Mild forced exercise in young mice prevents anergia induced by dopamine depletion in late adulthood: relation to CDNF and DARPP-32 phosphorylation patterns in nucleus accumbens.

Mesolimbic dopamine (DA) plays a critical role in behavioral activation and exertion of effort in motivated behaviors. DA antagonism and depletion in nucleus accumbens (Nacb) induce anergia in effort-based decision-making tasks. Exercise improves motor function in Parkinson’s disease (PD). However,...

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Detalles Bibliográficos
Autores: Olivares-García, Régulo, López Cruz, Laura, Carratalá-Ros, Carla, Matas-Navarro, Paula, Salamone, John, Correa, Merce
Tipo de recurso: conjunto de datos
Fecha de publicación:2024
País:España
Institución:Universitat Jaume I (UJI)
Repositorio:Repositori Universitat Jaume I
Idioma:inglés
OAI Identifier:oai:repositori.uji.es:10234/208339
Acceso en línea:http://hdl.handle.net/10234/208339
Access Level:acceso abierto
Palabra clave:Anergia
exercise
dopamine
CDNF
DARPP-32
Accumbens
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spelling Mild forced exercise in young mice prevents anergia induced by dopamine depletion in late adulthood: relation to CDNF and DARPP-32 phosphorylation patterns in nucleus accumbens.Olivares-García, RéguloLópez Cruz, LauraCarratalá-Ros, CarlaMatas-Navarro, PaulaSalamone, JohnCorrea, MerceAnergiaexercisedopamineCDNFDARPP-32AccumbensMesolimbic dopamine (DA) plays a critical role in behavioral activation and exertion of effort in motivated behaviors. DA antagonism and depletion in nucleus accumbens (Nacb) induce anergia in effort-based decision-making tasks. Exercise improves motor function in Parkinson’s disease (PD). However, the beneficial effects of physical exercise on anergia, a symptom present in many psychiatric and neurological pathologies needs to be studied. During 9 weeks, young CD1 male mice were trained to run at a moderate speed in automatically turning running wheels (RW) (forced exercise group) or locked in static RWs (control group) in 1 hour daily sessions. Both groups were tested in a 3-choice-T-maze task developed for the assessment of preference between active (RW) vs. sedentary reinforcers, and vulnerability to DA depletion-induced anergia was studied after tetrabenazine administration (TBZ; VMAT- 2 blocker). Exercise did not change spontaneous preferences, did not affect body weight, plasma corticosterone levels or measures of anxiety, but it did increase the cerebral DA neurotrophic factor (CDNF) in Nacb, suggesting a neuroprotective effect in these neurons. After TBZ administration, only the non-trained group showed a shift in relative preferences from active to sedentary options, reducing time running but increasing consumption of pellets, thus showing a typical anergic but not anhedonic effect. Moreover, only in the non-trained group, phosphorylation of DARPP-32(Thr34) increased after TBZ administration. These results are the first to show that mild forced exercise carried out from a young age to adulthood could act on Nacb DA-related cellular function, and prevent the anergia-inducing effects of DA depletion.Repositori UJI20242024-07-2520242024-01-0120242024-01-01datasethttp://purl.org/coar/resource_type/c_ddb1info:eu-repo/semantics/datasetapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheethttp://hdl.handle.net/10234/208339reponame:Repositori Universitat Jaume Iinstname:Universitat Jaume I (UJI)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositori.uji.es:10234/2083392026-05-29T11:39:31Z
dc.title.none.fl_str_mv Mild forced exercise in young mice prevents anergia induced by dopamine depletion in late adulthood: relation to CDNF and DARPP-32 phosphorylation patterns in nucleus accumbens.
title Mild forced exercise in young mice prevents anergia induced by dopamine depletion in late adulthood: relation to CDNF and DARPP-32 phosphorylation patterns in nucleus accumbens.
spellingShingle Mild forced exercise in young mice prevents anergia induced by dopamine depletion in late adulthood: relation to CDNF and DARPP-32 phosphorylation patterns in nucleus accumbens.
Olivares-García, Régulo
Anergia
exercise
dopamine
CDNF
DARPP-32
Accumbens
title_short Mild forced exercise in young mice prevents anergia induced by dopamine depletion in late adulthood: relation to CDNF and DARPP-32 phosphorylation patterns in nucleus accumbens.
title_full Mild forced exercise in young mice prevents anergia induced by dopamine depletion in late adulthood: relation to CDNF and DARPP-32 phosphorylation patterns in nucleus accumbens.
title_fullStr Mild forced exercise in young mice prevents anergia induced by dopamine depletion in late adulthood: relation to CDNF and DARPP-32 phosphorylation patterns in nucleus accumbens.
title_full_unstemmed Mild forced exercise in young mice prevents anergia induced by dopamine depletion in late adulthood: relation to CDNF and DARPP-32 phosphorylation patterns in nucleus accumbens.
title_sort Mild forced exercise in young mice prevents anergia induced by dopamine depletion in late adulthood: relation to CDNF and DARPP-32 phosphorylation patterns in nucleus accumbens.
dc.creator.none.fl_str_mv Olivares-García, Régulo
López Cruz, Laura
Carratalá-Ros, Carla
Matas-Navarro, Paula
Salamone, John
Correa, Merce
author Olivares-García, Régulo
author_facet Olivares-García, Régulo
López Cruz, Laura
Carratalá-Ros, Carla
Matas-Navarro, Paula
Salamone, John
Correa, Merce
author_role author
author2 López Cruz, Laura
Carratalá-Ros, Carla
Matas-Navarro, Paula
Salamone, John
Correa, Merce
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositori UJI
dc.subject.none.fl_str_mv Anergia
exercise
dopamine
CDNF
DARPP-32
Accumbens
topic Anergia
exercise
dopamine
CDNF
DARPP-32
Accumbens
description Mesolimbic dopamine (DA) plays a critical role in behavioral activation and exertion of effort in motivated behaviors. DA antagonism and depletion in nucleus accumbens (Nacb) induce anergia in effort-based decision-making tasks. Exercise improves motor function in Parkinson’s disease (PD). However, the beneficial effects of physical exercise on anergia, a symptom present in many psychiatric and neurological pathologies needs to be studied. During 9 weeks, young CD1 male mice were trained to run at a moderate speed in automatically turning running wheels (RW) (forced exercise group) or locked in static RWs (control group) in 1 hour daily sessions. Both groups were tested in a 3-choice-T-maze task developed for the assessment of preference between active (RW) vs. sedentary reinforcers, and vulnerability to DA depletion-induced anergia was studied after tetrabenazine administration (TBZ; VMAT- 2 blocker). Exercise did not change spontaneous preferences, did not affect body weight, plasma corticosterone levels or measures of anxiety, but it did increase the cerebral DA neurotrophic factor (CDNF) in Nacb, suggesting a neuroprotective effect in these neurons. After TBZ administration, only the non-trained group showed a shift in relative preferences from active to sedentary options, reducing time running but increasing consumption of pellets, thus showing a typical anergic but not anhedonic effect. Moreover, only in the non-trained group, phosphorylation of DARPP-32(Thr34) increased after TBZ administration. These results are the first to show that mild forced exercise carried out from a young age to adulthood could act on Nacb DA-related cellular function, and prevent the anergia-inducing effects of DA depletion.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-07-25
2024
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv dataset
http://purl.org/coar/resource_type/c_ddb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/dataset
format dataset
dc.identifier.none.fl_str_mv http://hdl.handle.net/10234/208339
url http://hdl.handle.net/10234/208339
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
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http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
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http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Repositori Universitat Jaume I
instname:Universitat Jaume I (UJI)
instname_str Universitat Jaume I (UJI)
reponame_str Repositori Universitat Jaume I
collection Repositori Universitat Jaume I
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