Osteoimmune Properties of Mesoporous Bioactive Nanospheres: A Study on T Helper Lymphocytes

Bioactive mesoporous glass nanospheres (nanoMBGs) charged with antiosteoporotic drugs have great potential for the treatment of osteoporosis and fracture prevention. In this scenario, cells of the immune system are essential both in the development of disease and in their potential to stimulate ther...

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Detalles Bibliográficos
Autores: Casarrubios Molina, Laura, Cicuéndez Maroto, Mónica, Vallet Regí, María Dulce Nombre, Portolés Pérez, María Teresa, Arcos Navarrete, Daniel, Feito Castellano, María José
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/106847
Acceso en línea:https://hdl.handle.net/20.500.14352/106847
Access Level:acceso abierto
Palabra clave:615:54
615.31
mesoporous bioactive glass
nanospheres
osteoimmunology
lymphocytes
ipriflavone
osteoporosis
Química farmaceútica
23 Química
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oai_identifier_str oai:docta.ucm.es:20.500.14352/106847
network_acronym_str ES
network_name_str España
repository_id_str
spelling Osteoimmune Properties of Mesoporous Bioactive Nanospheres: A Study on T Helper LymphocytesCasarrubios Molina, LauraCicuéndez Maroto, MónicaVallet Regí, María Dulce NombrePortolés Pérez, María TeresaArcos Navarrete, DanielFeito Castellano, María José615:54615.31mesoporous bioactive glassnanospheresosteoimmunologylymphocytesipriflavoneosteoporosisQuímica farmaceútica23 QuímicaBioactive mesoporous glass nanospheres (nanoMBGs) charged with antiosteoporotic drugs have great potential for the treatment of osteoporosis and fracture prevention. In this scenario, cells of the immune system are essential both in the development of disease and in their potential to stimulate therapeutic effects. In the present work, we hypothesize that nanoMBGs loaded with ipriflavone can exert a positive osteoimmune effect. With this objective, we assessed the effects of non-loaded and ipriflavone-loaded nanoparticles (nanoMBGs and nanoMBG-IPs, respectively) on CD4+ Th2 lymphocytes because this kind of cell is implicated in the inhibition of osseous loss by reducing the RANKL/OPG relationship through the secretion of cytokines. The results indicate that nanoMBGs enter efficiently in CD4+ Th2 lymphocytes, mainly through phagocytosis and clathrindependent mechanisms, without affecting the function of these T cells or inducing inflammatory mediators or oxidative stress, thus maintaining the reparative Th2 phenotype. Furthermore, the incorporation of the anti-osteoporotic drug ipriflavone reduces the potential unwanted inflammatory response by decreasing the presence of ROS and stimulating intracellular anti-inflammatory cytokine release like IL-4. These results evidenced that nanoMBG loaded with ipriflavone exerts a positive osteoimmune effect.MDPIUniversidad Complutense de Madrid20232023-07-2620232023-07-26journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/106847reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-117091RB-I00 BIOCERAMICAS NANOESTRUCTURADAS CON APLICACIONES EN INFECCION OSEA Y NEOPLASIA HEMATOLOGICAMinisterio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 Not available MAT2016–75611-R MAT2016–75611-Ropen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1068472026-06-02T12:44:21Z
dc.title.none.fl_str_mv Osteoimmune Properties of Mesoporous Bioactive Nanospheres: A Study on T Helper Lymphocytes
title Osteoimmune Properties of Mesoporous Bioactive Nanospheres: A Study on T Helper Lymphocytes
spellingShingle Osteoimmune Properties of Mesoporous Bioactive Nanospheres: A Study on T Helper Lymphocytes
Casarrubios Molina, Laura
615:54
615.31
mesoporous bioactive glass
nanospheres
osteoimmunology
lymphocytes
ipriflavone
osteoporosis
Química farmaceútica
23 Química
title_short Osteoimmune Properties of Mesoporous Bioactive Nanospheres: A Study on T Helper Lymphocytes
title_full Osteoimmune Properties of Mesoporous Bioactive Nanospheres: A Study on T Helper Lymphocytes
title_fullStr Osteoimmune Properties of Mesoporous Bioactive Nanospheres: A Study on T Helper Lymphocytes
title_full_unstemmed Osteoimmune Properties of Mesoporous Bioactive Nanospheres: A Study on T Helper Lymphocytes
title_sort Osteoimmune Properties of Mesoporous Bioactive Nanospheres: A Study on T Helper Lymphocytes
dc.creator.none.fl_str_mv Casarrubios Molina, Laura
Cicuéndez Maroto, Mónica
Vallet Regí, María Dulce Nombre
Portolés Pérez, María Teresa
Arcos Navarrete, Daniel
Feito Castellano, María José
author Casarrubios Molina, Laura
author_facet Casarrubios Molina, Laura
Cicuéndez Maroto, Mónica
Vallet Regí, María Dulce Nombre
Portolés Pérez, María Teresa
Arcos Navarrete, Daniel
Feito Castellano, María José
author_role author
author2 Cicuéndez Maroto, Mónica
Vallet Regí, María Dulce Nombre
Portolés Pérez, María Teresa
Arcos Navarrete, Daniel
Feito Castellano, María José
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 615:54
615.31
mesoporous bioactive glass
nanospheres
osteoimmunology
lymphocytes
ipriflavone
osteoporosis
Química farmaceútica
23 Química
topic 615:54
615.31
mesoporous bioactive glass
nanospheres
osteoimmunology
lymphocytes
ipriflavone
osteoporosis
Química farmaceútica
23 Química
description Bioactive mesoporous glass nanospheres (nanoMBGs) charged with antiosteoporotic drugs have great potential for the treatment of osteoporosis and fracture prevention. In this scenario, cells of the immune system are essential both in the development of disease and in their potential to stimulate therapeutic effects. In the present work, we hypothesize that nanoMBGs loaded with ipriflavone can exert a positive osteoimmune effect. With this objective, we assessed the effects of non-loaded and ipriflavone-loaded nanoparticles (nanoMBGs and nanoMBG-IPs, respectively) on CD4+ Th2 lymphocytes because this kind of cell is implicated in the inhibition of osseous loss by reducing the RANKL/OPG relationship through the secretion of cytokines. The results indicate that nanoMBGs enter efficiently in CD4+ Th2 lymphocytes, mainly through phagocytosis and clathrindependent mechanisms, without affecting the function of these T cells or inducing inflammatory mediators or oxidative stress, thus maintaining the reparative Th2 phenotype. Furthermore, the incorporation of the anti-osteoporotic drug ipriflavone reduces the potential unwanted inflammatory response by decreasing the presence of ROS and stimulating intracellular anti-inflammatory cytokine release like IL-4. These results evidenced that nanoMBG loaded with ipriflavone exerts a positive osteoimmune effect.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-07-26
2023
2023-07-26
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/106847
url https://hdl.handle.net/20.500.14352/106847
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-117091RB-I00 BIOCERAMICAS NANOESTRUCTURADAS CON APLICACIONES EN INFECCION OSEA Y NEOPLASIA HEMATOLOGICA
Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 Not available MAT2016–75611-R MAT2016–75611-R
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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