Relationship between corneal morphogeometrical properties and biomechanical parameters derived from dynamic bidirectional air applanation measurement procedure in keratoconus

The morphogeometric analysis of the corneal structure has become a clinically relevant diagnostic procedure in keratoconus (KC) as well as the in vivo evaluation of the corneal biomechanical properties. However, the relationship between these two types of metrics is still not well understood. The cu...

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Autores: Cavas Martínez, Francisco, Piñero Llorens, David Pablo, Velázquez Blázquez, José Sebastián, Mira Pérez, Jorge, Alió Sanz, Jorge Luciano
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad Politécnica de Cartagena(UPCT)
Repositorio:Repositorio Digital UPCT
OAI Identifier:oai:repositorio.upct.es:10317/9330
Acceso en línea:http://hdl.handle.net/10317/9330
https://www.mdpi.com/2075-4418/10/9/640
Access Level:acceso abierto
Palabra clave:Keratoconus
Corneal hysteresis
Corneal biomechanics
Corneal volume
Corneal morphogeometry
Expresión Gráfica en Ingeniería
3201.09 Oftalmología
1203.09 Diseño Con Ayuda del Ordenador
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spelling Relationship between corneal morphogeometrical properties and biomechanical parameters derived from dynamic bidirectional air applanation measurement procedure in keratoconusCavas Martínez, FranciscoPiñero Llorens, David PabloVelázquez Blázquez, José SebastiánMira Pérez, JorgeAlió Sanz, Jorge LucianoKeratoconusCorneal hysteresisCorneal biomechanicsCorneal volumeCorneal morphogeometryExpresión Gráfica en Ingeniería3201.09 Oftalmología1203.09 Diseño Con Ayuda del OrdenadorThe morphogeometric analysis of the corneal structure has become a clinically relevant diagnostic procedure in keratoconus (KC) as well as the in vivo evaluation of the corneal biomechanical properties. However, the relationship between these two types of metrics is still not well understood. The current study investigated the relationship of corneal morphogeometry and volume with two biomechanical parameters: corneal hysteresis (CH) and corneal resistance factor (CRF), both provided by an Ocular Response Analyzer (Reichert). It included 109 eyes from 109 patients (aged between 18 and 69 years) with a diagnosis of keratoconus (KC) who underwent a complete eye examination including a comprehensive corneal topographic analysis with the Sirius system (CSO). With the topographic information obtained, a morphogeometric and volumetric analysis was performed, defining di_erent variables of clinical use. CH and CRF were found to be correlated with these variables, but this correlation was highly influenced by corneal thickness. This suggests that the mechanical properties of KC cornea contribute only in a partial and limited manner to these biomechanical parameters, being mostly influenced by morphogeometry under normal intraocular pressure levels. This would explain the limitation of CH and CRF as diagnostic tools for the detection of incipient cases of KC.This publication was carried out in the framework of the Thematic Network for Co-Operative Research in Health (RETICS) reference number RD12/0034/0007 and RD16/0008/0012, financed by the Carlos III Health Institute—General Subdirection of Networks and Cooperative Investigation Centers (R&D&I National Plan 2008–2011) and the European Regional Development Fund (FEDER). The author David P. Piñero has been supported by the Ministry of Economy, Industry, and Competitiveness of Spain within the program Ramón y Cajal, RYC-2016-20471.MDPIInstituto de Salud Carlos IIIFondo Europeo de Desarrollo Regional (FEDER)202120212020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10317/9330https://www.mdpi.com/2075-4418/10/9/640reponame:Repositorio Digital UPCTinstname:Universidad Politécnica de Cartagena(UPCT)InglésAtribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:repositorio.upct.es:10317/93302026-05-15T06:39:02Z
dc.title.none.fl_str_mv Relationship between corneal morphogeometrical properties and biomechanical parameters derived from dynamic bidirectional air applanation measurement procedure in keratoconus
title Relationship between corneal morphogeometrical properties and biomechanical parameters derived from dynamic bidirectional air applanation measurement procedure in keratoconus
spellingShingle Relationship between corneal morphogeometrical properties and biomechanical parameters derived from dynamic bidirectional air applanation measurement procedure in keratoconus
Cavas Martínez, Francisco
Keratoconus
Corneal hysteresis
Corneal biomechanics
Corneal volume
Corneal morphogeometry
Expresión Gráfica en Ingeniería
3201.09 Oftalmología
1203.09 Diseño Con Ayuda del Ordenador
title_short Relationship between corneal morphogeometrical properties and biomechanical parameters derived from dynamic bidirectional air applanation measurement procedure in keratoconus
title_full Relationship between corneal morphogeometrical properties and biomechanical parameters derived from dynamic bidirectional air applanation measurement procedure in keratoconus
title_fullStr Relationship between corneal morphogeometrical properties and biomechanical parameters derived from dynamic bidirectional air applanation measurement procedure in keratoconus
title_full_unstemmed Relationship between corneal morphogeometrical properties and biomechanical parameters derived from dynamic bidirectional air applanation measurement procedure in keratoconus
title_sort Relationship between corneal morphogeometrical properties and biomechanical parameters derived from dynamic bidirectional air applanation measurement procedure in keratoconus
dc.creator.none.fl_str_mv Cavas Martínez, Francisco
Piñero Llorens, David Pablo
Velázquez Blázquez, José Sebastián
Mira Pérez, Jorge
Alió Sanz, Jorge Luciano
author Cavas Martínez, Francisco
author_facet Cavas Martínez, Francisco
Piñero Llorens, David Pablo
Velázquez Blázquez, José Sebastián
Mira Pérez, Jorge
Alió Sanz, Jorge Luciano
author_role author
author2 Piñero Llorens, David Pablo
Velázquez Blázquez, José Sebastián
Mira Pérez, Jorge
Alió Sanz, Jorge Luciano
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Fondo Europeo de Desarrollo Regional (FEDER)
dc.subject.none.fl_str_mv Keratoconus
Corneal hysteresis
Corneal biomechanics
Corneal volume
Corneal morphogeometry
Expresión Gráfica en Ingeniería
3201.09 Oftalmología
1203.09 Diseño Con Ayuda del Ordenador
topic Keratoconus
Corneal hysteresis
Corneal biomechanics
Corneal volume
Corneal morphogeometry
Expresión Gráfica en Ingeniería
3201.09 Oftalmología
1203.09 Diseño Con Ayuda del Ordenador
description The morphogeometric analysis of the corneal structure has become a clinically relevant diagnostic procedure in keratoconus (KC) as well as the in vivo evaluation of the corneal biomechanical properties. However, the relationship between these two types of metrics is still not well understood. The current study investigated the relationship of corneal morphogeometry and volume with two biomechanical parameters: corneal hysteresis (CH) and corneal resistance factor (CRF), both provided by an Ocular Response Analyzer (Reichert). It included 109 eyes from 109 patients (aged between 18 and 69 years) with a diagnosis of keratoconus (KC) who underwent a complete eye examination including a comprehensive corneal topographic analysis with the Sirius system (CSO). With the topographic information obtained, a morphogeometric and volumetric analysis was performed, defining di_erent variables of clinical use. CH and CRF were found to be correlated with these variables, but this correlation was highly influenced by corneal thickness. This suggests that the mechanical properties of KC cornea contribute only in a partial and limited manner to these biomechanical parameters, being mostly influenced by morphogeometry under normal intraocular pressure levels. This would explain the limitation of CH and CRF as diagnostic tools for the detection of incipient cases of KC.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10317/9330
https://www.mdpi.com/2075-4418/10/9/640
url http://hdl.handle.net/10317/9330
https://www.mdpi.com/2075-4418/10/9/640
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositorio Digital UPCT
instname:Universidad Politécnica de Cartagena(UPCT)
instname_str Universidad Politécnica de Cartagena(UPCT)
reponame_str Repositorio Digital UPCT
collection Repositorio Digital UPCT
repository.name.fl_str_mv
repository.mail.fl_str_mv
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