Evaluation of Anticancer Activity of 76 Plant Species Collected in Andalusia (Spain) against Lung Cancer Cells

Every year, cancer kills millions of people around the world. Finding more selective anticancer agents is essential to improve the low survival rates of patients with metastatic cancers. Since the research of natural products is a valuable approach to the discovery of new compounds and the Iberian f...

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Autores: Jiménez González, Víctor, Benítez, Guillermo, Pastor Díaz, Julio Enrique, López Lázaro, Miguel, Calderón Montaño, José Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/161808
Acceso en línea:https://hdl.handle.net/11441/161808
https://doi.org/10.3390/plants12183275
Access Level:acceso abierto
Palabra clave:Cancer
Lung cancer
Selectivity
Xiphion xiphium
Iris xiphium
Iridaceae
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spelling Evaluation of Anticancer Activity of 76 Plant Species Collected in Andalusia (Spain) against Lung Cancer CellsJiménez González, VíctorBenítez, GuillermoPastor Díaz, Julio EnriqueLópez Lázaro, MiguelCalderón Montaño, José ManuelCancerLung cancerSelectivityXiphion xiphiumIris xiphiumIridaceaeEvery year, cancer kills millions of people around the world. Finding more selective anticancer agents is essential to improve the low survival rates of patients with metastatic cancers. Since the research of natural products is a valuable approach to the discovery of new compounds and the Iberian flora offers a rich source of unstudied plants, we have carried out a random screening of 76 plant species from 43 families collected in Andalusia (South of Spain). Using non-malignant cells (HaCaT) and lung cancer cells (A549), we found that the extract from Arum italicum Mill. subsp. italicum (Araceae), Mandragora autumnalis Bertol. (Solanaceae), Rhamnus alaternus L. (Rhamnaceae), and Lomelosia simplex (Desf.) Raf. subsp. dentata (Jord. & Fourr.) Greuter & Burdet (Dipsacaceae) showed selective cytotoxicity against lung cancer cells. Extracts of plant species belonging to the Iridaceae family showed high selective activity against cancer cells, highlighting that the Xiphion xiphium (L.) M.B. Crespo, Mart.-Azorín & Mavrodiev flower extract was more selective against lung cancer cells than the standard anticancer drugs, cisplatin and 5-fluorouracil. This extract also showed modest selective cytotoxicity against bladder carcinoma cells (T24). The number of cells in the G1 phase increased after treatment with the extract from Xiphion xiphium. Our research indicates that various plants are potential sources for the isolation and development of new anticancer drugs.Junta de Andalucía 2017/CTS-657, 2019/CTS-657, 2021/CTS-657Universidad de Sevilla VIPPIT-2019-I.5, VIPPIT-2020-I.5, VIPPIT-2021-IMDPIBiología Vegetal y EcologíaFarmacologíaJunta de AndalucíaUniversidad de Sevilla2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/161808https://doi.org/10.3390/plants12183275reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésPlants, 12 (18), 3275.2017/CTS-6572019/CTS-6572021/CTS-657VIPPIT-2019-I.5VIPPIT-2020-I.5VIPPIT-2021-Ihttps://doi.org/10.3390/plants12183275info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1618082026-06-17T12:51:07Z
dc.title.none.fl_str_mv Evaluation of Anticancer Activity of 76 Plant Species Collected in Andalusia (Spain) against Lung Cancer Cells
title Evaluation of Anticancer Activity of 76 Plant Species Collected in Andalusia (Spain) against Lung Cancer Cells
spellingShingle Evaluation of Anticancer Activity of 76 Plant Species Collected in Andalusia (Spain) against Lung Cancer Cells
Jiménez González, Víctor
Cancer
Lung cancer
Selectivity
Xiphion xiphium
Iris xiphium
Iridaceae
title_short Evaluation of Anticancer Activity of 76 Plant Species Collected in Andalusia (Spain) against Lung Cancer Cells
title_full Evaluation of Anticancer Activity of 76 Plant Species Collected in Andalusia (Spain) against Lung Cancer Cells
title_fullStr Evaluation of Anticancer Activity of 76 Plant Species Collected in Andalusia (Spain) against Lung Cancer Cells
title_full_unstemmed Evaluation of Anticancer Activity of 76 Plant Species Collected in Andalusia (Spain) against Lung Cancer Cells
title_sort Evaluation of Anticancer Activity of 76 Plant Species Collected in Andalusia (Spain) against Lung Cancer Cells
dc.creator.none.fl_str_mv Jiménez González, Víctor
Benítez, Guillermo
Pastor Díaz, Julio Enrique
López Lázaro, Miguel
Calderón Montaño, José Manuel
author Jiménez González, Víctor
author_facet Jiménez González, Víctor
Benítez, Guillermo
Pastor Díaz, Julio Enrique
López Lázaro, Miguel
Calderón Montaño, José Manuel
author_role author
author2 Benítez, Guillermo
Pastor Díaz, Julio Enrique
López Lázaro, Miguel
Calderón Montaño, José Manuel
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Biología Vegetal y Ecología
Farmacología
Junta de Andalucía
Universidad de Sevilla
dc.subject.none.fl_str_mv Cancer
Lung cancer
Selectivity
Xiphion xiphium
Iris xiphium
Iridaceae
topic Cancer
Lung cancer
Selectivity
Xiphion xiphium
Iris xiphium
Iridaceae
description Every year, cancer kills millions of people around the world. Finding more selective anticancer agents is essential to improve the low survival rates of patients with metastatic cancers. Since the research of natural products is a valuable approach to the discovery of new compounds and the Iberian flora offers a rich source of unstudied plants, we have carried out a random screening of 76 plant species from 43 families collected in Andalusia (South of Spain). Using non-malignant cells (HaCaT) and lung cancer cells (A549), we found that the extract from Arum italicum Mill. subsp. italicum (Araceae), Mandragora autumnalis Bertol. (Solanaceae), Rhamnus alaternus L. (Rhamnaceae), and Lomelosia simplex (Desf.) Raf. subsp. dentata (Jord. & Fourr.) Greuter & Burdet (Dipsacaceae) showed selective cytotoxicity against lung cancer cells. Extracts of plant species belonging to the Iridaceae family showed high selective activity against cancer cells, highlighting that the Xiphion xiphium (L.) M.B. Crespo, Mart.-Azorín & Mavrodiev flower extract was more selective against lung cancer cells than the standard anticancer drugs, cisplatin and 5-fluorouracil. This extract also showed modest selective cytotoxicity against bladder carcinoma cells (T24). The number of cells in the G1 phase increased after treatment with the extract from Xiphion xiphium. Our research indicates that various plants are potential sources for the isolation and development of new anticancer drugs.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/161808
https://doi.org/10.3390/plants12183275
url https://hdl.handle.net/11441/161808
https://doi.org/10.3390/plants12183275
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Plants, 12 (18), 3275.
2017/CTS-657
2019/CTS-657
2021/CTS-657
VIPPIT-2019-I.5
VIPPIT-2020-I.5
VIPPIT-2021-I
https://doi.org/10.3390/plants12183275
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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