The endocannabinoid system in guarding against fear, anxiety and stress

The endocannabinoid (eCB) system has emerged as a central integrator linking the perception of external and internal stimuli to distinct neurophysiological and behavioural outcomes (such as fear reaction, anxiety and stress-coping), thus allowing an organism to adapt to its changing environment. eCB...

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Autores: Lutz, Beat, Marsicano, Giovanni, Maldonado, Rafael, 1961-, Hillard, Cecilia J.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/34794
Acceso en línea:http://hdl.handle.net/10230/34794
http://dx.doi.org/10.1038/nrn4036
Access Level:acceso abierto
Palabra clave:Amygdala
Anxiety
Fear conditioning
Stress and resilience
Synaptic plasticity
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spelling The endocannabinoid system in guarding against fear, anxiety and stressLutz, BeatMarsicano, GiovanniMaldonado, Rafael, 1961-Hillard, Cecilia J.AmygdalaAnxietyFear conditioningStress and resilienceSynaptic plasticityThe endocannabinoid (eCB) system has emerged as a central integrator linking the perception of external and internal stimuli to distinct neurophysiological and behavioural outcomes (such as fear reaction, anxiety and stress-coping), thus allowing an organism to adapt to its changing environment. eCB signalling seems to determine the value of fear-evoking stimuli and to tune appropriate behavioural responses, which are essential for the organism's long-term viability, homeostasis and stress resilience; and dysregulation of eCB signalling can lead to psychiatric disorders. An understanding of the underlying neural cell populations and cellular processes enables the development of therapeutic strategies to mitigate behavioural maladaptation.B.L. was supported by the German Research Foundation (SFB TRR 58, CRC 1080 and FOR 926); G.M. by the Institut national de la santé et de la recherche médicale (INSERM), the European Commission Seventh Framework Programme (REPROBESITY, HEALTH-F2-2008-223713, PAINCAGE and HEALTH-2014-603191), the European Research Council (Endofood, ERC-2010-StG−260515, CannaPreg and ERC-2014-PoC-640923), the Fondation pour la Recherche Medicale (DRM20101220445), the Human Frontiers Science Program, Region Aquitaine, Agence Nationale de la Recherche (ANR Blanc NeuroNutriSens ANR-13-BSV4-0006 and BRAIN ANR-10-LABX-0043); R.M. by the grants SAF2014-59648P, RETICS-RTA#RD12/0028/0023, AGAUR#2014-SGR-1547 and Health-F2-2013-602891; and C.J.H. by the US National Institutes of Health grants DA038663, DA026996 and MH102838.Nature Publishing Group201820182015info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/34794http://dx.doi.org/10.1038/nrn4036reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésNature Reviews Neuroscience. 2015 Dec;16(12):705-18info:eu-repo/grantAgreement/EC/FP7/223713info:eu-repo/grantAgreement/EC/FP7/603191info:eu-repo/grantAgreement/EC/FP7/260515info:eu-repo/grantAgreement/EC/H2020/640923info:eu-repo/grantAgreement/ES/SAF2014-59648-P/info:eu-repo/grantAgreement/EC/FP7/602891© Nature Publishing Group. http://dx.doi.org/10.1038/nrn4036info:eu-repo/semantics/openAccessoai:recercat.cat:10230/347942026-05-29T05:05:01Z
dc.title.none.fl_str_mv The endocannabinoid system in guarding against fear, anxiety and stress
title The endocannabinoid system in guarding against fear, anxiety and stress
spellingShingle The endocannabinoid system in guarding against fear, anxiety and stress
Lutz, Beat
Amygdala
Anxiety
Fear conditioning
Stress and resilience
Synaptic plasticity
title_short The endocannabinoid system in guarding against fear, anxiety and stress
title_full The endocannabinoid system in guarding against fear, anxiety and stress
title_fullStr The endocannabinoid system in guarding against fear, anxiety and stress
title_full_unstemmed The endocannabinoid system in guarding against fear, anxiety and stress
title_sort The endocannabinoid system in guarding against fear, anxiety and stress
dc.creator.none.fl_str_mv Lutz, Beat
Marsicano, Giovanni
Maldonado, Rafael, 1961-
Hillard, Cecilia J.
author Lutz, Beat
author_facet Lutz, Beat
Marsicano, Giovanni
Maldonado, Rafael, 1961-
Hillard, Cecilia J.
author_role author
author2 Marsicano, Giovanni
Maldonado, Rafael, 1961-
Hillard, Cecilia J.
author2_role author
author
author
dc.subject.none.fl_str_mv Amygdala
Anxiety
Fear conditioning
Stress and resilience
Synaptic plasticity
topic Amygdala
Anxiety
Fear conditioning
Stress and resilience
Synaptic plasticity
description The endocannabinoid (eCB) system has emerged as a central integrator linking the perception of external and internal stimuli to distinct neurophysiological and behavioural outcomes (such as fear reaction, anxiety and stress-coping), thus allowing an organism to adapt to its changing environment. eCB signalling seems to determine the value of fear-evoking stimuli and to tune appropriate behavioural responses, which are essential for the organism's long-term viability, homeostasis and stress resilience; and dysregulation of eCB signalling can lead to psychiatric disorders. An understanding of the underlying neural cell populations and cellular processes enables the development of therapeutic strategies to mitigate behavioural maladaptation.
publishDate 2015
dc.date.none.fl_str_mv 2015
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/34794
http://dx.doi.org/10.1038/nrn4036
url http://hdl.handle.net/10230/34794
http://dx.doi.org/10.1038/nrn4036
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Nature Reviews Neuroscience. 2015 Dec;16(12):705-18
info:eu-repo/grantAgreement/EC/FP7/223713
info:eu-repo/grantAgreement/EC/FP7/603191
info:eu-repo/grantAgreement/EC/FP7/260515
info:eu-repo/grantAgreement/EC/H2020/640923
info:eu-repo/grantAgreement/ES/SAF2014-59648-P/
info:eu-repo/grantAgreement/EC/FP7/602891
dc.rights.none.fl_str_mv © Nature Publishing Group. http://dx.doi.org/10.1038/nrn4036
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Nature Publishing Group. http://dx.doi.org/10.1038/nrn4036
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
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