Comparison of the amyloid plaque proteome in Down syndrome, early-onset Alzheimer's disease, and late-onset Alzheimer's disease

Down syndrome (DS) is strongly associated with Alzheimer's disease (AD) due to APP overexpression, exhibiting Amyloid-β (Aβ) and Tau pathology similar to early-onset (EOAD) and late-onset AD (LOAD). We evaluated the Aβ plaque proteome of DS, EOAD, and LOAD using unbiased localized proteomics on...

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Detalles Bibliográficos
Autores: Martá-Ariza, M., Leitner, D.F., Kanshin, E., Suazo, J., Giusti Pedrosa, A., Thierry, M., Lee, E.B., Devinsky, O., Drummond, E., Fortea, Juan|||0000-0002-1340-638X, Lleó, Alberto|||0000-0002-2568-5478, Ueberheide, B., Wisniewski, Thomas M.
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:320386
Acceso en línea:https://ddd.uab.cat/record/320386
https://dx.doi.org/urn:doi:10.1007/s00401-025-02844-z
Access Level:acceso abierto
Palabra clave:Alzheimer's disease
Amyloid-β
Down syndrome
Neuropathology
Proteomics
Descripción
Sumario:Down syndrome (DS) is strongly associated with Alzheimer's disease (AD) due to APP overexpression, exhibiting Amyloid-β (Aβ) and Tau pathology similar to early-onset (EOAD) and late-onset AD (LOAD). We evaluated the Aβ plaque proteome of DS, EOAD, and LOAD using unbiased localized proteomics on post-mortem paraffin-embedded tissues from four cohorts (n = 20/group): DS (59.8 ± 4.99 y/o), EOAD (63 ± 4.07 y/o), LOAD (82.1 ± 6.37 y/o), and controls (66.4 ± 13.04). We identified differentially abundant proteins when comparing Aβ plaques and neighboring non-plaque tissue (FDR < 5%, fold-change.

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