelling Multiple ion scaffold-based delivery platform for potential application in early stages of bone regenerationBosch Rué, EliaDíez-Tercero, LeireRodríguez González, RaquelA. Pérez, RománCoureCobaltCalciAlliberament d'ionsRegeneració òssiaAngiogènesiOsteogènesiPropietats antimicrobianesCobreCobaltoCalcioLiberación de ionesRegeneración óseaAngiogénesisOsteogénesisPropiedades antimicrobianasCopperCobaltCalciumIon releaseBone regenerationAngiogenesisOsteogenesisAntimicrobial properties616.3This work was funded by the Government of Catalonia (2017 SGR 708), the Spanish Ministry (Ramón y Cajal fellowship (RYC2018-025977-I) and project RTI2018-096088-J-100 (MINECO/FEDER)), and predoctoral fellowship from Universitat Internacional de Catalunya (UIC).Bone has the intrinsic capacity to regenerate itself, as long as the damage is small, through the sequential stimulation of specific phases, such as angiogenesis followed by osteogenesis. However, when the damage is extensive it is unable to regenerate and bone tissue engineering is used as an alternative. In this study, we developed a platform to allow the triple ion delivery with sequential delivery capacity to potentially stimulate antibacterial, angiogenic and osteogenic processes. The scaffold-based platform consisted of alginate/hydroxyapatite (HA) microparticles embedded in alginate fibers. Firstly, microparticles were developed using different ratios of alginate:HA using the spraying method, resulting in a high reproducibility of the technique. Microparticle size between 100–300 µm and ratio 1:40 resulted in a more spherical morphology and were selected for their incorporation into alginate fiber. Different amounts of copper and cobalt were added with the microparticles and alginate fiber, respectively, were used as model ions which could eventually modulate and mimic antimicrobial and angiogenic processes. Moreover, calcium ion was also incorporated in both, in order to provide the system with potential osteogenic properties together with HA. The multiple delivery of copper, cobalt and calcium released were in the therapeutic range as measured by induced coupled plasma (ICP), providing a promising delivery strategy for tissue engineering.info:eu-repo/semantics/publishedVersionMDPI2021info:eu-repo/semantics/article16http://hdl.handle.net/20.500.12328/3064https://dx.doi.org/10.3390/ma14247676reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésMaterials14;24info:eu-repo/grantAgreement/ES/2PE/RTI2018-096088-J-100info:eu-repo/grantAgreement/ES/2PE/RYC2018-​025977-IThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12328/30642026-05-29T05:05:01Z
dc.title.none.fl_str_mv Multiple ion scaffold-based delivery platform for potential application in early stages of bone regeneration
title Multiple ion scaffold-based delivery platform for potential application in early stages of bone regeneration
spellingShingle Multiple ion scaffold-based delivery platform for potential application in early stages of bone regeneration
Bosch Rué, Elia
Coure
Cobalt
Calci
Alliberament d'ions
Regeneració òssia
Angiogènesi
Osteogènesi
Propietats antimicrobianes
Cobre
Cobalto
Calcio
Liberación de iones
Regeneración ósea
Angiogénesis
Osteogénesis
Propiedades antimicrobianas
Copper
Cobalt
Calcium
Ion release
Bone regeneration
Angiogenesis
Osteogenesis
Antimicrobial properties
616.3
title_short Multiple ion scaffold-based delivery platform for potential application in early stages of bone regeneration
title_full Multiple ion scaffold-based delivery platform for potential application in early stages of bone regeneration
title_fullStr Multiple ion scaffold-based delivery platform for potential application in early stages of bone regeneration
title_full_unstemmed Multiple ion scaffold-based delivery platform for potential application in early stages of bone regeneration
title_sort Multiple ion scaffold-based delivery platform for potential application in early stages of bone regeneration
dc.creator.none.fl_str_mv Bosch Rué, Elia
Díez-Tercero, Leire
Rodríguez González, Raquel
A. Pérez, Román
author Bosch Rué, Elia
author_facet Bosch Rué, Elia
Díez-Tercero, Leire
Rodríguez González, Raquel
A. Pérez, Román
author_role author
author2 Díez-Tercero, Leire
Rodríguez González, Raquel
A. Pérez, Román
author2_role author
author
author
dc.subject.none.fl_str_mv Coure
Cobalt
Calci
Alliberament d'ions
Regeneració òssia
Angiogènesi
Osteogènesi
Propietats antimicrobianes
Cobre
Cobalto
Calcio
Liberación de iones
Regeneración ósea
Angiogénesis
Osteogénesis
Propiedades antimicrobianas
Copper
Cobalt
Calcium
Ion release
Bone regeneration
Angiogenesis
Osteogenesis
Antimicrobial properties
616.3
topic Coure
Cobalt
Calci
Alliberament d'ions
Regeneració òssia
Angiogènesi
Osteogènesi
Propietats antimicrobianes
Cobre
Cobalto
Calcio
Liberación de iones
Regeneración ósea
Angiogénesis
Osteogénesis
Propiedades antimicrobianas
Copper
Cobalt
Calcium
Ion release
Bone regeneration
Angiogenesis
Osteogenesis
Antimicrobial properties
616.3
description This work was funded by the Government of Catalonia (2017 SGR 708), the Spanish Ministry (Ramón y Cajal fellowship (RYC2018-025977-I) and project RTI2018-096088-J-100 (MINECO/FEDER)), and predoctoral fellowship from Universitat Internacional de Catalunya (UIC).
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12328/3064
https://dx.doi.org/10.3390/ma14247676
url http://hdl.handle.net/20.500.12328/3064
https://dx.doi.org/10.3390/ma14247676
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Materials
14;24
info:eu-repo/grantAgreement/ES/2PE/RTI2018-096088-J-100
info:eu-repo/grantAgreement/ES/2PE/RYC2018-​025977-I
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 16
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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