Predictors of long-term adherence to continuous positive airway pressure in patients with obstructive sleep apnea and cardiovascular disease

Study Objectives: Poor adherence to continuous positive airway pressure (CPAP) commonly affects therapeutic response in obstructive sleep apnea (OSA). We aimed to determine predictors of adherence to CPAP among participants of the Sleep Apnea and cardioVascular Endpoints (SAVE) trial. Methods: SAVE...

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Autores: Van Ryswyk, E, Anderson, CS, Antic, NA, Barbe, F, Bittencourt, L, Freed, R, Heeley, E, Liu, ZH, Loffler, KA, Lorenzi, G, Luo, YM, Margalef, MJM, McEvoy, RD, Mediano, O, Mukherjee, S, Ou, Q, Woodman, R, Zhang, XL, Chai-Coetzer, CL
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p2897
Acceso en línea:https://i3pt.portalinvestigacion.com/publicaciones/2897
Access Level:acceso abierto
Palabra clave:sleep apnea
obstructive
continuous positive airway pressure
patient compliance
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spelling Predictors of long-term adherence to continuous positive airway pressure in patients with obstructive sleep apnea and cardiovascular diseaseVan Ryswyk, EAnderson, CSAntic, NABarbe, FBittencourt, LFreed, RHeeley, ELiu, ZHLoffler, KALorenzi, GLuo, YMMargalef, MJMMcEvoy, RDMediano, OMukherjee, SOu, QWoodman, RZhang, XLChai-Coetzer, CLsleep apneaobstructivecontinuous positive airway pressurepatient complianceStudy Objectives: Poor adherence to continuous positive airway pressure (CPAP) commonly affects therapeutic response in obstructive sleep apnea (OSA). We aimed to determine predictors of adherence to CPAP among participants of the Sleep Apnea and cardioVascular Endpoints (SAVE) trial. Methods: SAVE was an international, randomized, open trial of CPAP plus usual care versus usual care (UC) alone in participants (45-75 years) with co-occurring moderate-to-severe OSA (>= 12 episodes/h of >= 4% oxygen desaturation) and established cardiovascular (CV) disease. Baseline sociodemographic, health and lifestyle factors, OSA symptoms, and 1-month change in daytime sleepiness, as well as CPAP side effects and adherence (during sham screening, titration week, and in the first month), were entered in univariate linear regression analyses to identify predictors of CPAP adherence at 24 months. Variables with p < 0.2 were assessed for inclusion in a multivariate linear mixed model with country, age, and sex included a priori and site as a random effect. Results: Significant univariate predictors of adherence at 24 months in 1,121 participants included: early adherence measures, improvement in daytime sleepiness at 1 month, fixed CPAP pressure, some measures of OSA severity, cardiovascular disease history, breathing pauses, and very loud snoring. While observed adherence varied between countries, adherence during sham screening, initial titration, and the first month of treatment retained independent predictive value in the multivariate model along with fixed CPAP pressure and very loud snoring. Conclusions: Early CPAP adherence had the greatest predictive value for identifying those at highest risk of non-adherence to long-term CPAP therapy.OXFORD UNIV PRESS INC2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/2897SLEEPISSN: 01618105ISSNe: 15509109reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p28972026-06-21T15:30:37Z
dc.title.none.fl_str_mv Predictors of long-term adherence to continuous positive airway pressure in patients with obstructive sleep apnea and cardiovascular disease
title Predictors of long-term adherence to continuous positive airway pressure in patients with obstructive sleep apnea and cardiovascular disease
spellingShingle Predictors of long-term adherence to continuous positive airway pressure in patients with obstructive sleep apnea and cardiovascular disease
Van Ryswyk, E
sleep apnea
obstructive
continuous positive airway pressure
patient compliance
title_short Predictors of long-term adherence to continuous positive airway pressure in patients with obstructive sleep apnea and cardiovascular disease
title_full Predictors of long-term adherence to continuous positive airway pressure in patients with obstructive sleep apnea and cardiovascular disease
title_fullStr Predictors of long-term adherence to continuous positive airway pressure in patients with obstructive sleep apnea and cardiovascular disease
title_full_unstemmed Predictors of long-term adherence to continuous positive airway pressure in patients with obstructive sleep apnea and cardiovascular disease
title_sort Predictors of long-term adherence to continuous positive airway pressure in patients with obstructive sleep apnea and cardiovascular disease
dc.creator.none.fl_str_mv Van Ryswyk, E
Anderson, CS
Antic, NA
Barbe, F
Bittencourt, L
Freed, R
Heeley, E
Liu, ZH
Loffler, KA
Lorenzi, G
Luo, YM
Margalef, MJM
McEvoy, RD
Mediano, O
Mukherjee, S
Ou, Q
Woodman, R
Zhang, XL
Chai-Coetzer, CL
author Van Ryswyk, E
author_facet Van Ryswyk, E
Anderson, CS
Antic, NA
Barbe, F
Bittencourt, L
Freed, R
Heeley, E
Liu, ZH
Loffler, KA
Lorenzi, G
Luo, YM
Margalef, MJM
McEvoy, RD
Mediano, O
Mukherjee, S
Ou, Q
Woodman, R
Zhang, XL
Chai-Coetzer, CL
author_role author
author2 Anderson, CS
Antic, NA
Barbe, F
Bittencourt, L
Freed, R
Heeley, E
Liu, ZH
Loffler, KA
Lorenzi, G
Luo, YM
Margalef, MJM
McEvoy, RD
Mediano, O
Mukherjee, S
Ou, Q
Woodman, R
Zhang, XL
Chai-Coetzer, CL
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv sleep apnea
obstructive
continuous positive airway pressure
patient compliance
topic sleep apnea
obstructive
continuous positive airway pressure
patient compliance
description Study Objectives: Poor adherence to continuous positive airway pressure (CPAP) commonly affects therapeutic response in obstructive sleep apnea (OSA). We aimed to determine predictors of adherence to CPAP among participants of the Sleep Apnea and cardioVascular Endpoints (SAVE) trial. Methods: SAVE was an international, randomized, open trial of CPAP plus usual care versus usual care (UC) alone in participants (45-75 years) with co-occurring moderate-to-severe OSA (>= 12 episodes/h of >= 4% oxygen desaturation) and established cardiovascular (CV) disease. Baseline sociodemographic, health and lifestyle factors, OSA symptoms, and 1-month change in daytime sleepiness, as well as CPAP side effects and adherence (during sham screening, titration week, and in the first month), were entered in univariate linear regression analyses to identify predictors of CPAP adherence at 24 months. Variables with p < 0.2 were assessed for inclusion in a multivariate linear mixed model with country, age, and sex included a priori and site as a random effect. Results: Significant univariate predictors of adherence at 24 months in 1,121 participants included: early adherence measures, improvement in daytime sleepiness at 1 month, fixed CPAP pressure, some measures of OSA severity, cardiovascular disease history, breathing pauses, and very loud snoring. While observed adherence varied between countries, adherence during sham screening, initial titration, and the first month of treatment retained independent predictive value in the multivariate model along with fixed CPAP pressure and very loud snoring. Conclusions: Early CPAP adherence had the greatest predictive value for identifying those at highest risk of non-adherence to long-term CPAP therapy.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/2897
url https://i3pt.portalinvestigacion.com/publicaciones/2897
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv OXFORD UNIV PRESS INC
publisher.none.fl_str_mv OXFORD UNIV PRESS INC
dc.source.none.fl_str_mv SLEEP
ISSN: 01618105
ISSNe: 15509109
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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