Malignancies among children and young people with HIV in Western and Eastern Europe and Thailand

Objectives: Investigate trends over time and predictors of malignancies among children and young people with HIV. Design: Pooled data from 17 cohorts in 15 countries across Europe and Thailand. Methods: Individuals diagnosed with HIV and presenting to paediatric care less than 18 years of age were i...

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Autores: Chappell, Elizabeth, Turkova, Anna, Goetghebuer, Tessa, Jackson, Charlotte, Chiappini, Elena, Galli, Luisa, Gingaras, Cosmina, Judd, Ali, Spoulou, Vana, Lisi, Catiuscia, Ansone, Santa, Wolfs, Tom, Marczynska, Magdalena, Ene, Luminita, Plotnikova, Yulia, Voronin, Evgeny, Samarina, Anna, Jourdain, Gonzague, Ngo-Giang-Huong, Nicole, Fortuny, Claudia, Luisa Navarro, Marisa, Tomas Ramos, Jose, Naver, Lars, Crisinel, Pierre-Alex, Bailey, Heather, Malyuta, Ruslan, Volokha, Alla, Crichton, Siobhan, Foster, Caroline, Thorne, Claire, Collins, Intira Jeannie, Giaquinto, Carlo, Gibb, Diana M., Critchton, Siobhan, Duff, Charlotte, Goodall, Ruth, Gomezpena, Daniel, Lundin, Rebecca, Mangiarini, Laura, Milanzi, Edith, Nardone, Alessandra, Hainaut, Marc, Van der Kelen, Evelyne, Delforge, Marc, de Martino, Maurizio, Tovo, Pier Angelo, Gabiano, Clara, Carloni, Ines, Larovere, Domenico, Baldi, Francesco, Miniaci, Angela, Pession, andrea, Badolato, Raffaele, Panto, Grazia, Anastasio, Elisa, Montagnani, Carlotta, Venturini, Elisabetta, Bianchi, Leila, Allodi, Alessandra, Di Biagio, Antonio, Grignolo, Sara, Giacomet, Vania, Marchisio, Paola, Banderali, Giuseppe, Tagliabue, Claudia, Cellini, Monica, Bruzzese, Eugenia, Di Costanzo, Pasquale, Lo Vecchio, andrea, Dona, Daniele, Rampon, Osvalda, Romano, Amelia, Dodi, Icilio, Esposito, Susanna, Zuccaro, Valentina, Zanaboni, Domenico, Consolini, Rita, Bernardi, Stefania, Genovese, Orazio, Cristiano, Letizia, Mazza, Antonio, Garazzino, Silvia, Mignone, Federica, Silvestro, Erika, Portelli, Vincenzo, Pajkrt, D., Scherpbier, H. J., Weijsenfeld, A. M., de Boer, C. G., Jurriaans, S., Back, N. K. T., Zaaijer, H. L., Berkhout, B., Cornelissen, M. T. E., Schinkel, C. J., Wolthers, K. C., Fraaij, P. L. A., van Rossum, A. M. C., Vermont, C. L., van der Knaap, L. C., Visser, E. G., Boucher, C. A. B., Koopmans, M. P. G., van Kampen, J. J. A., Pas, S. D., Henriet, S. S. V., van de Flier, M., van Aerde, K., Strik-Albers, R., Rahamat-Langendoen, J., Stelma, F. F., Scholvinck, E. H., de Groot-de Jonge, H., Niesters, H. G. M., van Leer-Buter, C. C., Knoester, M., Bont, L. J., Geelen, S. P. M., Wolfs, T. F. W., Nauta, N., Schuurman, R., Verduyn-Lunel, F., Wensing, A. M. J., Reiss, Peter, Zaheri, S., Bezemer, D. O., van Sighem, Ard, Smit, Colette, Wit, F. W. M. N., Hillebregt, M., de Jong, A., Woudstra, T., Bergsma, D., Grivell, S., Meijering, R., Raethke, M., Rutkens, T., de Groot, L., van den Akker, M., Bakker, Y., Bezemer, M., El Berkaoui, A., Geerlinks, J., Koops, J., Kruijne, E., Lodewijk, C., Lucas, E., van der Meer, R., Munjishvili, L., Paling, F., Peeck, B., Ree, C., Regtop, R., Ruijs, Y., van de Sande, L., Schoorl, M., Schnorr, P., Tuijn, E., Veenenberg, L., van der Vliet, S., Wisse, A., Witte, E. C., Tuk, B., Popielska, Jolanta, Pokorska-Spiewak, Maria, Oldakowska, Agnieszka, Zawadka, Konrad, Coupland, Urszula, Doroba, Malgorzata, Okhonskaia, Liubov, Miloenko, Milana, Labutina, Svetlana, Soler-Palacin, Pere, Antoinette Frick, Maria, Perez-Hoyos, Santiago, Mur, Antonio, Lopez, Nuria, Mendez, Maria, Mayol, Lluis, Vallmanya, Teresa, Calavia Garsaball, Olga, Garcia, Lourdes, Coll, María Teresa, Pineda, Valenti, Rius, Neus, Rovira, Nuria, Dueñas Morales, Joaquin, Noguera-Julian, Antoni, Jose Mellado, Maria, Escosa, Luis, Garcia Hortelano, Milagros, Sainz, Talia, Isabel Gonzalez-Tome, Maria, Rojo, Pablo, Blazquez, Daniel, Prieto, Luis, Guillen, Sara, Luisa Navarro, Maria, Saavedra, Jesus, Santos, Mar, Angeles Munoz, Ma, Ruiz, Beatriz, Fernandez Mc Phee, Carolina, Jimenez de Ory, Santiago, Alvarez, Susana, Angel Roa, Miguel, Beceiro, Jose, Martinez, Jorge, Badillo, Katie, Apilanez, Miren, Pocheville, Itziar, Garrote, Elisa, Colino, Elena, Gomez Sirvent, Jorge, Garzon, Monica, Roman, Vicente, Montesdeoca, Abian, Mateo, Mercedes, Jose Munoz, Maria, Angulo, Raquel, Neth, Olaf, Falcon, Lola, Terol, Pedro, Luis Santos, Juan, Moreno, David, Lendinez, Francisco, Grande, Ana, Jose Romero, Francisco, Perez, Carlos, Lillo, Miguel, Losada, Begona, Herranz, Mercedes, Bustillo, Matilde, Guerrero, Carmelo, Collado, Pilar, Couceiro, Jose Antonio, Perez, Amparo, Piqueras, Ana Isabel, Breton, Rafael, Segarra, Inmaculada, Gavilan, Cesar, Jareno, Enrique, Montesinos, Elena, Dapena Archiles, Marta, Álvarez Segurado, Cristina, Gloria Andres, Ana, Marugan, Victor, Ochoa, Carlos, Alfayate, Santiago, Menasalvas, Ana Isabel, de Miguel, Elisa, Soeria-Atmadja, Sandra, Belfrage, Erik, Hagas, Vendela, Aebi-Popp, K., Anagnostopoulos, A., Asner, S., Battegay, Manuel, Baumann, M., Bernasconi, E., Boni, J., Braun, D. 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A., Yerly, S., Wannarit, Pornpun, Techakunakorn, Pornchai, Hansudewechakul, Rawiwan, Kham, Chiang, Wanchaitanawong, Vanichaya, Theansavettrakul, Sookchai, Sai, Mae, Nanta, Sirisak, Ngampiyaskul, Chaiwat, Phanomcheong, Siriluk, Hongsiriwon, Suchat, Karnchanamayul, Warit, Chacheongsao, Bhuddasothorn, Kwanchaipanich, Ratchanee, Kanjanavanit, Suparat, Prapinklao, Somdej, Kamonpakorn, Nareerat, Nantarukchaikul, Maneeratn, Adulyadej, Bhumibol, Layangool, Prapaisri, Mekmullica, Jutarat, Lucksanapisitkul, Paiboon, Watanayothin, Sudarat, Lertpienthum, Narong, Yai, Hat, Warachit, Boonyarat, Kaen, Khon, Hanpinitsak, Sansanee, Khai, Nong, Potchalongsin, Sathit, Thanasiri, Pimpraphai, Krikajornkitti, Sawitree, Attavinijtrakarn, Pornsawan, Srirojana, Sakulrat, Bunjongpak, Suthunya, Puangsombat, Achara, Na-Rajsima, Sathaporn, Ananpatharachai, Pornchai, Akarathum, Noppadon, Phuket, Vachira, Lawtongkum, Weerasak, Kheunjan, Prapawan, Suriyaboon, Thitiporn, Saipanya, Airada, Than-In-At, Kanchana, Jaisieng, Nirattiya, Suaysod, Rapeepan, Chailoet, Sanuphong, Naratee, Naritsara, Kawilapat, Suttipong, Kaleeva, T., Baryshnikova, Y., Soloha, S., Bashkatova, N., Raus, I., Glutshenko, O., Ruban, Z., Prymak, N., Kiseleva, G., Lyall, Hermione, Bamford, Alasdair, Butler, Karina, Doerholt, Katja, Doherty, Conor, Harrison, Ian, Kenny, Julia, Klein, Nigel, Letting, Gillian, McMaster, Paddy, Murau, Fungai, Nsangi, Edith, Prime, Katia, Riordan, Andrew, Shackley, Fiona, Shingadia, Delane, Storey, Sharon, Tudor-Williams, Gareth, Welch, Steve, Cook, Claire, Dobson, Donna, Fairbrother, Keith, Le Prevost, Marthe, Van Looy, Nadine, Peters, Helen, Francis, Kate, Thrasyvoulou, L., Welch, S., Fidler, Katy J., Bernatoniene, J., Manyika, F., Sharpe, G., Subramaniam, B., Hague, R., Price, V., Flynn, J., Cardoso, A., Abou-Rayyah, M., Klein, N., Yeadon, S., Segal, S., Hawkins, S., Dowie, M., Bandi, S., Percival, E., Eisenhut, M., Duncan, K., Anguvaa, L., Wren, L., Flood, T., Pickering, A., McMaster, P., Murphy, C., Daniels, J., Lees, Y., Thompson, F., Williams, A., Williams, B., Pope, S., Libeschutz, S., Cliffe, L., Southall, S., Freeman, Alexandra F., Freeman, H., Christie, S., Gordon, A., Hague, D. Rosie, Clarke, L., Jones, L., Brown, L., Greenberg, M., Benson, C., Ibberson, L., Shackley, F., Patel, S., Hancock, J., Prime, K., Sharland, M., Lyall, E. G. H., Seery, P., Kirkhope, N., Raghunanan, S., Callaghan, A., Bridgwood, A., Evans, Jonathan P., Blake, E., Yannoulias, A., European Pregnancy & Paediat
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/19678
Acceso en línea:https://hdl.handle.net/20.500.13003/19678
Access Level:acceso abierto
Palabra clave:Child
Aged
Adult
Acquired Immunodeficiency Syndrome
Humans
Adolescent
Neoplasms
HIV Infections
Male
Infant, Newborn
Europe
Europe, Eastern
Thailand
Tailandia
Recién Nacido
Infecciones por VIH
Europa Oriental
Europa (Continente)
Adolescente
Masculino
Síndrome de Inmunodeficiencia Adquirida
Humanos
Neoplasias
Anciano
Niño
Adulto
adolescents
children
HIV
malignancies
Descripción
Sumario:Objectives: Investigate trends over time and predictors of malignancies among children and young people with HIV. Design: Pooled data from 17 cohorts in 15 countries across Europe and Thailand. Methods: Individuals diagnosed with HIV and presenting to paediatric care less than 18 years of age were included. Time at risk began at birth for children with documented vertically acquired HIV, and from first HIV-care visit for others. Children were followed until death, loss-to-follow-up, or last visit in paediatric or adult care (where data after transfer to adult care were available). Rates of reported malignancies were calculated overall and for AIDS-defining malignancies (ADM) and non-AIDS-defining malignancies (NADM) separately. Risk factors for any malignancy were explored using Poisson regression, and for mortality following a malignancy diagnosis using Cox regression. Results: Among 9632 individuals included, 140 (1.5%) were ever diagnosed with a malignancy, of which 112 (80%) were ADM. Overall, the rate of any malignancy was 1.18 per 1000 person-years; the rate of ADM decreased over time whereas the rate of NADM increased. Male sex, being from a European cohort, vertically acquired HIV, current severe immunosuppression, current viral load greater than 400 copies/ml, older age, and, for those not on treatment, earlier calendar year, were risk factors for a malignancy diagnosis. Fifty-eight (41%) individuals with a malignancy died, a median 2.4 months (IQR 0.6-8.8) after malignancy diagnosis. Conclusion: The rate of ADM has declined since widespread availability of combination ART, although of NADM, there was a small increase. Mortality following a malignancy was high, warranting further investigation.