Assessment of protein folding potentials with an evolutionary method
Many different protein folding potentials have been developed in the last decades, based upon knowledge of experimentally determined protein structures. Decoy-based techniques are frequently used to assess these force fields, but other methods can explore different features in the performance of the...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2006 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/92631 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/92631 |
| Access Level: | acceso abierto |
| Palabra clave: | 544 Química física (Química) 2307 Química Física 2302.27 Proteínas |
| Sumario: | Many different protein folding potentials have been developed in the last decades, based upon knowledge of experimentally determined protein structures. Decoy-based techniques are frequently used to assess these force fields, but other methods can explore different features in the performance of the interaction schemes, thus helping in their evaluation. Here, we propose an evolutionary strategy to efficiently assess folding potentials. We apply it to three potentials with different characteristics, taken from the bibliography. A search for minimum energy protein topologies, treated as arrangements of rigid protein fragments, is performed. The method, applied to a set of helix bundle proteins, shows the different behavior of the studied potentials, providing a reasonably fast tool to evaluate their advantages and limitations. |
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