LAG3 genotype of the donor and clinical outcome after allogeneic transplantation from HLA-identical sibling donors

The association of polymorphisms in molecules involved in the immune response (checkpoint inhibitors) with the clinical outcome after allogeneic transplantation (alloHSCT) has been described. Lymphocyte Activation 3 (LAG3) is a surface protein that plays a regulatory role in immunity as an inhibitor...

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Detalles Bibliográficos
Autores: Cruz, David, Rodríguez-Romanos, Rocío|||0000-0002-2827-7074, González-Bartulos, Marta, García Cadenas, Irene|||0000-0002-2994-9055, de la Camara, Rafael|||0000-0002-8189-5779, Heras, Inmaculada, Buño, Ismael|||0000-0003-4931-9170, Santos, Nazly, Lloveras, Natàlia|||0000-0002-9063-2241, Velarde, Pilar, Tuset, Esperanza|||0000-0002-1463-6689, Martínez, Carmen|||0000-0002-8401-7306, González, Marcos, Sanz, Guillermo F., Ferrá, Christelle|||0000-0003-4571-5125, Sampol, Antonia|||0000-0001-7465-6203, Coll, Rosa|||0000-0003-0560-1254, Pérez-Simón, Jose A., López-Jiménez, Javier, Jurado, Manuel|||0000-0001-9156-3797, Gallardo, David|||0000-0003-1615-4592
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:277630
Acceso en línea:https://ddd.uab.cat/record/277630
https://dx.doi.org/urn:doi:10.3389/fimmu.2023.1066393
Access Level:acceso abierto
Palabra clave:LAG3: lymphocyte activation gene 3
Graft-versus-host disease
Allogeneic transplant
Immune response
Checkpoint molecules
Descripción
Sumario:The association of polymorphisms in molecules involved in the immune response (checkpoint inhibitors) with the clinical outcome after allogeneic transplantation (alloHSCT) has been described. Lymphocyte Activation 3 (LAG3) is a surface protein that plays a regulatory role in immunity as an inhibitory immune checkpoint molecule. To determine its role in the alloHSCT setting, we analyzed 797 patients transplanted from HLA-identical sibling donors. The LAG3 rs870849 C.

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