Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers

Objectives: We investigated the association between outdoor air pollutants exposure in the first trimester of pregnancy, and growth and cardio-metabolic risk at four years of age, and evaluated the mediating role of birth weight. Methods: We included mother-child pairs (N = 1,724) from the Spanish I...

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Autores: Fossati S, Valvi D, Martinez D, Cirach M, Estarlich M, Fernández-Somoano A, Guxens M, Iñiguez C, Irizar A, Lertxundi A, Nieuwenhuijsen M, Tamayo I, Vioque J, Tardón A, Sunyer J, Vrijheid M
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p7218
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/7218
Access Level:acceso abierto
Palabra clave:Air pollution
Prenatal exposure
Childhood growth
Childhood obesity
Particulate matter
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spelling Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolersFossati SValvi DMartinez DCirach MEstarlich MFernández-Somoano AGuxens MIñiguez CIrizar ALertxundi ANieuwenhuijsen MTamayo IVioque JTardón ASunyer JVrijheid MAir pollutionPrenatal exposureChildhood growthChildhood obesityParticulate matterObjectives: We investigated the association between outdoor air pollutants exposure in the first trimester of pregnancy, and growth and cardio-metabolic risk at four years of age, and evaluated the mediating role of birth weight. Methods: We included mother-child pairs (N = 1,724) from the Spanish INMA birth cohort established in 2003-2008. First trimester of pregnancy nitrogen dioxide (NO2) and fine particles (PM2.5) exposure levels were estimated. Height, weight, waist circumference, blood pressure, and lipids were measured at four years of age. Body mass index (BMI) trajectories from birth to four years were identified. Results: Increased PM2.5 exposure in the first trimester of pregnancy was associated with decreased z-scores of weight (zWeight) and BMI (zBMI) (zWeight change per interquartile range increase in PM2.5 exposure = -0.12; 95% CI: -0.23, -0.01; zBMI change = -0.12; 95% CI: -0.23, -0.01). Higher NO2 and PM2.5 exposure was associated to a reduced risk of being in a trajectory with accelerated BMI gain, compared to children with the average trajectory. Birth weight partially mediated the association between PM2.5 and zWeight and zBMI. PM2.5 and NO2 were not associated with the other cardio-metabolic risk factors. Conclusions: This comprehensive study of many growth and cardio-metabolic risk related outcomes suggests that air pollution exposure during pregnancy may be associated with delays in physical growth in the early years after birth. These findings imply that pregnancy exposure to air pollutants has a lasting effect on growth after birth and require follow-up at later child ages.PERGAMON-ELSEVIER SCIENCE LTD2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/7218ENVIRONMENT INTERNATIONALISSN: 01604120ISSNe: 18736750reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p72182026-06-11T12:45:17Z
dc.title.none.fl_str_mv Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers
title Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers
spellingShingle Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers
Fossati S
Air pollution
Prenatal exposure
Childhood growth
Childhood obesity
Particulate matter
title_short Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers
title_full Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers
title_fullStr Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers
title_full_unstemmed Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers
title_sort Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers
dc.creator.none.fl_str_mv Fossati S
Valvi D
Martinez D
Cirach M
Estarlich M
Fernández-Somoano A
Guxens M
Iñiguez C
Irizar A
Lertxundi A
Nieuwenhuijsen M
Tamayo I
Vioque J
Tardón A
Sunyer J
Vrijheid M
author Fossati S
author_facet Fossati S
Valvi D
Martinez D
Cirach M
Estarlich M
Fernández-Somoano A
Guxens M
Iñiguez C
Irizar A
Lertxundi A
Nieuwenhuijsen M
Tamayo I
Vioque J
Tardón A
Sunyer J
Vrijheid M
author_role author
author2 Valvi D
Martinez D
Cirach M
Estarlich M
Fernández-Somoano A
Guxens M
Iñiguez C
Irizar A
Lertxundi A
Nieuwenhuijsen M
Tamayo I
Vioque J
Tardón A
Sunyer J
Vrijheid M
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Air pollution
Prenatal exposure
Childhood growth
Childhood obesity
Particulate matter
topic Air pollution
Prenatal exposure
Childhood growth
Childhood obesity
Particulate matter
description Objectives: We investigated the association between outdoor air pollutants exposure in the first trimester of pregnancy, and growth and cardio-metabolic risk at four years of age, and evaluated the mediating role of birth weight. Methods: We included mother-child pairs (N = 1,724) from the Spanish INMA birth cohort established in 2003-2008. First trimester of pregnancy nitrogen dioxide (NO2) and fine particles (PM2.5) exposure levels were estimated. Height, weight, waist circumference, blood pressure, and lipids were measured at four years of age. Body mass index (BMI) trajectories from birth to four years were identified. Results: Increased PM2.5 exposure in the first trimester of pregnancy was associated with decreased z-scores of weight (zWeight) and BMI (zBMI) (zWeight change per interquartile range increase in PM2.5 exposure = -0.12; 95% CI: -0.23, -0.01; zBMI change = -0.12; 95% CI: -0.23, -0.01). Higher NO2 and PM2.5 exposure was associated to a reduced risk of being in a trajectory with accelerated BMI gain, compared to children with the average trajectory. Birth weight partially mediated the association between PM2.5 and zWeight and zBMI. PM2.5 and NO2 were not associated with the other cardio-metabolic risk factors. Conclusions: This comprehensive study of many growth and cardio-metabolic risk related outcomes suggests that air pollution exposure during pregnancy may be associated with delays in physical growth in the early years after birth. These findings imply that pregnancy exposure to air pollutants has a lasting effect on growth after birth and require follow-up at later child ages.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/7218
url https://fisabio.portalinvestigacion.com/publicaciones/7218
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv PERGAMON-ELSEVIER SCIENCE LTD
publisher.none.fl_str_mv PERGAMON-ELSEVIER SCIENCE LTD
dc.source.none.fl_str_mv ENVIRONMENT INTERNATIONAL
ISSN: 01604120
ISSNe: 18736750
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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