MiR-146a Contributes to Thromboinflammation and Recurrence in Young Patients with Acute Myocardial Infarction

Abstract: Studies on older patients have established notable conceptual changes in the etiopatho genesis of acute coronary syndrome (ACS), but little is known about this disease in young patients ( Q4 more frequently had a history of previous stroke (6.1% vs. 1.6%). In turn, rs2431697 did not confer...

Descripción completa

Detalles Bibliográficos
Autores: de los Reyes García, Ascensión M., Rivera Caravaca, José Miguel, Zapata Martínez, Laura, Águila, Sonia, Véliz Martínez, Andrea, García Barberá, Nuria, Gil Pérez, Pablo, Guijarro Carrillo, Pedro J., Orenes Piñero, Esteban, López García, Cecilia, Lozano, María L., Marín, Francisco, Martínez, Constantino, González Conejero, Rocío
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Católica San Antonio de Murcia (UCAM)
Repositorio:RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia
OAI Identifier:oai:repositorio.ucam.edu:10952/10706
Acceso en línea:http://hdl.handle.net/10952/10706
Access Level:acceso abierto
Palabra clave:miR-146a
Thromboinflammation
Acute Myocardial infarction
Recurrence
Young Patients
id ES_1734a1ec29a4e248155bbd28cd16b0b7
oai_identifier_str oai:repositorio.ucam.edu:10952/10706
network_acronym_str ES
network_name_str España
repository_id_str
spelling MiR-146a Contributes to Thromboinflammation and Recurrence in Young Patients with Acute Myocardial Infarctionde los Reyes García, Ascensión M.Rivera Caravaca, José MiguelZapata Martínez, LauraÁguila, SoniaVéliz Martínez, AndreaGarcía Barberá, NuriaGil Pérez, PabloGuijarro Carrillo, Pedro J.Orenes Piñero, EstebanLópez García, CeciliaLozano, María L.Marín, FranciscoMartínez, ConstantinoGonzález Conejero, RocíomiR-146aThromboinflammationAcute Myocardial infarctionRecurrenceYoung PatientsAbstract: Studies on older patients have established notable conceptual changes in the etiopatho genesis of acute coronary syndrome (ACS), but little is known about this disease in young patients ( Q4 more frequently had a history of previous stroke (6.1% vs. 1.6%). In turn, rs2431697 did not confer increased risk for the onset of ACS, but T carriers had significantly higher levels of NET markers. By groups, we found that cfDNA levels were similarly higher in all patients, but citH3–DNA was especially higher in G1, suggesting that in plasma, this marker may be attenuated over time. Finally, patients from G2 with the worst markers (cfDNA and citH3–DNA > Q2 and T allele) had a two-fold increased risk of a new ischemic event at 2-year follow-up. In conclusion, our data confirm that ACS is younger onset with thromboinflammatory disease. In addition, these data consolidate rs2431697 as a silent proinflammatory factor predisposing to NETosis, and to a higher rate of adverse events in different cardiovascular diseasesResumen: Los estudios en pacientes de mayor edad han establecido cambios conceptuales importantes en la etiopatogenia del síndrome coronario agudo (SCA), pero se conoce poco sobre esta enfermedad en pacientes jóvenes. El cuartil 4 (Q4) presentó con mayor frecuencia antecedentes de ictus previo (6,1 % frente a 1,6 %). Por otro lado, el polimorfismo rs2431697 no se asoció con un mayor riesgo de aparición de SCA, aunque los portadores del alelo T mostraron niveles significativamente más altos de marcadores de NETs. Por grupos, se observó que los niveles de cfDNA eran similares y elevados en todos los pacientes, mientras que citH3–DNA fue especialmente mayor en el grupo 1 (G1), lo que sugiere que, en plasma, este marcador podría atenuarse con el tiempo. Finalmente, los pacientes del grupo 2 (G2) con los peores marcadores (cfDNA y citH3–DNA > Q2 y alelo T) presentaron un riesgo doble de un nuevo evento isquémico a los 2 años de seguimiento. En conclusión, nuestros datos confirman que el SCA en pacientes jóvenes se caracteriza por ser una enfermedad tromboinflamatoria. Además, estos datos consolidan a rs2431697 como un factor proinflamatorio silencioso que predispone a la NETosis y a una mayor tasa de eventos adversos en diversas enfermedades cardiovasculares.Medicina2022info:eu-repo/semantics/articlehttp://hdl.handle.net/10952/10706reponame:RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murciainstname:Universidad Católica San Antonio de Murcia (UCAM)Inglésinfo:eu-repo/semantics/openAccessoai:repositorio.ucam.edu:10952/107062026-06-07T18:35:21Z
dc.title.none.fl_str_mv MiR-146a Contributes to Thromboinflammation and Recurrence in Young Patients with Acute Myocardial Infarction
title MiR-146a Contributes to Thromboinflammation and Recurrence in Young Patients with Acute Myocardial Infarction
spellingShingle MiR-146a Contributes to Thromboinflammation and Recurrence in Young Patients with Acute Myocardial Infarction
de los Reyes García, Ascensión M.
miR-146a
Thromboinflammation
Acute Myocardial infarction
Recurrence
Young Patients
title_short MiR-146a Contributes to Thromboinflammation and Recurrence in Young Patients with Acute Myocardial Infarction
title_full MiR-146a Contributes to Thromboinflammation and Recurrence in Young Patients with Acute Myocardial Infarction
title_fullStr MiR-146a Contributes to Thromboinflammation and Recurrence in Young Patients with Acute Myocardial Infarction
title_full_unstemmed MiR-146a Contributes to Thromboinflammation and Recurrence in Young Patients with Acute Myocardial Infarction
title_sort MiR-146a Contributes to Thromboinflammation and Recurrence in Young Patients with Acute Myocardial Infarction
dc.creator.none.fl_str_mv de los Reyes García, Ascensión M.
Rivera Caravaca, José Miguel
Zapata Martínez, Laura
Águila, Sonia
Véliz Martínez, Andrea
García Barberá, Nuria
Gil Pérez, Pablo
Guijarro Carrillo, Pedro J.
Orenes Piñero, Esteban
López García, Cecilia
Lozano, María L.
Marín, Francisco
Martínez, Constantino
González Conejero, Rocío
author de los Reyes García, Ascensión M.
author_facet de los Reyes García, Ascensión M.
Rivera Caravaca, José Miguel
Zapata Martínez, Laura
Águila, Sonia
Véliz Martínez, Andrea
García Barberá, Nuria
Gil Pérez, Pablo
Guijarro Carrillo, Pedro J.
Orenes Piñero, Esteban
López García, Cecilia
Lozano, María L.
Marín, Francisco
Martínez, Constantino
González Conejero, Rocío
author_role author
author2 Rivera Caravaca, José Miguel
Zapata Martínez, Laura
Águila, Sonia
Véliz Martínez, Andrea
García Barberá, Nuria
Gil Pérez, Pablo
Guijarro Carrillo, Pedro J.
Orenes Piñero, Esteban
López García, Cecilia
Lozano, María L.
Marín, Francisco
Martínez, Constantino
González Conejero, Rocío
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv miR-146a
Thromboinflammation
Acute Myocardial infarction
Recurrence
Young Patients
topic miR-146a
Thromboinflammation
Acute Myocardial infarction
Recurrence
Young Patients
description Abstract: Studies on older patients have established notable conceptual changes in the etiopatho genesis of acute coronary syndrome (ACS), but little is known about this disease in young patients ( Q4 more frequently had a history of previous stroke (6.1% vs. 1.6%). In turn, rs2431697 did not confer increased risk for the onset of ACS, but T carriers had significantly higher levels of NET markers. By groups, we found that cfDNA levels were similarly higher in all patients, but citH3–DNA was especially higher in G1, suggesting that in plasma, this marker may be attenuated over time. Finally, patients from G2 with the worst markers (cfDNA and citH3–DNA > Q2 and T allele) had a two-fold increased risk of a new ischemic event at 2-year follow-up. In conclusion, our data confirm that ACS is younger onset with thromboinflammatory disease. In addition, these data consolidate rs2431697 as a silent proinflammatory factor predisposing to NETosis, and to a higher rate of adverse events in different cardiovascular diseases
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10952/10706
url http://hdl.handle.net/10952/10706
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia
instname:Universidad Católica San Antonio de Murcia (UCAM)
instname_str Universidad Católica San Antonio de Murcia (UCAM)
reponame_str RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia
collection RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869403906451177472
score 15,812429

Similares en LA Referencia