Improving ocular surface comfort in contact lens wearers

Purpose Contact lens discomfort (CLD) is a major concern that can lead to the decreased or abandoned use of contact lenses. Contact lens users with dry eye disease are more likely to present with CLD. This study was conducted to evaluate the efficacy of a bioprotective preservative free, hypotonic,...

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Detalles Bibliográficos
Autores: Fernández Jiménez, Elena, Diz Arias, Elena, Peral Cerda, María Asunción
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/4699
Acceso en línea:https://hdl.handle.net/20.500.14352/4699
Access Level:acceso abierto
Palabra clave:617.7-089.243
681.73
617.71
Comfort
Contact lens
Dry eye
Ocular surface
Trehalose
Lentes de contacto
Oftalmología
Óptica y optometría
3311.11 Instrumentos ópticos
3201.09 Oftalmología
2209.15 Optometría
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oai_identifier_str oai:docta.ucm.es:20.500.14352/4699
network_acronym_str ES
network_name_str España
repository_id_str
spelling Improving ocular surface comfort in contact lens wearersMejora del comfort en la superficie ocular de usuarios de lentes de contactoFernández Jiménez, ElenaDiz Arias, ElenaPeral Cerda, María Asunción617.7-089.243681.73617.71ComfortContact lensDry eyeOcular surfaceTrehaloseLentes de contactoOftalmologíaÓptica y optometría3311.11 Instrumentos ópticos3201.09 Oftalmología2209.15 OptometríaPurpose Contact lens discomfort (CLD) is a major concern that can lead to the decreased or abandoned use of contact lenses. Contact lens users with dry eye disease are more likely to present with CLD. This study was conducted to evaluate the efficacy of a bioprotective preservative free, hypotonic, 0.15% hyaluronic acid (HA)-3% Trehalose artificial tear in managing dry eye symptoms in contact lens wearers. Methods A prospective, single-arm, observational pilot study to evaluate the effectiveness of treatment with HA-Trehalose artificial tears in contact lens wearers (N = 33) aged 18–45 years with symptoms of ocular discomfort. Participants used a preservative-free, hypotonic HA-Trehalose artificial tear (1 drop/4 times per day) for 84 days. Participants were assessed using Visual Analogue Scale (VAS) for dry eye symptoms (pain, photophobia, dry eye sensation, blurry vision, foreign body sensation, itching, tingling/burning, and sticky eye feeling), Ocular Surface Disease Index (OSDI), Contact Lens Dry Eye questionnaire (CLDEQ-8), Berkley Dry Eye Flow-Chart (DEFC) on Day 0 and Day 84 and tear break-up time (TBUT), ocular surface staining with fluorescein and lissamine green, tear meniscus evaluation, and visual acuity on Day 0, 35, and 84. Results All VAS symptoms (except tingling/burning and sticky eye feeling), OSDI, CLEDQ-8, and DEFC showed statistically significant (p < 0.05) improvement from baseline (Day 0) to Day 84. Similarly, corneal (fluorescein) and conjunctival (lissamine green) quality improved during the study (p < 0.05 at Day 84 versus baseline). Tear break-up time (TBUT), conjunctival (lissamine green) staining, and tear meniscus decreased but the changes were not statistically significant. Visual acuity did not change during the study. There were no ocular or systemic adverse events. Conclusions This study showed that the instillation of a preservative-free, hypotonic, HA-Trehalose artificial tear in contact lenses wearers with dry eye syndrome significantly improved symptoms and reduced associated signs such as corneal and conjunctival staining.ElsevierUniversidad Complutense de Madrid20212021-11-1720212021-11-17journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/4699reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/46992026-06-02T12:44:21Z
dc.title.none.fl_str_mv Improving ocular surface comfort in contact lens wearers
Mejora del comfort en la superficie ocular de usuarios de lentes de contacto
title Improving ocular surface comfort in contact lens wearers
spellingShingle Improving ocular surface comfort in contact lens wearers
Fernández Jiménez, Elena
617.7-089.243
681.73
617.71
Comfort
Contact lens
Dry eye
Ocular surface
Trehalose
Lentes de contacto
Oftalmología
Óptica y optometría
3311.11 Instrumentos ópticos
3201.09 Oftalmología
2209.15 Optometría
title_short Improving ocular surface comfort in contact lens wearers
title_full Improving ocular surface comfort in contact lens wearers
title_fullStr Improving ocular surface comfort in contact lens wearers
title_full_unstemmed Improving ocular surface comfort in contact lens wearers
title_sort Improving ocular surface comfort in contact lens wearers
dc.creator.none.fl_str_mv Fernández Jiménez, Elena
Diz Arias, Elena
Peral Cerda, María Asunción
author Fernández Jiménez, Elena
author_facet Fernández Jiménez, Elena
Diz Arias, Elena
Peral Cerda, María Asunción
author_role author
author2 Diz Arias, Elena
Peral Cerda, María Asunción
author2_role author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 617.7-089.243
681.73
617.71
Comfort
Contact lens
Dry eye
Ocular surface
Trehalose
Lentes de contacto
Oftalmología
Óptica y optometría
3311.11 Instrumentos ópticos
3201.09 Oftalmología
2209.15 Optometría
topic 617.7-089.243
681.73
617.71
Comfort
Contact lens
Dry eye
Ocular surface
Trehalose
Lentes de contacto
Oftalmología
Óptica y optometría
3311.11 Instrumentos ópticos
3201.09 Oftalmología
2209.15 Optometría
description Purpose Contact lens discomfort (CLD) is a major concern that can lead to the decreased or abandoned use of contact lenses. Contact lens users with dry eye disease are more likely to present with CLD. This study was conducted to evaluate the efficacy of a bioprotective preservative free, hypotonic, 0.15% hyaluronic acid (HA)-3% Trehalose artificial tear in managing dry eye symptoms in contact lens wearers. Methods A prospective, single-arm, observational pilot study to evaluate the effectiveness of treatment with HA-Trehalose artificial tears in contact lens wearers (N = 33) aged 18–45 years with symptoms of ocular discomfort. Participants used a preservative-free, hypotonic HA-Trehalose artificial tear (1 drop/4 times per day) for 84 days. Participants were assessed using Visual Analogue Scale (VAS) for dry eye symptoms (pain, photophobia, dry eye sensation, blurry vision, foreign body sensation, itching, tingling/burning, and sticky eye feeling), Ocular Surface Disease Index (OSDI), Contact Lens Dry Eye questionnaire (CLDEQ-8), Berkley Dry Eye Flow-Chart (DEFC) on Day 0 and Day 84 and tear break-up time (TBUT), ocular surface staining with fluorescein and lissamine green, tear meniscus evaluation, and visual acuity on Day 0, 35, and 84. Results All VAS symptoms (except tingling/burning and sticky eye feeling), OSDI, CLEDQ-8, and DEFC showed statistically significant (p < 0.05) improvement from baseline (Day 0) to Day 84. Similarly, corneal (fluorescein) and conjunctival (lissamine green) quality improved during the study (p < 0.05 at Day 84 versus baseline). Tear break-up time (TBUT), conjunctival (lissamine green) staining, and tear meniscus decreased but the changes were not statistically significant. Visual acuity did not change during the study. There were no ocular or systemic adverse events. Conclusions This study showed that the instillation of a preservative-free, hypotonic, HA-Trehalose artificial tear in contact lenses wearers with dry eye syndrome significantly improved symptoms and reduced associated signs such as corneal and conjunctival staining.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-11-17
2021
2021-11-17
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/4699
url https://hdl.handle.net/20.500.14352/4699
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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