Donor CTLA-4 Genotype Modulates the Immune Response to Minor Histocompatibility Antigen Mismatches

Minor histocompatibility antigen (miHA) mismatches have been related to graft-versus-host disease (GVHD) after allogeneic stem cell transplantation, but this association remains controversial due to the lack of consistency in the results obtained by different groups. The CTLA-4 genotype of the donor...

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Detalhes bibliográficos
Autores: Gallardo, David, Bosch-Vizcaya, Anna, Rodriguez-Romanos, Rocio, Santos, Nazly, Buño, Ismael, de la Cámara, Rafael, Brunet, Salut, Jimenez-Velasco, Antonio, Gonzalez, Marcos, Nieto, Jose B., Martinez-Laperche, Carolina, Vallejo, Carlos, Ferra, Christelle, Sampol Mayol, Antonia, Lopez-Jimenez, Javier, Perez-Simon, Jose A., Martinez, Carmen, Diez, Jose-Luis, Spanish Hematopoietic Transplant
Formato: artículo
Fecha de publicación:2017
País:España
Recursos:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/17289
Acesso em linha:https://hdl.handle.net/20.500.13003/17289
Access Level:acceso abierto
Palavra-chave:Immunity
Child, Preschool
Adolescent
Middle Aged
Infant
Graft vs Host Disease
Tissue Donors
Minor Histocompatibility Antigens
Genotype
Child
Aged
CTLA-4 Antigen
Young Adult
Adult
Histocompatibility
Humans
Antígeno CTLA-4
Antígenos de Histocompatibilidad Menor
Enfermedad Injerto contra Huésped
Donantes de Tejidos
Lactante
Adolescente
Inmunidad
Preescolar
Histocompatibilidad
Humanos
Persona de Mediana Edad
Adulto Joven
Anciano
Genotipo
Niño
Adulto
CTLA-4
Minor histocompatibility antigens
Graft-versus-host disease
Allogeneic transplantation
Descrição
Resumo:Minor histocompatibility antigen (miHA) mismatches have been related to graft-versus-host disease (GVHD) after allogeneic stem cell transplantation, but this association remains controversial due to the lack of consistency in the results obtained by different groups. The CTLA-4 genotype of the donor has been reported to be relevant in the appearance of acute GVHD. We explored the effect of the donor's CTLA-4 genotype in the incidence of acute GVHD associated with HA-1, HA-8, or H-Y miHA mismatches in a large cohort of 1295 patients receiving an allogeneic transplant from an HLA-identical sibling donor. The incidence of acute GVHD was higher if the donor and recipient were mismatched for HA-1, HA-8, or H-Y, but only when the donor had the CTLA-4 rs231775 AA genotype (hazard ratio [HR], 2.18; 95% confidence interval [CI], 1.27 to 3.75; P=.005; HR, 2.11, 95% CI, 1.06 to 4.18; P=.033; and HR, 1.50; 95% CI, 1.05 to 2.15; P=.025, respectively). In contrast, this increased risk of developing acute GVHD was not found when the donor presented the CTLA-4 rs231775 AG or GG genotypes. We conclude that the immune response to specific miHA mismatches is modulated by the CTLA-4 genotype of the donor.

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