Physical activity and association between frailty and all-causeand cardiovascular mortality in older adults: population-based prospective cohort study

Objectives: To examine the separate and joint association between physical activity and frailty and long-term all-cause and cardiovascular disease (CVD) mortality in older adults. Design: Population-based prospective cohort study. Setting: Cohort representative of the noninstitutionalized Spanish po...

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Autores: Higueras Fresnillo, Sara, Cabanas Sánchez, Verónica, López García, Esther, Esteban-Cornejo, Irene, Banegas Banegas, José Ramón, Sadarangani, Kabir P., Rodríguez Artalejo, Fernando, Martínez Gómez, David
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/710826
Acceso en línea:http://hdl.handle.net/10486/710826
https://dx.doi.org/10.1111/jgs.15542
Access Level:acceso abierto
Palabra clave:frailty
physical activity
elderly
mortality
Medicina
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spelling Physical activity and association between frailty and all-causeand cardiovascular mortality in older adults: population-based prospective cohort studyHigueras Fresnillo, SaraCabanas Sánchez, VerónicaLópez García, EstherEsteban-Cornejo, IreneBanegas Banegas, José RamónSadarangani, Kabir P.Rodríguez Artalejo, FernandoMartínez Gómez, Davidfrailtyphysical activityelderlymortalityMedicinaObjectives: To examine the separate and joint association between physical activity and frailty and long-term all-cause and cardiovascular disease (CVD) mortality in older adults. Design: Population-based prospective cohort study. Setting: Cohort representative of the noninstitutionalized Spanish population. Participants: Individuals aged 60 and older (N=3,896) in 2000-01. Measurements: Participants reported their physical activity using a validated instrument, and frailty was ascertained using the Fatigue, low Resistance, limitation in Ambulation, Illness and weight Loss (FRAIL) scale. Those with 0 frailty criteria were considered to be robust, with 1 or 2 criteria to be prefrail, and with 3 of more criteria to be frail. Participants were followed until 2014 to identify all-cause and CVD deaths. Associations were summarized using hazard ratios (HRs) and Cox regression after adjustment for main covariates. Results: During a median 14 years of follow-up, 1,801 total deaths occurred, 672 from CVD. Compared with being robust, the multivariate hazard ratio (95% confidence interval) for all-cause mortality was 1.29 (1.14-1.45) in prefrail individuals, and 2.16 (1.82-2.58) in frail individuals (p-trend <.001). Compared with being physically inactive, being physically active was associated with a statistically significant 18% (1-32%), 28% (16-39%) and 39% (17-55%) lower all-cause mortality among robust, prefrail, and frail individuals, respectively (all p <.001). Compared with participants who were robust and physically active, those who were frail and inactive showed the highest all-cause mortality 2.45 (95%CI: 1.95-3.06); however, the hazard ratio (95% confidence interval) for all-cause mortality in frail individuals who were physically active was comparable to that in pre-frail and inactive participants: 1.70 (1.32-2.19) and 1.56 (1.34-1.82), respectively. Mortality of prefrail active participants was similar to that of robust inactive participants. Results were similar for CVD mortalityWileyDepartamento de Educación Física, Deporte y Motricidad HumanaDepartamento de MedicinaFacultad de MedicinaFacultad de Formación de Profesorado y Educación20182018-05-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/710826https://dx.doi.org/10.1111/jgs.15542reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7108262026-06-23T12:46:27Z
dc.title.none.fl_str_mv Physical activity and association between frailty and all-causeand cardiovascular mortality in older adults: population-based prospective cohort study
title Physical activity and association between frailty and all-causeand cardiovascular mortality in older adults: population-based prospective cohort study
spellingShingle Physical activity and association between frailty and all-causeand cardiovascular mortality in older adults: population-based prospective cohort study
Higueras Fresnillo, Sara
frailty
physical activity
elderly
mortality
Medicina
title_short Physical activity and association between frailty and all-causeand cardiovascular mortality in older adults: population-based prospective cohort study
title_full Physical activity and association between frailty and all-causeand cardiovascular mortality in older adults: population-based prospective cohort study
title_fullStr Physical activity and association between frailty and all-causeand cardiovascular mortality in older adults: population-based prospective cohort study
title_full_unstemmed Physical activity and association between frailty and all-causeand cardiovascular mortality in older adults: population-based prospective cohort study
title_sort Physical activity and association between frailty and all-causeand cardiovascular mortality in older adults: population-based prospective cohort study
dc.creator.none.fl_str_mv Higueras Fresnillo, Sara
Cabanas Sánchez, Verónica
López García, Esther
Esteban-Cornejo, Irene
Banegas Banegas, José Ramón
Sadarangani, Kabir P.
Rodríguez Artalejo, Fernando
Martínez Gómez, David
author Higueras Fresnillo, Sara
author_facet Higueras Fresnillo, Sara
Cabanas Sánchez, Verónica
López García, Esther
Esteban-Cornejo, Irene
Banegas Banegas, José Ramón
Sadarangani, Kabir P.
Rodríguez Artalejo, Fernando
Martínez Gómez, David
author_role author
author2 Cabanas Sánchez, Verónica
López García, Esther
Esteban-Cornejo, Irene
Banegas Banegas, José Ramón
Sadarangani, Kabir P.
Rodríguez Artalejo, Fernando
Martínez Gómez, David
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Educación Física, Deporte y Motricidad Humana
Departamento de Medicina
Facultad de Medicina
Facultad de Formación de Profesorado y Educación
dc.subject.none.fl_str_mv frailty
physical activity
elderly
mortality
Medicina
topic frailty
physical activity
elderly
mortality
Medicina
description Objectives: To examine the separate and joint association between physical activity and frailty and long-term all-cause and cardiovascular disease (CVD) mortality in older adults. Design: Population-based prospective cohort study. Setting: Cohort representative of the noninstitutionalized Spanish population. Participants: Individuals aged 60 and older (N=3,896) in 2000-01. Measurements: Participants reported their physical activity using a validated instrument, and frailty was ascertained using the Fatigue, low Resistance, limitation in Ambulation, Illness and weight Loss (FRAIL) scale. Those with 0 frailty criteria were considered to be robust, with 1 or 2 criteria to be prefrail, and with 3 of more criteria to be frail. Participants were followed until 2014 to identify all-cause and CVD deaths. Associations were summarized using hazard ratios (HRs) and Cox regression after adjustment for main covariates. Results: During a median 14 years of follow-up, 1,801 total deaths occurred, 672 from CVD. Compared with being robust, the multivariate hazard ratio (95% confidence interval) for all-cause mortality was 1.29 (1.14-1.45) in prefrail individuals, and 2.16 (1.82-2.58) in frail individuals (p-trend <.001). Compared with being physically inactive, being physically active was associated with a statistically significant 18% (1-32%), 28% (16-39%) and 39% (17-55%) lower all-cause mortality among robust, prefrail, and frail individuals, respectively (all p <.001). Compared with participants who were robust and physically active, those who were frail and inactive showed the highest all-cause mortality 2.45 (95%CI: 1.95-3.06); however, the hazard ratio (95% confidence interval) for all-cause mortality in frail individuals who were physically active was comparable to that in pre-frail and inactive participants: 1.70 (1.32-2.19) and 1.56 (1.34-1.82), respectively. Mortality of prefrail active participants was similar to that of robust inactive participants. Results were similar for CVD mortality
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-05-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/710826
https://dx.doi.org/10.1111/jgs.15542
url http://hdl.handle.net/10486/710826
https://dx.doi.org/10.1111/jgs.15542
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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