5-Lipooxygenase Derivatives as Serum Biomarkers of a Successful Dietary Intervention in Patients with NonAlcoholic Fatty Liver Disease
It was previously shown that a bodyweight reduction among patients with nonalcoholic fatty liver (NAFLD) was connected to the lower concentration of arachidonic and linoleic acid derivatives in their blood. We hypothesized that the concentration of these lipids was correlated with the extent of thei...
| Autores: | , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/65194 |
| Acceso en línea: | https://hdl.handle.net/10171/65194 |
| Access Level: | acceso abierto |
| Palabra clave: | Derivatives Nonalcoholic fatty liver Oxylipids Steatosis |
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5-Lipooxygenase Derivatives as Serum Biomarkers of a Successful Dietary Intervention in Patients with NonAlcoholic Fatty Liver DiseaseBanaszczak, M. (Marcin)|||/items/339a98d4-81c9-4a29-ac84-b23106526156Maciejewska, D. (Dominika)|||/items/9d778eb7-c02d-4392-a1a8-94eca4d2a662Drozd, A. (Arleta)|||/items/1792207f-f306-47c8-ba95-f978e8e26c92Ryterska, K. (Karina)|||/items/e9f82d46-e871-4493-be17-2afe175d6e66Jamiol-Milc, D. (Dominika)|||/items/26a9cd1c-b24f-4127-af78-a6754432ddb7Raszeja-Wyszomirska, J. (Joanna)|||/items/541b341f-083e-4e39-b388-b2624a9221a5Wunsch, E. (Eva)|||/items/febe3385-7cd8-404d-af25-6be3c1c82954Gonzalez-Muniesa, P. (Pedro)|||/items/3c8817f9-abc8-4a50-8bbd-68c967b4df48Stachowska, E. (Ewa)|||/items/0fd8b662-097d-4316-a251-79602d758357DerivativesNonalcoholic fatty liverOxylipidsSteatosisIt was previously shown that a bodyweight reduction among patients with nonalcoholic fatty liver (NAFLD) was connected to the lower concentration of arachidonic and linoleic acid derivatives in their blood. We hypothesized that the concentration of these lipids was correlated with the extent of their body mass reduction and, thus, liver steatosis. Methods: We analyzed 68 individuals who completed the dietary intervention. Patients were divided into two groups depending on their body mass reduction (more or less than 7%). Before and after the dietary intervention, all patients had the following measurements recorded: body mass, waist circumference, stage of steatosis, fatty liver index, liver enzymes, lipid parameters, insulin and glucose. Concentrations of lipoxins A4 (LTX A4), hydroxyeicosatetraenoic fatty acids (5(S)-HETE, 12(S)-HETE and 16(S)-HETE), hydroxyoctadecaenoic acids (9(S)-HODE and 13(S)-HODE) and 5-oxo-eicosatetraenoic acid (5-oxo-ETE) were measured in serum samples collected before and after the dietetic intervention using high-performance liquid chromatography (HPLC). Results: Patients who reduced their body mass by more than 7% revealed a significant improvement in their steatosis stage, waist circumference, fatty liver index, triglycerides and cholesterol. Conclusion: A reduction in body mass by more than 7% but not by less than 7% revealed a significant improvement in steatosis stage; waist circumference; fatty liver index; and levels of triglycerides, cholesterol, 5-oxo-ETE and LTXA-4.MDPIDadun. Depósito Académico Digital Universidad de Navarra20232023-01-3020202020-01-0120202020-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/65194reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/651942026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
5-Lipooxygenase Derivatives as Serum Biomarkers of a Successful Dietary Intervention in Patients with NonAlcoholic Fatty Liver Disease |
| title |
5-Lipooxygenase Derivatives as Serum Biomarkers of a Successful Dietary Intervention in Patients with NonAlcoholic Fatty Liver Disease |
| spellingShingle |
5-Lipooxygenase Derivatives as Serum Biomarkers of a Successful Dietary Intervention in Patients with NonAlcoholic Fatty Liver Disease Banaszczak, M. (Marcin)|||/items/339a98d4-81c9-4a29-ac84-b23106526156 Derivatives Nonalcoholic fatty liver Oxylipids Steatosis |
| title_short |
5-Lipooxygenase Derivatives as Serum Biomarkers of a Successful Dietary Intervention in Patients with NonAlcoholic Fatty Liver Disease |
| title_full |
5-Lipooxygenase Derivatives as Serum Biomarkers of a Successful Dietary Intervention in Patients with NonAlcoholic Fatty Liver Disease |
| title_fullStr |
5-Lipooxygenase Derivatives as Serum Biomarkers of a Successful Dietary Intervention in Patients with NonAlcoholic Fatty Liver Disease |
| title_full_unstemmed |
5-Lipooxygenase Derivatives as Serum Biomarkers of a Successful Dietary Intervention in Patients with NonAlcoholic Fatty Liver Disease |
| title_sort |
5-Lipooxygenase Derivatives as Serum Biomarkers of a Successful Dietary Intervention in Patients with NonAlcoholic Fatty Liver Disease |
| dc.creator.none.fl_str_mv |
Banaszczak, M. (Marcin)|||/items/339a98d4-81c9-4a29-ac84-b23106526156 Maciejewska, D. (Dominika)|||/items/9d778eb7-c02d-4392-a1a8-94eca4d2a662 Drozd, A. (Arleta)|||/items/1792207f-f306-47c8-ba95-f978e8e26c92 Ryterska, K. (Karina)|||/items/e9f82d46-e871-4493-be17-2afe175d6e66 Jamiol-Milc, D. (Dominika)|||/items/26a9cd1c-b24f-4127-af78-a6754432ddb7 Raszeja-Wyszomirska, J. (Joanna)|||/items/541b341f-083e-4e39-b388-b2624a9221a5 Wunsch, E. (Eva)|||/items/febe3385-7cd8-404d-af25-6be3c1c82954 Gonzalez-Muniesa, P. (Pedro)|||/items/3c8817f9-abc8-4a50-8bbd-68c967b4df48 Stachowska, E. (Ewa)|||/items/0fd8b662-097d-4316-a251-79602d758357 |
| author |
Banaszczak, M. (Marcin)|||/items/339a98d4-81c9-4a29-ac84-b23106526156 |
| author_facet |
Banaszczak, M. (Marcin)|||/items/339a98d4-81c9-4a29-ac84-b23106526156 Maciejewska, D. (Dominika)|||/items/9d778eb7-c02d-4392-a1a8-94eca4d2a662 Drozd, A. (Arleta)|||/items/1792207f-f306-47c8-ba95-f978e8e26c92 Ryterska, K. (Karina)|||/items/e9f82d46-e871-4493-be17-2afe175d6e66 Jamiol-Milc, D. (Dominika)|||/items/26a9cd1c-b24f-4127-af78-a6754432ddb7 Raszeja-Wyszomirska, J. (Joanna)|||/items/541b341f-083e-4e39-b388-b2624a9221a5 Wunsch, E. (Eva)|||/items/febe3385-7cd8-404d-af25-6be3c1c82954 Gonzalez-Muniesa, P. (Pedro)|||/items/3c8817f9-abc8-4a50-8bbd-68c967b4df48 Stachowska, E. (Ewa)|||/items/0fd8b662-097d-4316-a251-79602d758357 |
| author_role |
author |
| author2 |
Maciejewska, D. (Dominika)|||/items/9d778eb7-c02d-4392-a1a8-94eca4d2a662 Drozd, A. (Arleta)|||/items/1792207f-f306-47c8-ba95-f978e8e26c92 Ryterska, K. (Karina)|||/items/e9f82d46-e871-4493-be17-2afe175d6e66 Jamiol-Milc, D. (Dominika)|||/items/26a9cd1c-b24f-4127-af78-a6754432ddb7 Raszeja-Wyszomirska, J. (Joanna)|||/items/541b341f-083e-4e39-b388-b2624a9221a5 Wunsch, E. (Eva)|||/items/febe3385-7cd8-404d-af25-6be3c1c82954 Gonzalez-Muniesa, P. (Pedro)|||/items/3c8817f9-abc8-4a50-8bbd-68c967b4df48 Stachowska, E. (Ewa)|||/items/0fd8b662-097d-4316-a251-79602d758357 |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Derivatives Nonalcoholic fatty liver Oxylipids Steatosis |
| topic |
Derivatives Nonalcoholic fatty liver Oxylipids Steatosis |
| description |
It was previously shown that a bodyweight reduction among patients with nonalcoholic fatty liver (NAFLD) was connected to the lower concentration of arachidonic and linoleic acid derivatives in their blood. We hypothesized that the concentration of these lipids was correlated with the extent of their body mass reduction and, thus, liver steatosis. Methods: We analyzed 68 individuals who completed the dietary intervention. Patients were divided into two groups depending on their body mass reduction (more or less than 7%). Before and after the dietary intervention, all patients had the following measurements recorded: body mass, waist circumference, stage of steatosis, fatty liver index, liver enzymes, lipid parameters, insulin and glucose. Concentrations of lipoxins A4 (LTX A4), hydroxyeicosatetraenoic fatty acids (5(S)-HETE, 12(S)-HETE and 16(S)-HETE), hydroxyoctadecaenoic acids (9(S)-HODE and 13(S)-HODE) and 5-oxo-eicosatetraenoic acid (5-oxo-ETE) were measured in serum samples collected before and after the dietetic intervention using high-performance liquid chromatography (HPLC). Results: Patients who reduced their body mass by more than 7% revealed a significant improvement in their steatosis stage, waist circumference, fatty liver index, triglycerides and cholesterol. Conclusion: A reduction in body mass by more than 7% but not by less than 7% revealed a significant improvement in steatosis stage; waist circumference; fatty liver index; and levels of triglycerides, cholesterol, 5-oxo-ETE and LTXA-4. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 2020-01-01 2020 2020-01-01 2023 2023-01-30 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/65194 |
| url |
https://hdl.handle.net/10171/65194 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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15.300719 |