Potency and durability of T and B cell immune responses after homologous and heterologous vector delivery of a trimer-stabilized, membrane-displayed HIV-1 clade ConC Env protein

The generation of an HIV-1 vaccine able to induce long-lasting protective immunity remains a main challenge. Here, we aimed to modify next-generation soluble, prefusion-stabilized, close-to-native, glycan-engineered clade C gp140 envelope (Env) trimers (sC23v4 KIKO and ConCv5 KIKO) for optimal displ...

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Detalhes bibliográficos
Autores: Perdiguero, Beatriz, Hauser, Alexandra, Gómez, Carmen Elena, Peterhoff, David, Sideris, Elefthéria, Sorzano, Carlos Óscar S., Wilmschen, Sarah, Schaber, Marion, Stengel, Laura, Asbach, Benedikt, Ding, Song, Von Laer, Dorothee, Levy, Yves, Pantaleo, Giuseppe, Kimpel, Janine, Esteban, Mariano, Wagner, Ralf
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/363707
Acesso em linha:http://hdl.handle.net/10261/363707
https://api.elsevier.com/content/abstract/scopus_id/85178489523
Access Level:acceso abierto
Palavra-chave:DNA
HIV-1 vaccine
T and B cells
VSV-GP and NYVAC vectors
antibodies
membrane display
mice immunization
trimeric ConCv5 KIKO protein
Descrição
Resumo:The generation of an HIV-1 vaccine able to induce long-lasting protective immunity remains a main challenge. Here, we aimed to modify next-generation soluble, prefusion-stabilized, close-to-native, glycan-engineered clade C gp140 envelope (Env) trimers (sC23v4 KIKO and ConCv5 KIKO) for optimal display on the cell surface following homologous or heterologous vector delivery.

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