Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohort

<p><span style="color:rgb( 46 , 46 , 46 )">Background and aims: Atherosclerosis is the major risk factor for cardiovascular disease (CVD), the first cause of death worldwide. Chronic low-grade inflammation and a sustained oxidative milieu are causatively related to atherosclero...

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Autores: Bujosa, Francesc, Herreras, Zoe, Catalán, Marta, Pinyol, Montserrat, Lamuela Raventós, Rosa Ma., Martínez Huélamo, Miriam, Gilabert, Rosa, Jiménez Pineda, Amanda, Ortega Martínez de Victoria, Emilio, Chiva Blanch, Gemma
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/208204
Acceso en línea:https://hdl.handle.net/2445/208204
Access Level:acceso abierto
Palabra clave:Aterosclerosi
Cuina mediterrània
Atherosclerosis
Mediterranean cooking
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spelling Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohortBujosa, FrancescHerreras, ZoeCatalán, MartaPinyol, MontserratLamuela Raventós, Rosa Ma.Martínez Huélamo, MiriamGilabert, RosaJiménez Pineda, AmandaOrtega Martínez de Victoria, EmilioChiva Blanch, GemmaAterosclerosiCuina mediterràniaAtherosclerosisMediterranean cooking<p><span style="color:rgb( 46 , 46 , 46 )">Background and aims: Atherosclerosis is the major risk factor for cardiovascular disease (CVD), the first cause of death worldwide. Chronic low-grade inflammation and a sustained oxidative milieu are causatively related to atherosclerosis onset and progression, and therefore, dietary patterns rich in bioactive compounds with anti-inflammatory and antioxidant activities might likely contribute to revert or slowing the progression of atherosclerosis. The aim of this study is to analyse the association between fruit and vegetables intake, quantitatively measured through carotene plasma concentrations, and atherosclerotic burden, as a surrogate biomarker of CVD, in free-living subjects from the DIABIMCAP cohort study. Methods: The 204 participants of the DIABIMCAP Study cohort (Carotid Atherosclerosis in Newly Diagnosed Type 2 Diabetic Individuals, ClinicalTrials.gov Identifier: NCT01898572), were included in this cross-sectional study. Total, α-, and β-carotenes were quantified by HPLC-MS/MS. Lipoprotein analysis in serum was performed by 2D- 1H NMR- DOSY, and atherosclerosis and intima media thickness (IMT) were measured through standardized bilateral carotid artery ultrasound imaging. Results: Subjects with atherosclerosis (n = 134) had lower levels of large HDL particles than subjects without atherosclerosis. Positive associations were found between α-carotene and both large and medium HDL particles, and inverse associations were found between β- and total carotene, and VLDL and its medium/small particles. Subjects with atherosclerosis presented significantly lower plasma concentrations of total carotene compared with subjects without atherosclerosis. Plasma concentrations of carotene decreased as the number of atherosclerotic plaques increased, although after multivariate adjustment, the inverse association between β- and total carotene with plaque burden remained significant only in women. Conclusions: A diet rich in fruit and vegetables results in higher plasmatic carotene concentrations, which are associated with a lesser atherosclerotic plaque burden. © 2023 The Author(s)</span></p>Elsevier2024202420232024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion7 p.application/pdfhttps://hdl.handle.net/2445/208204Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.clnu.2023.05.005Clinical Nutrition, 2023, vol. 42, num.7, p. 1168-1174https://doi.org/10.1016/j.clnu.2023.05.005cc-by-nc-nd (c) Francesc Bujosa, et al., 2023http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2082042026-05-29T05:05:01Z
dc.title.none.fl_str_mv Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohort
title Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohort
spellingShingle Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohort
Bujosa, Francesc
Aterosclerosi
Cuina mediterrània
Atherosclerosis
Mediterranean cooking
title_short Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohort
title_full Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohort
title_fullStr Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohort
title_full_unstemmed Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohort
title_sort Total carotene plasma concentrations are inversely associated with atherosclerotic plaque burden: A post-hoc analysis of the DIABIMCAP cohort
dc.creator.none.fl_str_mv Bujosa, Francesc
Herreras, Zoe
Catalán, Marta
Pinyol, Montserrat
Lamuela Raventós, Rosa Ma.
Martínez Huélamo, Miriam
Gilabert, Rosa
Jiménez Pineda, Amanda
Ortega Martínez de Victoria, Emilio
Chiva Blanch, Gemma
author Bujosa, Francesc
author_facet Bujosa, Francesc
Herreras, Zoe
Catalán, Marta
Pinyol, Montserrat
Lamuela Raventós, Rosa Ma.
Martínez Huélamo, Miriam
Gilabert, Rosa
Jiménez Pineda, Amanda
Ortega Martínez de Victoria, Emilio
Chiva Blanch, Gemma
author_role author
author2 Herreras, Zoe
Catalán, Marta
Pinyol, Montserrat
Lamuela Raventós, Rosa Ma.
Martínez Huélamo, Miriam
Gilabert, Rosa
Jiménez Pineda, Amanda
Ortega Martínez de Victoria, Emilio
Chiva Blanch, Gemma
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Aterosclerosi
Cuina mediterrània
Atherosclerosis
Mediterranean cooking
topic Aterosclerosi
Cuina mediterrània
Atherosclerosis
Mediterranean cooking
description <p><span style="color:rgb( 46 , 46 , 46 )">Background and aims: Atherosclerosis is the major risk factor for cardiovascular disease (CVD), the first cause of death worldwide. Chronic low-grade inflammation and a sustained oxidative milieu are causatively related to atherosclerosis onset and progression, and therefore, dietary patterns rich in bioactive compounds with anti-inflammatory and antioxidant activities might likely contribute to revert or slowing the progression of atherosclerosis. The aim of this study is to analyse the association between fruit and vegetables intake, quantitatively measured through carotene plasma concentrations, and atherosclerotic burden, as a surrogate biomarker of CVD, in free-living subjects from the DIABIMCAP cohort study. Methods: The 204 participants of the DIABIMCAP Study cohort (Carotid Atherosclerosis in Newly Diagnosed Type 2 Diabetic Individuals, ClinicalTrials.gov Identifier: NCT01898572), were included in this cross-sectional study. Total, α-, and β-carotenes were quantified by HPLC-MS/MS. Lipoprotein analysis in serum was performed by 2D- 1H NMR- DOSY, and atherosclerosis and intima media thickness (IMT) were measured through standardized bilateral carotid artery ultrasound imaging. Results: Subjects with atherosclerosis (n = 134) had lower levels of large HDL particles than subjects without atherosclerosis. Positive associations were found between α-carotene and both large and medium HDL particles, and inverse associations were found between β- and total carotene, and VLDL and its medium/small particles. Subjects with atherosclerosis presented significantly lower plasma concentrations of total carotene compared with subjects without atherosclerosis. Plasma concentrations of carotene decreased as the number of atherosclerotic plaques increased, although after multivariate adjustment, the inverse association between β- and total carotene with plaque burden remained significant only in women. Conclusions: A diet rich in fruit and vegetables results in higher plasmatic carotene concentrations, which are associated with a lesser atherosclerotic plaque burden. © 2023 The Author(s)</span></p>
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/208204
url https://hdl.handle.net/2445/208204
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.clnu.2023.05.005
Clinical Nutrition, 2023, vol. 42, num.7, p. 1168-1174
https://doi.org/10.1016/j.clnu.2023.05.005
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Francesc Bujosa, et al., 2023
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Francesc Bujosa, et al., 2023
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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