Novel functions of the neurodegenerative-related gene tau in cancer

The analysis of global and comparative genomics between different diseases allows us to understand the key biological processes that explain the etiology of these pathologies. We have used this type of approach to evaluate the expression of several neurodegeneration-related genes on the development...

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Detalles Bibliográficos
Autores: Gargini, Ricardo, Segura-Collar, Berta, Sánchez-Gómez, Pilar
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/215081
Acceso en línea:http://hdl.handle.net/10261/215081
Access Level:acceso abierto
Palabra clave:Tau/MAPT
Gliomas
Neurodegenerative diseases
Cancer
Tumor aggressiveness
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spelling Novel functions of the neurodegenerative-related gene tau in cancerGargini, RicardoSegura-Collar, BertaSánchez-Gómez, PilarTau/MAPTGliomasNeurodegenerative diseasesCancerTumor aggressivenessThe analysis of global and comparative genomics between different diseases allows us to understand the key biological processes that explain the etiology of these pathologies. We have used this type of approach to evaluate the expression of several neurodegeneration-related genes on the development of tumors, particularly brain tumors of glial origin (gliomas), which are an aggressive and incurable type of cancer. We have observed that genes involved in Amyotrophic lateral sclerosis (ALS), as well as in Alzheimer’s and Parkinson’s diseases, correlate with better prognosis of gliomas. Within these genes, high Tau/MAPT expression shows the strongest correlation with several indicators of prolonged survival on glioma patients. Tau protein regulates microtubule stability and dynamics in neurons, although there have been reports of its expression in glial cells and also in gliomas. However, little is known about the regulation of Tau/MAPT transcription in tumors. Moreover, our in silico analysis indicates that this gene is also expressed in a variety of tumors, showing a general correlation with survival, although its function in cancer has not yet been addressed. Another remarkable aspect of Tau is its involvement in resistance to taxanes in various tumors types such as breast, ovarian and gastric carcinomas. This is due to the fact that taxanes have the same tubulin-binding site as Tau. In the present work we review the main knowledge about Tau function and expression in tumors, with a special focus on brain cancer. We will also speculate with the therapeutic implications of these findings.Ministerio de Economía y Competitividad (MINECO-RETOS)/FEDER: SAF2015-65175-R to PS-GConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020192020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/215081reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3389/fnagi.2019.00231Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2150812026-05-22T06:33:51Z
dc.title.none.fl_str_mv Novel functions of the neurodegenerative-related gene tau in cancer
title Novel functions of the neurodegenerative-related gene tau in cancer
spellingShingle Novel functions of the neurodegenerative-related gene tau in cancer
Gargini, Ricardo
Tau/MAPT
Gliomas
Neurodegenerative diseases
Cancer
Tumor aggressiveness
title_short Novel functions of the neurodegenerative-related gene tau in cancer
title_full Novel functions of the neurodegenerative-related gene tau in cancer
title_fullStr Novel functions of the neurodegenerative-related gene tau in cancer
title_full_unstemmed Novel functions of the neurodegenerative-related gene tau in cancer
title_sort Novel functions of the neurodegenerative-related gene tau in cancer
dc.creator.none.fl_str_mv Gargini, Ricardo
Segura-Collar, Berta
Sánchez-Gómez, Pilar
author Gargini, Ricardo
author_facet Gargini, Ricardo
Segura-Collar, Berta
Sánchez-Gómez, Pilar
author_role author
author2 Segura-Collar, Berta
Sánchez-Gómez, Pilar
author2_role author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Tau/MAPT
Gliomas
Neurodegenerative diseases
Cancer
Tumor aggressiveness
topic Tau/MAPT
Gliomas
Neurodegenerative diseases
Cancer
Tumor aggressiveness
description The analysis of global and comparative genomics between different diseases allows us to understand the key biological processes that explain the etiology of these pathologies. We have used this type of approach to evaluate the expression of several neurodegeneration-related genes on the development of tumors, particularly brain tumors of glial origin (gliomas), which are an aggressive and incurable type of cancer. We have observed that genes involved in Amyotrophic lateral sclerosis (ALS), as well as in Alzheimer’s and Parkinson’s diseases, correlate with better prognosis of gliomas. Within these genes, high Tau/MAPT expression shows the strongest correlation with several indicators of prolonged survival on glioma patients. Tau protein regulates microtubule stability and dynamics in neurons, although there have been reports of its expression in glial cells and also in gliomas. However, little is known about the regulation of Tau/MAPT transcription in tumors. Moreover, our in silico analysis indicates that this gene is also expressed in a variety of tumors, showing a general correlation with survival, although its function in cancer has not yet been addressed. Another remarkable aspect of Tau is its involvement in resistance to taxanes in various tumors types such as breast, ovarian and gastric carcinomas. This is due to the fact that taxanes have the same tubulin-binding site as Tau. In the present work we review the main knowledge about Tau function and expression in tumors, with a special focus on brain cancer. We will also speculate with the therapeutic implications of these findings.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/215081
url http://hdl.handle.net/10261/215081
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.3389/fnagi.2019.00231
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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