Benchmarking of survival outcomes following Haematopoietic Stem Cell Transplantation (HSCT)

From 2016 EBMT and JACIE developed an international risk-adapted benchmarking program of haematopoietic stem cell transplant (HSCT) outcome to provide individual EBMT Centers with a means of quality-assuring the HSCT process and meeting FACT-JACIE accreditation requirements relating to 1-year surviv...

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Autores: Saccardi, Riccardo|||0000-0002-5763-5467, Putter, Hein|||0000-0001-5395-1422, Eikema, Dirk-Jan, Busto, María Paula, McGrath, Eoin|||0000-0002-1956-037X, Middelkoop, Bas, Adams, Gillian, Atlija, Marina, Ayuk, Francis, Baldomero, Helen|||0000-0002-6554-483X, Beguin, Yves|||0000-0003-4650-7520, de la Camara, Rafael|||0000-0002-8189-5779, Cedillo Cedillo, Angel|||0000-0002-0126-7044, Sureda, Anna|||0000-0002-1238-6970, Chabannon, Christian|||0000-0002-3755-4889, Corbacioglu, Selim|||0000-0003-1070-8486, Dolstra, Harry, Duarte, Rafael|||0000-0002-5240-9815, Duléry, Rémy|||0000-0002-5024-1713, Greco, Raffaella|||0000-0002-6117-5328, Gusi, Andreu, Hamad, Nada|||0000-0001-7929-1450, Kenyon, Michelle|||0000-0002-1859-6178, Kroeger, Nicolaus|||0000-0001-5103-9966, Labopin, Myriam|||0000-0003-4514-4748, Lee, Julia, Ljungman, Per|||0000-0002-8281-3245, Manson, Lynn, Mensil, Florence, Milpied, Noel|||0000-0002-5177-014X, Mohty, Mohamad|||0000-0002-7264-808X, Oldani, Elena, Orchard, Kim|||0000-0003-2276-3925, Passweg, Jakob, Pearce, Rachel, de Latour, Régis Peffault, Poirel, Hélène A.|||0000-0002-0712-5127, Rintala, Tuula, Rizzo, J. Douglas|||0000-0003-1474-1152, Ruggeri, Annalisa|||0000-0002-7261-2765, Sanchez-Martinez, Carla, Sánchez Guijo, Fermín|||0000-0002-7076-7739, Sánchez-Ortega, Isabel, Trnková, Marie, Valcárcel, David|||0000-0002-8747-078X, Wilcox, Leonie, de Wreede, Liesbeth C.|||0000-0002-7667-9369, Snowden, John A.|||0000-0001-6819-3476
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:279339
Acceso en línea:https://ddd.uab.cat/record/279339
https://dx.doi.org/urn:doi:10.1038/s41409-023-01924-6
Access Level:acceso abierto
Palabra clave:Haematological cancer
Therapeutics
Descripción
Sumario:From 2016 EBMT and JACIE developed an international risk-adapted benchmarking program of haematopoietic stem cell transplant (HSCT) outcome to provide individual EBMT Centers with a means of quality-assuring the HSCT process and meeting FACT-JACIE accreditation requirements relating to 1-year survival outcomes. Informed by previous experience from Europe, North America and Australasia, the Clinical Outcomes Group (COG) established criteria for patient and Center selection, and a set of key clinical variables within a dedicated statistical model adapted to the capabilities of the EBMT Registry. The first phase of the project was launched in 2019 to test the acceptability of the benchmarking model through assessment of Centers' performance for 1-year data completeness and survival outcomes of autologous and allogeneic HSCT covering 2013-2016. A second phase was delivered in July 2021 covering 2015-2019 and including survival outcomes. Reports of individual Center performance were shared directly with local principal investigators and their responses were assimilated. The experience thus far has supported the feasibility, acceptability and reliability of the system as well as identifying its limitations. We provide a summary of experience and learning so far in this 'work in progress', as well as highlighting future challenges of delivering a modern, robust, data-complete, risk-adapted benchmarking program across new EBMT Registry systems.

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