Peptides mimicking the β7/β8 loop of HIV'1 reverse transcriptase p51 as “hotspot-targeted” dimerization inhibitors
A conformationally constrained short peptide designed to target a protein−protein interaction hotspot in HIV-1 reverse transcriptase (RT) disrupts p66-p51 interactions and paves the way to the development of novel RT dimerization inhibitors.
| Autores: | , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/218990 |
| Acceso en línea: | http://hdl.handle.net/10261/218990 |
| Access Level: | acceso abierto |
| Palabra clave: | Constrained peptides Dimerization hotspot Dimerization inhibitors HIV reverse transcriptase. |
| Sumario: | A conformationally constrained short peptide designed to target a protein−protein interaction hotspot in HIV-1 reverse transcriptase (RT) disrupts p66-p51 interactions and paves the way to the development of novel RT dimerization inhibitors. |
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