Synergistic effect of two formulations of hypochlorous acid in the treatment of 346 chronic ulcers

Our objective was to assess the efficacy of two successive applications of hypochlorous acid, first as a liquid and then as a gel because liquid hypochlorous acid is effective but has little residual effect, while the gel form has more residual power, and compare it with that of other products. An e...

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Autores: Herruzo Cabrera, Rafael, Fondo Alvarez, Erika, Herruzo, Irene, Santiso Casanova, Emma, Cerame Perez, Silvia
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/707197
Acceso en línea:http://hdl.handle.net/10486/707197
https://dx.doi.org/10.1111/wrr.13079
Access Level:acceso abierto
Palabra clave:HOCl-gel
HOCl-liquid
Synergy
Ulcers healing
Medicina
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spelling Synergistic effect of two formulations of hypochlorous acid in the treatment of 346 chronic ulcersHerruzo Cabrera, RafaelFondo Alvarez, ErikaHerruzo, IreneSantiso Casanova, EmmaCerame Perez, SilviaHOCl-gelHOCl-liquidSynergyUlcers healingMedicinaOur objective was to assess the efficacy of two successive applications of hypochlorous acid, first as a liquid and then as a gel because liquid hypochlorous acid is effective but has little residual effect, while the gel form has more residual power, and compare it with that of other products. An experimental non-randomised study was carried out, treating 346 chronic ulcers in 220 patients. The antiseptic treatment has been divided into ‘hypochlorous acid’ (Clortech), ‘hypochlorous acid liquid + gel’ (Clortech + Microdacyn60R-hydrogel) and ‘Others’ (Prontosan or Chlorhexidine or Microdacyn60R-hydrogel). Bivariate and multivariate studies analysed the characteristics of the patients and their ulcers, including size, symptoms, signs, treatments received and their duration, and so on. The ulcers were complicated, of long evolution, and most had a vascular origin. On average, antiseptic treatment lasted 14 weeks. At the time of their discharge, or last treatment in the clinics, 59% of the ulcers had healed completely, 9.5% worsened, and 6.9% had become infected during this period. In the bivariate and multivariate studies, we took as reference the ‘others’ treatments that showed no significant differences in healing time or infection rates compared with liquid hypochlorous acid 100–500 mg/L alone. However, hypochlorous acid liquid + gel showed a synergistic effect, with a higher probability of achieving complete healing (four times) and a lower probability of infection (a fifth), compared to the ‘other’ antiseptics. In conclusion, a synergistic effect was found with the successive application of hypochlorous acid in liquid followed by gel, an effect that increased healing probability and decreased the risk of the ulcer becoming infectedWileyDepartamento de Medicina Preventiva y Salud Pública y MicrobiologíaFacultad de Medicina20232023-03-23research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/707197https://dx.doi.org/10.1111/wrr.13079reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7071972026-06-23T12:46:27Z
dc.title.none.fl_str_mv Synergistic effect of two formulations of hypochlorous acid in the treatment of 346 chronic ulcers
title Synergistic effect of two formulations of hypochlorous acid in the treatment of 346 chronic ulcers
spellingShingle Synergistic effect of two formulations of hypochlorous acid in the treatment of 346 chronic ulcers
Herruzo Cabrera, Rafael
HOCl-gel
HOCl-liquid
Synergy
Ulcers healing
Medicina
title_short Synergistic effect of two formulations of hypochlorous acid in the treatment of 346 chronic ulcers
title_full Synergistic effect of two formulations of hypochlorous acid in the treatment of 346 chronic ulcers
title_fullStr Synergistic effect of two formulations of hypochlorous acid in the treatment of 346 chronic ulcers
title_full_unstemmed Synergistic effect of two formulations of hypochlorous acid in the treatment of 346 chronic ulcers
title_sort Synergistic effect of two formulations of hypochlorous acid in the treatment of 346 chronic ulcers
dc.creator.none.fl_str_mv Herruzo Cabrera, Rafael
Fondo Alvarez, Erika
Herruzo, Irene
Santiso Casanova, Emma
Cerame Perez, Silvia
author Herruzo Cabrera, Rafael
author_facet Herruzo Cabrera, Rafael
Fondo Alvarez, Erika
Herruzo, Irene
Santiso Casanova, Emma
Cerame Perez, Silvia
author_role author
author2 Fondo Alvarez, Erika
Herruzo, Irene
Santiso Casanova, Emma
Cerame Perez, Silvia
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Medicina Preventiva y Salud Pública y Microbiología
Facultad de Medicina
dc.subject.none.fl_str_mv HOCl-gel
HOCl-liquid
Synergy
Ulcers healing
Medicina
topic HOCl-gel
HOCl-liquid
Synergy
Ulcers healing
Medicina
description Our objective was to assess the efficacy of two successive applications of hypochlorous acid, first as a liquid and then as a gel because liquid hypochlorous acid is effective but has little residual effect, while the gel form has more residual power, and compare it with that of other products. An experimental non-randomised study was carried out, treating 346 chronic ulcers in 220 patients. The antiseptic treatment has been divided into ‘hypochlorous acid’ (Clortech), ‘hypochlorous acid liquid + gel’ (Clortech + Microdacyn60R-hydrogel) and ‘Others’ (Prontosan or Chlorhexidine or Microdacyn60R-hydrogel). Bivariate and multivariate studies analysed the characteristics of the patients and their ulcers, including size, symptoms, signs, treatments received and their duration, and so on. The ulcers were complicated, of long evolution, and most had a vascular origin. On average, antiseptic treatment lasted 14 weeks. At the time of their discharge, or last treatment in the clinics, 59% of the ulcers had healed completely, 9.5% worsened, and 6.9% had become infected during this period. In the bivariate and multivariate studies, we took as reference the ‘others’ treatments that showed no significant differences in healing time or infection rates compared with liquid hypochlorous acid 100–500 mg/L alone. However, hypochlorous acid liquid + gel showed a synergistic effect, with a higher probability of achieving complete healing (four times) and a lower probability of infection (a fifth), compared to the ‘other’ antiseptics. In conclusion, a synergistic effect was found with the successive application of hypochlorous acid in liquid followed by gel, an effect that increased healing probability and decreased the risk of the ulcer becoming infected
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-03-23
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/707197
https://dx.doi.org/10.1111/wrr.13079
url http://hdl.handle.net/10486/707197
https://dx.doi.org/10.1111/wrr.13079
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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