Immune-monitoring disease activity in primary membranous nephropathy

Primary membranous nephropathy (MN) is a glomerular disease mediated by autoreactive antibodies, being the main cause of nephrotic syndrome among adult patients. While the pathogenesis of MN is still controversial, the detection of autoantibodies against two specific glomerular antigens, phospholipa...

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Detalles Bibliográficos
Autores: Cravedi, Paolo, Jarque, Marta, Angeletti, Andrea, Favà Buch, Alexandre, Cantarelli, Chiara, Bestard Matamoros, Oriol
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/168439
Acceso en línea:https://hdl.handle.net/2445/168439
Access Level:acceso abierto
Palabra clave:Glomerulonefritis
Cèl·lules B
Immunologia
B cells
Immunology
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spelling Immune-monitoring disease activity in primary membranous nephropathyCravedi, PaoloJarque, MartaAngeletti, AndreaFavà Buch, AlexandreCantarelli, ChiaraBestard Matamoros, OriolGlomerulonefritisCèl·lules BImmunologiaGlomerulonefritisB cellsImmunologyPrimary membranous nephropathy (MN) is a glomerular disease mediated by autoreactive antibodies, being the main cause of nephrotic syndrome among adult patients. While the pathogenesis of MN is still controversial, the detection of autoantibodies against two specific glomerular antigens, phospholipase A2 receptor (PLA2R) and thrombospondin type 1 domain containing 7A (THSD7A), together with the beneficial effect of therapies targeting B cells, have highlighted the main role of autoreactive B cells driving this renal disease. In fact, the detection of PLA2R-specific IgG4 antibodies has resulted in a paradigm shift regarding the diagnosis as well as a better prediction of the progression and recurrence of primary MN. Nevertheless, some patients do not show remission of the nephrotic syndrome or do rapidly recur after immunosuppression withdrawal, regardless the absence of detectable anti-PLA2R antibodies, thus highlighting the need of other immune biomarkers for MN risk-stratification. Notably, the exclusive evaluation of circulating antibodies may significantly underestimate the magnitude of the global humoral memory immune response since it may exclude the role of antigen-specific memory B cells. Therefore, the assessment of PLA2R-specific B-cell immune responses using novel technologies in a functional manner may provide novel insight on the pathogenic mechanisms of B cells triggering MN as well as refine current immune-risk stratification solely based on circulating autoantibodies.Frontiers Media2020202020192020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/168439Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fmed.2019.00241Frontiers in Medicine, 2019, vol. 6, p. 241https://doi.org/10.3389/fmed.2019.00241cc-by (c) Cravedi, Paolo et al., 2019http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1684392026-05-29T05:05:01Z
dc.title.none.fl_str_mv Immune-monitoring disease activity in primary membranous nephropathy
title Immune-monitoring disease activity in primary membranous nephropathy
spellingShingle Immune-monitoring disease activity in primary membranous nephropathy
Cravedi, Paolo
Glomerulonefritis
Cèl·lules B
Immunologia
Glomerulonefritis
B cells
Immunology
title_short Immune-monitoring disease activity in primary membranous nephropathy
title_full Immune-monitoring disease activity in primary membranous nephropathy
title_fullStr Immune-monitoring disease activity in primary membranous nephropathy
title_full_unstemmed Immune-monitoring disease activity in primary membranous nephropathy
title_sort Immune-monitoring disease activity in primary membranous nephropathy
dc.creator.none.fl_str_mv Cravedi, Paolo
Jarque, Marta
Angeletti, Andrea
Favà Buch, Alexandre
Cantarelli, Chiara
Bestard Matamoros, Oriol
author Cravedi, Paolo
author_facet Cravedi, Paolo
Jarque, Marta
Angeletti, Andrea
Favà Buch, Alexandre
Cantarelli, Chiara
Bestard Matamoros, Oriol
author_role author
author2 Jarque, Marta
Angeletti, Andrea
Favà Buch, Alexandre
Cantarelli, Chiara
Bestard Matamoros, Oriol
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Glomerulonefritis
Cèl·lules B
Immunologia
Glomerulonefritis
B cells
Immunology
topic Glomerulonefritis
Cèl·lules B
Immunologia
Glomerulonefritis
B cells
Immunology
description Primary membranous nephropathy (MN) is a glomerular disease mediated by autoreactive antibodies, being the main cause of nephrotic syndrome among adult patients. While the pathogenesis of MN is still controversial, the detection of autoantibodies against two specific glomerular antigens, phospholipase A2 receptor (PLA2R) and thrombospondin type 1 domain containing 7A (THSD7A), together with the beneficial effect of therapies targeting B cells, have highlighted the main role of autoreactive B cells driving this renal disease. In fact, the detection of PLA2R-specific IgG4 antibodies has resulted in a paradigm shift regarding the diagnosis as well as a better prediction of the progression and recurrence of primary MN. Nevertheless, some patients do not show remission of the nephrotic syndrome or do rapidly recur after immunosuppression withdrawal, regardless the absence of detectable anti-PLA2R antibodies, thus highlighting the need of other immune biomarkers for MN risk-stratification. Notably, the exclusive evaluation of circulating antibodies may significantly underestimate the magnitude of the global humoral memory immune response since it may exclude the role of antigen-specific memory B cells. Therefore, the assessment of PLA2R-specific B-cell immune responses using novel technologies in a functional manner may provide novel insight on the pathogenic mechanisms of B cells triggering MN as well as refine current immune-risk stratification solely based on circulating autoantibodies.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/168439
url https://hdl.handle.net/2445/168439
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fmed.2019.00241
Frontiers in Medicine, 2019, vol. 6, p. 241
https://doi.org/10.3389/fmed.2019.00241
dc.rights.none.fl_str_mv cc-by (c) Cravedi, Paolo et al., 2019
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Cravedi, Paolo et al., 2019
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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