Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients

Sans de San Nicolàs, Lídia; Figueras Nart, Ignasi; García-Jiménez, Irene; Bonfill Ortí, Montserrat; Guilabert, Antonio; Curto Barredo, Laia; Bertolín Colilla, Marta; Ferran, Marta; Serra Baldrich, Esther; Pujol, Ramon M.; Santamaria Babí, Luis F.

Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients

Background:The role of allergen sensitization in IL-31 production by T cells and specifically in the clinical context of atopic dermatitis (AD) has not been characterized. MethodsThe response to house dust mite (HDM) in purified memory T cells cocultured with epidermal cells from AD patients (n=58)...

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Autores:	Sans de San Nicolàs, Lídia, Figueras Nart, Ignasi, García-Jiménez, Irene, Bonfill Ortí, Montserrat, Guilabert, Antonio, Curto Barredo, Laia, Bertolín Colilla, Marta, Ferran, Marta, Serra Baldrich, Esther, Pujol, Ramon M., Santamaria Babí, Luis F.
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2023
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/197180
Acceso en línea:	https://hdl.handle.net/2445/197180
Access Level:	acceso abierto
Palabra clave:	Dermatitis atòpica Al·lèrgens Citocines Cèl·lules T Atopic dermatitis Allergens Cytokines T cells

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spelling	Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patientsSans de San Nicolàs, LídiaFigueras Nart, IgnasiGarcía-Jiménez, IreneBonfill Ortí, MontserratGuilabert, AntonioCurto Barredo, LaiaBertolín Colilla, MartaFerran, MartaSerra Baldrich, EstherPujol, Ramon M.Santamaria Babí, Luis F.Dermatitis atòpicaAl·lèrgensCitocinesCèl·lules TAtopic dermatitisAllergensCytokinesT cellsBackground:The role of allergen sensitization in IL-31 production by T cells and specifically in the clinical context of atopic dermatitis (AD) has not been characterized. MethodsThe response to house dust mite (HDM) in purified memory T cells cocultured with epidermal cells from AD patients (n=58) and control subjects (n=11) was evaluated. AD-associated cytokines from culture supernatants, plasma proteins and mRNA expression from cutaneous lesions were assessed and related with the clinical features of the patients. ResultsHDM-induced IL-31 production by memory T cells defined two subsets of AD patients according to the presence or absence of IL-31 response. Patients in the IL-31 producing group showed a more inflammatory profile, and increased HDM-specific (sp) and total IgE levels compared to the IL-31 non-producing group. A correlation between IL-31 production and patient's pruritus intensity, plasma CCL27 and periostin was detected. When the same patients were analyzed based on sp IgE and total IgE levels, an increased IL-31 in vitro response, as well as type 2 markers in plasma and cutaneous lesions, was found in patients with sp IgE levels > 100 kUA/L and total IgE levels > 1000 kU/L. The IL-31 response by memory T cells was restricted to the cutaneous lymphocyte-associated antigen (CLA)(+) T-cell subset. ConclusionIgE sensitization to HDM allows stratifying IL-31 production by memory T cells in AD patients and relating it to particular clinical phenotypes of the disease.Frontiers Media SA2023202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/197180Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fimmu.2023.1124018Frontiers in Immunology, 2023, vol. 14, num. 1124018https://doi.org/10.3389/fimmu.2023.1124018cc by (c) Sans de San Nicolàs, Lídia et al., 2023http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1971802026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients
title	Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients
spellingShingle	Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients Sans de San Nicolàs, Lídia Dermatitis atòpica Al·lèrgens Citocines Cèl·lules T Atopic dermatitis Allergens Cytokines T cells
title_short	Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients
title_full	Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients
title_fullStr	Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients
title_full_unstemmed	Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients
title_sort	Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients
dc.creator.none.fl_str_mv	Sans de San Nicolàs, Lídia Figueras Nart, Ignasi García-Jiménez, Irene Bonfill Ortí, Montserrat Guilabert, Antonio Curto Barredo, Laia Bertolín Colilla, Marta Ferran, Marta Serra Baldrich, Esther Pujol, Ramon M. Santamaria Babí, Luis F.
author	Sans de San Nicolàs, Lídia
author_facet	Sans de San Nicolàs, Lídia Figueras Nart, Ignasi García-Jiménez, Irene Bonfill Ortí, Montserrat Guilabert, Antonio Curto Barredo, Laia Bertolín Colilla, Marta Ferran, Marta Serra Baldrich, Esther Pujol, Ramon M. Santamaria Babí, Luis F.
author_role	author
author2	Figueras Nart, Ignasi García-Jiménez, Irene Bonfill Ortí, Montserrat Guilabert, Antonio Curto Barredo, Laia Bertolín Colilla, Marta Ferran, Marta Serra Baldrich, Esther Pujol, Ramon M. Santamaria Babí, Luis F.
author2_role	author author author author author author author author author author
dc.subject.none.fl_str_mv	Dermatitis atòpica Al·lèrgens Citocines Cèl·lules T Atopic dermatitis Allergens Cytokines T cells
topic	Dermatitis atòpica Al·lèrgens Citocines Cèl·lules T Atopic dermatitis Allergens Cytokines T cells
description	Background:The role of allergen sensitization in IL-31 production by T cells and specifically in the clinical context of atopic dermatitis (AD) has not been characterized. MethodsThe response to house dust mite (HDM) in purified memory T cells cocultured with epidermal cells from AD patients (n=58) and control subjects (n=11) was evaluated. AD-associated cytokines from culture supernatants, plasma proteins and mRNA expression from cutaneous lesions were assessed and related with the clinical features of the patients. ResultsHDM-induced IL-31 production by memory T cells defined two subsets of AD patients according to the presence or absence of IL-31 response. Patients in the IL-31 producing group showed a more inflammatory profile, and increased HDM-specific (sp) and total IgE levels compared to the IL-31 non-producing group. A correlation between IL-31 production and patient's pruritus intensity, plasma CCL27 and periostin was detected. When the same patients were analyzed based on sp IgE and total IgE levels, an increased IL-31 in vitro response, as well as type 2 markers in plasma and cutaneous lesions, was found in patients with sp IgE levels > 100 kUA/L and total IgE levels > 1000 kU/L. The IL-31 response by memory T cells was restricted to the cutaneous lymphocyte-associated antigen (CLA)(+) T-cell subset. ConclusionIgE sensitization to HDM allows stratifying IL-31 production by memory T cells in AD patients and relating it to particular clinical phenotypes of the disease.
publishDate	2023
dc.date.none.fl_str_mv	2023 2023 2023 2023
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/197180
url	https://hdl.handle.net/2445/197180
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2023.1124018 Frontiers in Immunology, 2023, vol. 14, num. 1124018 https://doi.org/10.3389/fimmu.2023.1124018
dc.rights.none.fl_str_mv	cc by (c) Sans de San Nicolàs, Lídia et al., 2023 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc by (c) Sans de San Nicolàs, Lídia et al., 2023 http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	12 p. application/pdf application/pdf
dc.publisher.none.fl_str_mv	Frontiers Media SA
publisher.none.fl_str_mv	Frontiers Media SA
dc.source.none.fl_str_mv	Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients

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