Reduced contextual discrimination following alcohol consumption or MDMA administration in mice.

The recreational drugs, alcohol and 3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") have both been shown to cause immune activation in vivo, and they are linked to cognitive impairment and anxiety-like behaviors in rodents. The neuronal effects of these drugs in the hippocampal...

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Autores: Johansson, Emily M., García-Gutiérrez, María S., Moscoso Castro, Maria, 1988-, Manzanares, Jorge, Valverde Granados, Olga
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/25590
Acceso en línea:http://hdl.handle.net/10230/25590
http://dx.doi.org/10.1371/journal.pone.0142978
Access Level:acceso abierto
Palabra clave:Drogues -- Efectes secundaris
Rates (Animals de laboratori)
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spelling Reduced contextual discrimination following alcohol consumption or MDMA administration in mice.Johansson, Emily M.García-Gutiérrez, María S.Moscoso Castro, Maria, 1988-Manzanares, JorgeValverde Granados, OlgaDrogues -- Efectes secundarisRates (Animals de laboratori)The recreational drugs, alcohol and 3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") have both been shown to cause immune activation in vivo, and they are linked to cognitive impairment and anxiety-like behaviors in rodents. The neuronal effects of these drugs in the hippocampal area, an area that has been a focus of studies aiming to explain the mechanisms underlying anxiety related-disorders, remains poorly understood. Therefore we investigated the specific inflammatory impact of alcohol and MDMA on this area of the brain and on a hippocampal-related behavioral task. We centered our study on two inflammatory factors linked to anxiety-related disorders, namely Interleukin-1β (IL-1β) and brain-derived neurotrophic factor (BDNF). We subjected drug-consuming mice to a battery of behavioral tests to evaluate general activity, anxiety-like and depressive-live behaviors. We then introduced them to a contextual fear discrimination task and immune-related effects were examined by immunohistochemical and biochemical studies. Our results suggest that there is a relationship between the induction of immune activated pathways by voluntary alcohol consumption and a high-dose MDMA. Furthermore, the ability of mice to perform a contextual fear discrimination task was impaired by drug consumption and we report long term inflammatory alterations in the hippocampus even several weeks after drug intake. This information will be helpful for discovering new selective drug targets, and to develop treatments and preventive approaches for patients with anxiety-related disorders.This study was supported by Ministery of Economy (SAF2013-41761-R-FEDER), Ministery of Health (Retic-ISCIII-FEDER-RD12/0028/0024- and Plan Nacional sobre Drogas - 2014/020), and Generalitat de Catalunya (2014SGR34) to Olga Valverde; and Ministery of Health (Retic-ISCIIIFEDER-RD06/0001/1004, RD12/0028/0019) to Jorge Manzanares. Emily Johansson was a recipient of a fellowship from Stiftelsen Olle Engkvist Byggmästare and Bodil Torkelssons stiftelse.The study was supported by Instituto de Salud Carlos III [ISCIII; FIS PI11/00210, FIS PI14/ 00290 and Ministerio de de Economía y Competitividad (PSI2011-28349)] and co-funded by Fondos Europeos de Desarrollo Regional (FEDER) funds - a way to build Europe. José C. FernándezGarcía is the recipient of a research contract from Servicio Andaluz de Salud (SAS) (B-0033-2014). CIBERobn and CIBERSAM are both initiatives of ISCIII.Public Library of Science201620162015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/25590http://dx.doi.org/10.1371/journal.pone.0142978reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésPLoS One. 2015 Nov 13;10(11):e0142978info:eu-repo/grantAgreement/ES/1PE/SAF2013-41761© 2015 Johansson et al. This is an open access article distributed under the terms of the http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/255902026-06-12T07:21:37Z
dc.title.none.fl_str_mv Reduced contextual discrimination following alcohol consumption or MDMA administration in mice.
title Reduced contextual discrimination following alcohol consumption or MDMA administration in mice.
spellingShingle Reduced contextual discrimination following alcohol consumption or MDMA administration in mice.
Johansson, Emily M.
Drogues -- Efectes secundaris
Rates (Animals de laboratori)
title_short Reduced contextual discrimination following alcohol consumption or MDMA administration in mice.
title_full Reduced contextual discrimination following alcohol consumption or MDMA administration in mice.
title_fullStr Reduced contextual discrimination following alcohol consumption or MDMA administration in mice.
title_full_unstemmed Reduced contextual discrimination following alcohol consumption or MDMA administration in mice.
title_sort Reduced contextual discrimination following alcohol consumption or MDMA administration in mice.
dc.creator.none.fl_str_mv Johansson, Emily M.
García-Gutiérrez, María S.
Moscoso Castro, Maria, 1988-
Manzanares, Jorge
Valverde Granados, Olga
author Johansson, Emily M.
author_facet Johansson, Emily M.
García-Gutiérrez, María S.
Moscoso Castro, Maria, 1988-
Manzanares, Jorge
Valverde Granados, Olga
author_role author
author2 García-Gutiérrez, María S.
Moscoso Castro, Maria, 1988-
Manzanares, Jorge
Valverde Granados, Olga
author2_role author
author
author
author
dc.subject.none.fl_str_mv Drogues -- Efectes secundaris
Rates (Animals de laboratori)
topic Drogues -- Efectes secundaris
Rates (Animals de laboratori)
description The recreational drugs, alcohol and 3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") have both been shown to cause immune activation in vivo, and they are linked to cognitive impairment and anxiety-like behaviors in rodents. The neuronal effects of these drugs in the hippocampal area, an area that has been a focus of studies aiming to explain the mechanisms underlying anxiety related-disorders, remains poorly understood. Therefore we investigated the specific inflammatory impact of alcohol and MDMA on this area of the brain and on a hippocampal-related behavioral task. We centered our study on two inflammatory factors linked to anxiety-related disorders, namely Interleukin-1β (IL-1β) and brain-derived neurotrophic factor (BDNF). We subjected drug-consuming mice to a battery of behavioral tests to evaluate general activity, anxiety-like and depressive-live behaviors. We then introduced them to a contextual fear discrimination task and immune-related effects were examined by immunohistochemical and biochemical studies. Our results suggest that there is a relationship between the induction of immune activated pathways by voluntary alcohol consumption and a high-dose MDMA. Furthermore, the ability of mice to perform a contextual fear discrimination task was impaired by drug consumption and we report long term inflammatory alterations in the hippocampus even several weeks after drug intake. This information will be helpful for discovering new selective drug targets, and to develop treatments and preventive approaches for patients with anxiety-related disorders.
publishDate 2015
dc.date.none.fl_str_mv 2015
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/25590
http://dx.doi.org/10.1371/journal.pone.0142978
url http://hdl.handle.net/10230/25590
http://dx.doi.org/10.1371/journal.pone.0142978
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv PLoS One. 2015 Nov 13;10(11):e0142978
info:eu-repo/grantAgreement/ES/1PE/SAF2013-41761
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
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repository.mail.fl_str_mv
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