Caveolae - mechanosensitive membrane invaginations linked to actin filaments.

An essential property of the plasma membrane of mammalian cells is its plasticity, which is required for sensing and transmitting of signals, and for accommodating the tensional changes imposed by its environment or its own biomechanics. Caveolae are unique invaginated membrane nanodomains that play...

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Detalhes bibliográficos
Autores: Echarri, Asier, Del Pozo, Miguel A
Formato: artículo
Fecha de publicación:2015
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/17953
Acesso em linha:http://hdl.handle.net/20.500.12105/17953
Access Level:acceso abierto
Palavra-chave:Stress, Mechanical
Actomyosin
Animals
Biomechanical Phenomena
Caveolae
Cell Membrane
Humans
Mechanotransduction, Cellular
Protein Structure, Tertiary
Protein Transport
Signal Transduction
Stress Fibers
rhoA GTP-Binding Protein
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oai_identifier_str oai:repisalud.isciii.es:20.500.12105/17953
network_acronym_str ES
network_name_str España
repository_id_str
spelling Caveolae - mechanosensitive membrane invaginations linked to actin filaments.Echarri, AsierDel Pozo, Miguel AStress, MechanicalActomyosinAnimalsBiomechanical PhenomenaCaveolaeCell MembraneHumansMechanotransduction, CellularProtein Structure, TertiaryProtein TransportSignal TransductionStress FibersrhoA GTP-Binding ProteinAn essential property of the plasma membrane of mammalian cells is its plasticity, which is required for sensing and transmitting of signals, and for accommodating the tensional changes imposed by its environment or its own biomechanics. Caveolae are unique invaginated membrane nanodomains that play a major role in organizing signaling, lipid homeostasis and adaptation to membrane tension. Caveolae are frequently associated with stress fibers, a major regulator of membrane tension and cell shape. In this Commentary, we discuss recent studies that have provided new insights into the function of caveolae and have shown that trafficking and organization of caveolae are tightly regulated by stress-fiber regulators, providing a functional link between caveolae and stress fibers. Furthermore, the tension in the plasma membrane determines the curvature of caveolae because they flatten at high tension and invaginate at low tension, thus providing a tension-buffering system. Caveolae also regulate multiple cellular pathways, including RhoA-driven actomyosin contractility and other mechanosensitive pathways, suggesting that caveolae could couple mechanotransduction pathways to actin-controlled changes in tension through their association with stress fibers. Therefore, we argue here that the association of caveolae with stress fibers could provide an important strategy for cells to deal with mechanical stress.The Company of Biologists20242024-02-1220152015-08-0120152015-08-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/17953reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/179532026-06-12T12:43:37Z
dc.title.none.fl_str_mv Caveolae - mechanosensitive membrane invaginations linked to actin filaments.
title Caveolae - mechanosensitive membrane invaginations linked to actin filaments.
spellingShingle Caveolae - mechanosensitive membrane invaginations linked to actin filaments.
Echarri, Asier
Stress, Mechanical
Actomyosin
Animals
Biomechanical Phenomena
Caveolae
Cell Membrane
Humans
Mechanotransduction, Cellular
Protein Structure, Tertiary
Protein Transport
Signal Transduction
Stress Fibers
rhoA GTP-Binding Protein
title_short Caveolae - mechanosensitive membrane invaginations linked to actin filaments.
title_full Caveolae - mechanosensitive membrane invaginations linked to actin filaments.
title_fullStr Caveolae - mechanosensitive membrane invaginations linked to actin filaments.
title_full_unstemmed Caveolae - mechanosensitive membrane invaginations linked to actin filaments.
title_sort Caveolae - mechanosensitive membrane invaginations linked to actin filaments.
dc.creator.none.fl_str_mv Echarri, Asier
Del Pozo, Miguel A
author Echarri, Asier
author_facet Echarri, Asier
Del Pozo, Miguel A
author_role author
author2 Del Pozo, Miguel A
author2_role author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Stress, Mechanical
Actomyosin
Animals
Biomechanical Phenomena
Caveolae
Cell Membrane
Humans
Mechanotransduction, Cellular
Protein Structure, Tertiary
Protein Transport
Signal Transduction
Stress Fibers
rhoA GTP-Binding Protein
topic Stress, Mechanical
Actomyosin
Animals
Biomechanical Phenomena
Caveolae
Cell Membrane
Humans
Mechanotransduction, Cellular
Protein Structure, Tertiary
Protein Transport
Signal Transduction
Stress Fibers
rhoA GTP-Binding Protein
description An essential property of the plasma membrane of mammalian cells is its plasticity, which is required for sensing and transmitting of signals, and for accommodating the tensional changes imposed by its environment or its own biomechanics. Caveolae are unique invaginated membrane nanodomains that play a major role in organizing signaling, lipid homeostasis and adaptation to membrane tension. Caveolae are frequently associated with stress fibers, a major regulator of membrane tension and cell shape. In this Commentary, we discuss recent studies that have provided new insights into the function of caveolae and have shown that trafficking and organization of caveolae are tightly regulated by stress-fiber regulators, providing a functional link between caveolae and stress fibers. Furthermore, the tension in the plasma membrane determines the curvature of caveolae because they flatten at high tension and invaginate at low tension, thus providing a tension-buffering system. Caveolae also regulate multiple cellular pathways, including RhoA-driven actomyosin contractility and other mechanosensitive pathways, suggesting that caveolae could couple mechanotransduction pathways to actin-controlled changes in tension through their association with stress fibers. Therefore, we argue here that the association of caveolae with stress fibers could provide an important strategy for cells to deal with mechanical stress.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-08-01
2015
2015-08-01
2024
2024-02-12
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/17953
url http://hdl.handle.net/20.500.12105/17953
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv The Company of Biologists
publisher.none.fl_str_mv The Company of Biologists
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869403715728834560
score 15,811543

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