Traffic pollution exposure is associated with altered brain connectivity in school children.

Children are more vulnerable to the effects of environmental elements due to their active developmental processes. Exposure to urban air pollution has been associated with poorer cognitive performance, which is thought to be a result of direct interference with brain maturation. We aimed to assess t...

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Detalles Bibliográficos
Autores: Pujol Martí, Jesús, 1981-, Martínez-Vilavella, Gerard, Macià, Dídac, Fenoll, Raquel, Álvarez Pedrerol, Mar, Rivas, Ioar, Forns i Guzman, Joan, 1981-, Blanco Hinojo, Laura, 1981-, Capellades Font, Jaume, Querol, Xavier, Deus, Joan, Sunyer Deu, Jordi
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2016
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/26247
Acceso en línea:http://hdl.handle.net/10230/26247
http://dx.doi.org/10.1016/j.neuroimage.2016.01.036
Access Level:acceso abierto
Palabra clave:Aire -- Contaminació
Infants -- Desenvolupament
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spelling Traffic pollution exposure is associated with altered brain connectivity in school children.Pujol Martí, Jesús, 1981-Martínez-Vilavella, GerardMacià, DídacFenoll, RaquelÁlvarez Pedrerol, MarRivas, IoarForns i Guzman, Joan, 1981-Blanco Hinojo, Laura, 1981-Capellades Font, JaumeQuerol, XavierDeus, JoanSunyer Deu, JordiAire -- ContaminacióInfants -- DesenvolupamentChildren are more vulnerable to the effects of environmental elements due to their active developmental processes. Exposure to urban air pollution has been associated with poorer cognitive performance, which is thought to be a result of direct interference with brain maturation. We aimed to assess the extent of such potential effects of urban pollution on child brain maturation using general indicators of vehicle exhaust measured in the school environment and a comprehensive imaging evaluation. A group of 263 children, aged 8 to 12years, underwent MRI to quantify regional brain volumes, tissue composition, myelination, cortical thickness, neural tract architecture, membrane metabolites, functional connectivity in major neural networks and activation/deactivation dynamics during a sensory task. A combined measurement of elemental carbon and NO2 was used as a putative marker of vehicle exhaust. Air pollution exposure was associated with brain changes of a functional nature, with no evident effect on brain anatomy, structure or membrane metabolites. Specifically, a higher content of pollutants was associated with lower functional integration and segregation in key brain networks relevant to both inner mental processes (the default mode network) and stimulus-driven mental operations. Age and performance (motor response speed) both showed the opposite effect to that of pollution, thus indicating that higher exposure is associated with slower brain maturation. In conclusion, urban air pollution appears to adversely affect brain maturation in a critical age with changes specifically concerning the functional domain.This work was supported by the European Research Council under the ERC [grant number 268479]—the BREATHE project. The Agency of University and Research Funding Management of the Catalonia Government participated in the context of Research Group SGR2014-1673.Elsevier20162016info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/26247http://dx.doi.org/10.1016/j.neuroimage.2016.01.036reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésNeuroimage. 2016 Apr 1;129:175-84info:eu-repo/grantAgreement/EC/FP7/268479© Elsevier http://dx.doi.org/10.1016/j.neuroimage.2016.01.036info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/262472026-06-12T07:21:37Z
dc.title.none.fl_str_mv Traffic pollution exposure is associated with altered brain connectivity in school children.
title Traffic pollution exposure is associated with altered brain connectivity in school children.
spellingShingle Traffic pollution exposure is associated with altered brain connectivity in school children.
Pujol Martí, Jesús, 1981-
Aire -- Contaminació
Infants -- Desenvolupament
title_short Traffic pollution exposure is associated with altered brain connectivity in school children.
title_full Traffic pollution exposure is associated with altered brain connectivity in school children.
title_fullStr Traffic pollution exposure is associated with altered brain connectivity in school children.
title_full_unstemmed Traffic pollution exposure is associated with altered brain connectivity in school children.
title_sort Traffic pollution exposure is associated with altered brain connectivity in school children.
dc.creator.none.fl_str_mv Pujol Martí, Jesús, 1981-
Martínez-Vilavella, Gerard
Macià, Dídac
Fenoll, Raquel
Álvarez Pedrerol, Mar
Rivas, Ioar
Forns i Guzman, Joan, 1981-
Blanco Hinojo, Laura, 1981-
Capellades Font, Jaume
Querol, Xavier
Deus, Joan
Sunyer Deu, Jordi
author Pujol Martí, Jesús, 1981-
author_facet Pujol Martí, Jesús, 1981-
Martínez-Vilavella, Gerard
Macià, Dídac
Fenoll, Raquel
Álvarez Pedrerol, Mar
Rivas, Ioar
Forns i Guzman, Joan, 1981-
Blanco Hinojo, Laura, 1981-
Capellades Font, Jaume
Querol, Xavier
Deus, Joan
Sunyer Deu, Jordi
author_role author
author2 Martínez-Vilavella, Gerard
Macià, Dídac
Fenoll, Raquel
Álvarez Pedrerol, Mar
Rivas, Ioar
Forns i Guzman, Joan, 1981-
Blanco Hinojo, Laura, 1981-
Capellades Font, Jaume
Querol, Xavier
Deus, Joan
Sunyer Deu, Jordi
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Aire -- Contaminació
Infants -- Desenvolupament
topic Aire -- Contaminació
Infants -- Desenvolupament
description Children are more vulnerable to the effects of environmental elements due to their active developmental processes. Exposure to urban air pollution has been associated with poorer cognitive performance, which is thought to be a result of direct interference with brain maturation. We aimed to assess the extent of such potential effects of urban pollution on child brain maturation using general indicators of vehicle exhaust measured in the school environment and a comprehensive imaging evaluation. A group of 263 children, aged 8 to 12years, underwent MRI to quantify regional brain volumes, tissue composition, myelination, cortical thickness, neural tract architecture, membrane metabolites, functional connectivity in major neural networks and activation/deactivation dynamics during a sensory task. A combined measurement of elemental carbon and NO2 was used as a putative marker of vehicle exhaust. Air pollution exposure was associated with brain changes of a functional nature, with no evident effect on brain anatomy, structure or membrane metabolites. Specifically, a higher content of pollutants was associated with lower functional integration and segregation in key brain networks relevant to both inner mental processes (the default mode network) and stimulus-driven mental operations. Age and performance (motor response speed) both showed the opposite effect to that of pollution, thus indicating that higher exposure is associated with slower brain maturation. In conclusion, urban air pollution appears to adversely affect brain maturation in a critical age with changes specifically concerning the functional domain.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/26247
http://dx.doi.org/10.1016/j.neuroimage.2016.01.036
url http://hdl.handle.net/10230/26247
http://dx.doi.org/10.1016/j.neuroimage.2016.01.036
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Neuroimage. 2016 Apr 1;129:175-84
info:eu-repo/grantAgreement/EC/FP7/268479
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1016/j.neuroimage.2016.01.036
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1016/j.neuroimage.2016.01.036
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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