Sexual hormones regulate the redox status and mitochondrial function in the brain. Pathological implications

Compared to other organs, the brain is especially exposed to oxidative stress. In general, brains from young females tend to present lower oxidative damage in comparison to their male counterparts. This has been attributed to higher antioxidant defenses and a better mitochondrial function in females...

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Detalles Bibliográficos
Autores: Torrens-Mas, Margalida, Pons, Daniel-Gabriel, Sastre-Serra, Jorge, Oliver, Jordi, Roca, Pilar
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/22893
Acceso en línea:https://hdl.handle.net/20.500.12105/22893
Access Level:acceso abierto
Palabra clave:Sex hormones
Brain
Redox homeostasis
Mitochondrial function
Aging
Sex differences
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spelling Sexual hormones regulate the redox status and mitochondrial function in the brain. Pathological implicationsTorrens-Mas, MargalidaPons, Daniel-GabrielSastre-Serra, JorgeOliver, JordiRoca, PilarSex hormonesBrainRedox homeostasisMitochondrial functionAgingSex differencesCompared to other organs, the brain is especially exposed to oxidative stress. In general, brains from young females tend to present lower oxidative damage in comparison to their male counterparts. This has been attributed to higher antioxidant defenses and a better mitochondrial function in females, which has been linked to neuroprotection in this group. However, these differences usually disappear with aging, and the incidence of brain pathologies increases in aged females. Sexual hormones, which suffer a decrease with normal aging, have been proposed as the key factors involved in these gender differences. Here, we provide an overview of redox status and mitochondrial function regulation by sexual hormones and their influence in normal brain aging. Furthermore, we discuss how sexual hormones, as well as phytoestrogens, may play an important role in the development and progression of several brain pathologies, including neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, stroke or brain cancer.Elsevier20242024-09-1320202020-04-0120202020-04-01review articlehttp://purl.org/coar/resource_type/c_dcae04bcinfo:eu-repo/semantics/articlehttps://hdl.handle.net/20.500.12105/22893reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/228932026-06-12T12:43:37Z
dc.title.none.fl_str_mv Sexual hormones regulate the redox status and mitochondrial function in the brain. Pathological implications
title Sexual hormones regulate the redox status and mitochondrial function in the brain. Pathological implications
spellingShingle Sexual hormones regulate the redox status and mitochondrial function in the brain. Pathological implications
Torrens-Mas, Margalida
Sex hormones
Brain
Redox homeostasis
Mitochondrial function
Aging
Sex differences
title_short Sexual hormones regulate the redox status and mitochondrial function in the brain. Pathological implications
title_full Sexual hormones regulate the redox status and mitochondrial function in the brain. Pathological implications
title_fullStr Sexual hormones regulate the redox status and mitochondrial function in the brain. Pathological implications
title_full_unstemmed Sexual hormones regulate the redox status and mitochondrial function in the brain. Pathological implications
title_sort Sexual hormones regulate the redox status and mitochondrial function in the brain. Pathological implications
dc.creator.none.fl_str_mv Torrens-Mas, Margalida
Pons, Daniel-Gabriel
Sastre-Serra, Jorge
Oliver, Jordi
Roca, Pilar
author Torrens-Mas, Margalida
author_facet Torrens-Mas, Margalida
Pons, Daniel-Gabriel
Sastre-Serra, Jorge
Oliver, Jordi
Roca, Pilar
author_role author
author2 Pons, Daniel-Gabriel
Sastre-Serra, Jorge
Oliver, Jordi
Roca, Pilar
author2_role author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Sex hormones
Brain
Redox homeostasis
Mitochondrial function
Aging
Sex differences
topic Sex hormones
Brain
Redox homeostasis
Mitochondrial function
Aging
Sex differences
description Compared to other organs, the brain is especially exposed to oxidative stress. In general, brains from young females tend to present lower oxidative damage in comparison to their male counterparts. This has been attributed to higher antioxidant defenses and a better mitochondrial function in females, which has been linked to neuroprotection in this group. However, these differences usually disappear with aging, and the incidence of brain pathologies increases in aged females. Sexual hormones, which suffer a decrease with normal aging, have been proposed as the key factors involved in these gender differences. Here, we provide an overview of redox status and mitochondrial function regulation by sexual hormones and their influence in normal brain aging. Furthermore, we discuss how sexual hormones, as well as phytoestrogens, may play an important role in the development and progression of several brain pathologies, including neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, stroke or brain cancer.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-04-01
2020
2020-04-01
2024
2024-09-13
dc.type.none.fl_str_mv review article
http://purl.org/coar/resource_type/c_dcae04bc
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/22893
url https://hdl.handle.net/20.500.12105/22893
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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