Hematological parameters, lipid profile and cardiovascular risk analysis among genotype-controlled indigenous Kichwa men and women living at low and high altitudes

Introduction: Human adaptation to high-altitude is due to characteristic adjustments at every physiological level. Differences in lipid profile and cardiovascular risk factors in altitude dwellers have been previously explored, nevertheless there are no reports available on genotype-controlled match...

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Autores: Ortiz-Prado, Esteban, Portilla, David, Mosquera-Moscoso, Johanna, Simbaña-Rivera, Katherine, Duta, Diego, Ochoa, Israel, Burgos, German, Izquierdo-Condoy, Juan S., Vásconez González, Jorge Eduardo, Calvopiña, Manuel, Viscor Carrasco, Ginés
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/184775
Acceso en línea:https://hdl.handle.net/2445/184775
Access Level:acceso abierto
Palabra clave:Influència de l'altitud
Adaptació (Biologia)
Sistema cardiovascular
Influence of altitude
Adaptation (Biology)
Cardiovascular system
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spelling Hematological parameters, lipid profile and cardiovascular risk analysis among genotype-controlled indigenous Kichwa men and women living at low and high altitudesOrtiz-Prado, EstebanPortilla, DavidMosquera-Moscoso, JohannaSimbaña-Rivera, KatherineDuta, DiegoOchoa, IsraelBurgos, GermanIzquierdo-Condoy, Juan S.Vásconez González, Jorge EduardoCalvopiña, ManuelViscor Carrasco, GinésInfluència de l'altitudAdaptació (Biologia)Sistema cardiovascularInfluence of altitudeAdaptation (Biology)Cardiovascular systemIntroduction: Human adaptation to high-altitude is due to characteristic adjustments at every physiological level. Differences in lipid profile and cardiovascular risk factors in altitude dwellers have been previously explored, nevertheless there are no reports available on genotype-controlled matches among different altitude adapted indigenous populations. Objective: To explore the possible differences in plasma lipid profile and cardiovascular risk among autochthonous Kiwcha people inhabitants of low and high-altitude locations. Methodology: A cross-sectional analysis of plasmatic lipid profiles and cardiovascular risk factors in lowland Kiwchas from Limoncocha (230 m) and high-altitude Kiwchas from Oyacachi (3,800 m). Results: In the low altitude group, 66% were women (n=78) and 34% (n=40) were men, while at high altitude, 59% (n=56) were women and 41% (n=41%) were men. We found the proportion of overweight and obese individuals to be higher among low altitude dwellers (p<0.05). Red blood cells (RBC), Hemoglobin concentration and SpO2% were higher among high altitude dwellers and erythrocyte's size was found to be smaller at high altitude .The group located at low altitude showed also lower levels of plasma cholesterol, LDL and HDL but most of these differences are not influenced by gender or elevation. Conclusions: Living at altitude elicits well-known adaptive physiological changes such as erythrocyte count, hemoglobin concentration, hematocrit, and serum glucose. We report also clinical differences in the plasma lipid profile, with higher levels of cholesterol and high density and low-density lipoproteins in Andes Mountain inhabitants versus their Amazonian basin peers. Despite we found altered underlying physiological pathways between the populations, this does not allow in a different cardiovascular risk.Frontiers Media2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/184775Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3389/fphys.2021.749006Frontiers in Physiology, 2021, vol. 12, num. e749006, p. 1-14https://doi.org/10.3389/fphys.2021.749006cc-by (c) Ortiz-Prado, Esteban et al., 2021https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1847752026-05-27T06:46:51Z
dc.title.none.fl_str_mv Hematological parameters, lipid profile and cardiovascular risk analysis among genotype-controlled indigenous Kichwa men and women living at low and high altitudes
title Hematological parameters, lipid profile and cardiovascular risk analysis among genotype-controlled indigenous Kichwa men and women living at low and high altitudes
spellingShingle Hematological parameters, lipid profile and cardiovascular risk analysis among genotype-controlled indigenous Kichwa men and women living at low and high altitudes
Ortiz-Prado, Esteban
Influència de l'altitud
Adaptació (Biologia)
Sistema cardiovascular
Influence of altitude
Adaptation (Biology)
Cardiovascular system
title_short Hematological parameters, lipid profile and cardiovascular risk analysis among genotype-controlled indigenous Kichwa men and women living at low and high altitudes
title_full Hematological parameters, lipid profile and cardiovascular risk analysis among genotype-controlled indigenous Kichwa men and women living at low and high altitudes
title_fullStr Hematological parameters, lipid profile and cardiovascular risk analysis among genotype-controlled indigenous Kichwa men and women living at low and high altitudes
title_full_unstemmed Hematological parameters, lipid profile and cardiovascular risk analysis among genotype-controlled indigenous Kichwa men and women living at low and high altitudes
title_sort Hematological parameters, lipid profile and cardiovascular risk analysis among genotype-controlled indigenous Kichwa men and women living at low and high altitudes
dc.creator.none.fl_str_mv Ortiz-Prado, Esteban
Portilla, David
Mosquera-Moscoso, Johanna
Simbaña-Rivera, Katherine
Duta, Diego
Ochoa, Israel
Burgos, German
Izquierdo-Condoy, Juan S.
Vásconez González, Jorge Eduardo
Calvopiña, Manuel
Viscor Carrasco, Ginés
author Ortiz-Prado, Esteban
author_facet Ortiz-Prado, Esteban
Portilla, David
Mosquera-Moscoso, Johanna
Simbaña-Rivera, Katherine
Duta, Diego
Ochoa, Israel
Burgos, German
Izquierdo-Condoy, Juan S.
Vásconez González, Jorge Eduardo
Calvopiña, Manuel
Viscor Carrasco, Ginés
author_role author
author2 Portilla, David
Mosquera-Moscoso, Johanna
Simbaña-Rivera, Katherine
Duta, Diego
Ochoa, Israel
Burgos, German
Izquierdo-Condoy, Juan S.
Vásconez González, Jorge Eduardo
Calvopiña, Manuel
Viscor Carrasco, Ginés
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Influència de l'altitud
Adaptació (Biologia)
Sistema cardiovascular
Influence of altitude
Adaptation (Biology)
Cardiovascular system
topic Influència de l'altitud
Adaptació (Biologia)
Sistema cardiovascular
Influence of altitude
Adaptation (Biology)
Cardiovascular system
description Introduction: Human adaptation to high-altitude is due to characteristic adjustments at every physiological level. Differences in lipid profile and cardiovascular risk factors in altitude dwellers have been previously explored, nevertheless there are no reports available on genotype-controlled matches among different altitude adapted indigenous populations. Objective: To explore the possible differences in plasma lipid profile and cardiovascular risk among autochthonous Kiwcha people inhabitants of low and high-altitude locations. Methodology: A cross-sectional analysis of plasmatic lipid profiles and cardiovascular risk factors in lowland Kiwchas from Limoncocha (230 m) and high-altitude Kiwchas from Oyacachi (3,800 m). Results: In the low altitude group, 66% were women (n=78) and 34% (n=40) were men, while at high altitude, 59% (n=56) were women and 41% (n=41%) were men. We found the proportion of overweight and obese individuals to be higher among low altitude dwellers (p<0.05). Red blood cells (RBC), Hemoglobin concentration and SpO2% were higher among high altitude dwellers and erythrocyte's size was found to be smaller at high altitude .The group located at low altitude showed also lower levels of plasma cholesterol, LDL and HDL but most of these differences are not influenced by gender or elevation. Conclusions: Living at altitude elicits well-known adaptive physiological changes such as erythrocyte count, hemoglobin concentration, hematocrit, and serum glucose. We report also clinical differences in the plasma lipid profile, with higher levels of cholesterol and high density and low-density lipoproteins in Andes Mountain inhabitants versus their Amazonian basin peers. Despite we found altered underlying physiological pathways between the populations, this does not allow in a different cardiovascular risk.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/184775
url https://hdl.handle.net/2445/184775
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fphys.2021.749006
Frontiers in Physiology, 2021, vol. 12, num. e749006, p. 1-14
https://doi.org/10.3389/fphys.2021.749006
dc.rights.none.fl_str_mv cc-by (c) Ortiz-Prado, Esteban et al., 2021
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Ortiz-Prado, Esteban et al., 2021
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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