Gibeleko erradioenbolizazioaren CFD simulazioak: odolaren biskositatearen eragina gibeleko hemodinamikan eta mikroesferen banaketan

Radioembolization (RE) is a treatment for patients with liver cancer. RE consists of the infusion of radioactive microspheres in the hepatic artery using a microcatheter. Microspheres treat tumors by embolization and radiation. The trajectory of the microspheres can be analyzed using computational f...

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Bibliographic Details
Authors: Lertxundi, Unai, Aramburu Montenegro, Jorge, Antón Remírez, Raúl, Bilbao Jaureguizar, José Ignacio, Rodríguez Fraile, M., Sangro Gómez Acebo, Bruno
Format: article
Publication Date:2022
Country:España
Institution:Universidad del País Vasco
Repository:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/57544
Online Access:http://hdl.handle.net/10810/57544
Access Level:Open access
Description
Summary:Radioembolization (RE) is a treatment for patients with liver cancer. RE consists of the infusion of radioactive microspheres in the hepatic artery using a microcatheter. Microspheres treat tumors by embolization and radiation. The trajectory of the microspheres can be analyzed using computational fluid dynamics simulations (CFD). The long duration of these calculations supposes a problem for their use in the clinical setting. To decrease the simulation time, blood, a non-Newtonian fluid, was considered as a Newtonian fluid. Results show that microsphere distribution and blood flow characteristics barely change when using a Newtonian fluid approach vs. a non-Newtonian fluid approach.; Erradioenbolizazioa (RE) gibeleko minbizia tratatzeko metodoetako bat da. Bertan, mikrokateter bidez gibeleko arterian mikroesfera erradioaktiboak injektatzen dira, tumoreei enbolizazio eta erradiazio bidez erasotzeko. Mikroesferen ibilbidea ordenagailu bidezko fluido dinamikako simulazioekin (CFD) azter daiteke. kalkulu horien iraupen luzea arazo bat da medikuntzaren egunerokotasunean simulazioak erabili ahal izateko. kalkuluak azkartzeko asmoz, odolaren biskositatearen izaera ez-newtondarra izaera newtondarrera sinplifikatu da. Emaitzek erakutsi dute mikroesferen banaketan eta odolaren hemodinamikan biskositate aldakorraren eragina baztergarria dela, odola fluido newtondar gisa aztertzearen sinplifikazioa ontzat emanez.