The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health

White adipose tissue (WAT) is a highly adaptive endocrine organ that continuously remodels in response to nutritional cues. WAT expands to store excess energy by increasing adipocyte number and/or size. Failure in WAT expansion has serious consequences on metabolic health resulting in altered lipid,...

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Detalhes bibliográficos
Autores: Clemente-Postigo, Mercedes, Tinahones, Alberto, El Bekay, Rajaa, Malagón, María M., Tinahones, Francisco J.
Formato: artículo
Fecha de publicación:2020
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/18038
Acesso em linha:http://hdl.handle.net/20.500.12105/18038
Access Level:acceso abierto
Palavra-chave:Adipose tissue
Adipocyte
Autophagy
Obesity
Diabetes
Metabolism
Tejido adiposo
Adipocitos
Autofagia
Obesidad
Diabetes Mellitus
Metabolismo
Adipose Tissue
Adipocytes
Adipogenesis
Humans
Homeostasis
Fibrosis
Inflammation
Lipids
Glucose
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spelling The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic HealthClemente-Postigo, MercedesTinahones, AlbertoEl Bekay, RajaaMalagón, María M.Tinahones, Francisco J.Adipose tissueAdipocyteAutophagyObesityDiabetesMetabolismTejido adiposoAdipocitosAutofagiaObesidadDiabetes MellitusMetabolismoAdipose TissueAdipocytesAutophagyObesityDiabetes MellitusMetabolismAdipogenesisHumansHomeostasisFibrosisInflammationLipidsGlucoseWhite adipose tissue (WAT) is a highly adaptive endocrine organ that continuously remodels in response to nutritional cues. WAT expands to store excess energy by increasing adipocyte number and/or size. Failure in WAT expansion has serious consequences on metabolic health resulting in altered lipid, glucose, and inflammatory profiles. Besides an impaired adipogenesis, fibrosis and low-grade inflammation also characterize dysfunctional WAT. Nevertheless, the precise mechanisms leading to impaired WAT expansibility are yet unresolved. Autophagy is a conserved and essential process for cellular homeostasis, which constitutively allows the recycling of damaged or long-lived proteins and organelles, but is also highly induced under stress conditions to provide nutrients and remove pathogens. By modulating protein and organelle content, autophagy is also essential for cell remodeling, maintenance, and survival. In this line, autophagy has been involved in many processes affected during WAT maladaptation, including adipogenesis, adipocyte, and macrophage function, inflammatory response, and fibrosis. WAT autophagy dysregulation is related to obesity and diabetes. However, it remains unclear whether WAT autophagy alteration in obese and diabetic patients are the cause or the consequence of WAT malfunction. In this review, current data regarding these issues are discussed, focusing on evidence from human studies.Multidisciplinary Digital Publishing Institute (MDPI)[Clemente-Postigo,M; Malagón,MM] Department of Cell Biology, Physiology and Immunology, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)-Reina Sofia University Hospital, University of Cordoba, Edificio IMIBIC, Córdoba, Spain. [Tinahones,A; Tinahones,FJ] Unidad de Gestión Clínica de Endocrinología y Nutrición (Hospital Universitario Virgen de la Victoria), Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain. [El Bekay,R] Unidad de Gestión Clínica de Endocrinología y Nutrición (Hospital Universitario Regional de Málaga), Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain. [El Bekay,R; Malagón,MM; Tinahones,FJ] Centro de Investigación Biomédica en Red (CIBER) Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.20242024-02-1220202020-04-3020202020-04-30review articlehttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/18038reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/180382026-06-12T12:43:37Z
dc.title.none.fl_str_mv The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health
title The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health
spellingShingle The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health
Clemente-Postigo, Mercedes
Adipose tissue
Adipocyte
Autophagy
Obesity
Diabetes
Metabolism
Tejido adiposo
Adipocitos
Autofagia
Obesidad
Diabetes Mellitus
Metabolismo
Adipose Tissue
Adipocytes
Autophagy
Obesity
Diabetes Mellitus
Metabolism
Adipogenesis
Humans
Homeostasis
Fibrosis
Inflammation
Lipids
Glucose
title_short The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health
title_full The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health
title_fullStr The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health
title_full_unstemmed The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health
title_sort The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health
dc.creator.none.fl_str_mv Clemente-Postigo, Mercedes
Tinahones, Alberto
El Bekay, Rajaa
Malagón, María M.
Tinahones, Francisco J.
author Clemente-Postigo, Mercedes
author_facet Clemente-Postigo, Mercedes
Tinahones, Alberto
El Bekay, Rajaa
Malagón, María M.
Tinahones, Francisco J.
author_role author
author2 Tinahones, Alberto
El Bekay, Rajaa
Malagón, María M.
Tinahones, Francisco J.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv [Clemente-Postigo,M; Malagón,MM] Department of Cell Biology, Physiology and Immunology, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)-Reina Sofia University Hospital, University of Cordoba, Edificio IMIBIC, Córdoba, Spain. [Tinahones,A; Tinahones,FJ] Unidad de Gestión Clínica de Endocrinología y Nutrición (Hospital Universitario Virgen de la Victoria), Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain. [El Bekay,R] Unidad de Gestión Clínica de Endocrinología y Nutrición (Hospital Universitario Regional de Málaga), Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain. [El Bekay,R; Malagón,MM; Tinahones,FJ] Centro de Investigación Biomédica en Red (CIBER) Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
dc.subject.none.fl_str_mv Adipose tissue
Adipocyte
Autophagy
Obesity
Diabetes
Metabolism
Tejido adiposo
Adipocitos
Autofagia
Obesidad
Diabetes Mellitus
Metabolismo
Adipose Tissue
Adipocytes
Autophagy
Obesity
Diabetes Mellitus
Metabolism
Adipogenesis
Humans
Homeostasis
Fibrosis
Inflammation
Lipids
Glucose
topic Adipose tissue
Adipocyte
Autophagy
Obesity
Diabetes
Metabolism
Tejido adiposo
Adipocitos
Autofagia
Obesidad
Diabetes Mellitus
Metabolismo
Adipose Tissue
Adipocytes
Autophagy
Obesity
Diabetes Mellitus
Metabolism
Adipogenesis
Humans
Homeostasis
Fibrosis
Inflammation
Lipids
Glucose
description White adipose tissue (WAT) is a highly adaptive endocrine organ that continuously remodels in response to nutritional cues. WAT expands to store excess energy by increasing adipocyte number and/or size. Failure in WAT expansion has serious consequences on metabolic health resulting in altered lipid, glucose, and inflammatory profiles. Besides an impaired adipogenesis, fibrosis and low-grade inflammation also characterize dysfunctional WAT. Nevertheless, the precise mechanisms leading to impaired WAT expansibility are yet unresolved. Autophagy is a conserved and essential process for cellular homeostasis, which constitutively allows the recycling of damaged or long-lived proteins and organelles, but is also highly induced under stress conditions to provide nutrients and remove pathogens. By modulating protein and organelle content, autophagy is also essential for cell remodeling, maintenance, and survival. In this line, autophagy has been involved in many processes affected during WAT maladaptation, including adipogenesis, adipocyte, and macrophage function, inflammatory response, and fibrosis. WAT autophagy dysregulation is related to obesity and diabetes. However, it remains unclear whether WAT autophagy alteration in obese and diabetic patients are the cause or the consequence of WAT malfunction. In this review, current data regarding these issues are discussed, focusing on evidence from human studies.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-04-30
2020
2020-04-30
2024
2024-02-12
dc.type.none.fl_str_mv review article
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/18038
url http://hdl.handle.net/20.500.12105/18038
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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