Anti-Müllerian hormone does not predict cumulative pregnancy rate in non-infertile women following four IUI cycles with donor sperm

Purpose: To evaluate the predictive value of serum AMH for clinical pregnancy in non-infertile population undergoing intrauterine insemination with donor sperm (ds-IUI). Methods: This multicenter prospective study (ClinicalTrials.gov ID: NCT06263192) recruited all non-infertile women undergoing ds-I...

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Autores: Gayete Lafuente, Sònia|||0000-0002-7375-5848, Moreno-Sepulveda, José|||0000-0002-4921-1162, Sánchez-Álvarez, Javier, Prat Grau, Maria|||0000-0002-3811-9205, Robles, Ana, Espinós, Juan José|||0000-0003-4838-8940, Checa, Miguel Angel|||0000-0002-0226-3416
Tipo de documento: artigo
Data de publicação:2024
País:España
Recursos:Universitat Autònoma de Barcelona
Repositório:Dipòsit Digital de Documents de la UAB
Idioma:inglês
OAI Identifier:oai:ddd.uab.cat:318147
Acesso em linha:https://ddd.uab.cat/record/318147
https://dx.doi.org/urn:doi:10.1007/s10815-024-03188-5
Access Level:Acceso aberto
Palavra-chave:AMH
Anti-Müllerian hormone
Cumulative pregnancy rate
IUI
Intrauterine insemination
Predictive value
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spelling Anti-Müllerian hormone does not predict cumulative pregnancy rate in non-infertile women following four IUI cycles with donor spermGayete Lafuente, Sònia|||0000-0002-7375-5848Moreno-Sepulveda, José|||0000-0002-4921-1162Sánchez-Álvarez, JavierPrat Grau, Maria|||0000-0002-3811-9205Robles, AnaEspinós, Juan José|||0000-0003-4838-8940Checa, Miguel Angel|||0000-0002-0226-3416AMHAnti-Müllerian hormoneCumulative pregnancy rateIUIIntrauterine inseminationPredictive valuePurpose: To evaluate the predictive value of serum AMH for clinical pregnancy in non-infertile population undergoing intrauterine insemination with donor sperm (ds-IUI). Methods: This multicenter prospective study (ClinicalTrials.gov ID: NCT06263192) recruited all non-infertile women undergoing ds-IUI from June 2020 to December 2022 in three different fertility clinics in Spain and Chile. Indications for ds-IUI included severe oligoasthenoteratozoospermia, female partner, or single status. Clinical pregnancy rates were compared between women with AMH ≥ 1.1 and < 1.1 ng/mL. The main outcome measure was the cumulative clinical pregnancy rate after up to 4 ds-IUI cycles. Results: A total of 458 ds-IUI cycles were performed among 245 patients, of whom 108 (44.08%) achieved clinical pregnancy within 4 cycles, 60.2% of these occurring in the first attempt and 84.2% after two attempts. We found no significant differences in AMH levels or other parameters (such as age, BMI, FSH, AFC) between women who became pregnant and those who did not. Cumulative pregnancy rates and logistic regression analysis revealed that AMH ≥ 1.1 ng/mL was not predictive of ds-IUI success. While a high positive correlation was observed between AFC and AMH (r = 0.67, p < 0.001), ROC curve analyses indicated that neither of these ovarian reserve markers accurately forecasts cumulative ds-IUI outcomes in non-infertile women. Conclusions: The findings of this multicenter study suggest that AMH is not a reliable predictor of pregnancy in non-infertile women undergoing ds-IUI. Even women with low AMH levels can achieve successful pregnancy outcomes, supporting the notion that diminished ovarian reserve should not restrict access to ds-IUI treatments in eligible non-infertile women. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/318147https://dx.doi.org/urn:doi:10.1007/s10815-024-03188-5reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3181472026-06-06T12:50:31Z
dc.title.none.fl_str_mv Anti-Müllerian hormone does not predict cumulative pregnancy rate in non-infertile women following four IUI cycles with donor sperm
title Anti-Müllerian hormone does not predict cumulative pregnancy rate in non-infertile women following four IUI cycles with donor sperm
spellingShingle Anti-Müllerian hormone does not predict cumulative pregnancy rate in non-infertile women following four IUI cycles with donor sperm
Gayete Lafuente, Sònia|||0000-0002-7375-5848
AMH
Anti-Müllerian hormone
Cumulative pregnancy rate
IUI
Intrauterine insemination
Predictive value
title_short Anti-Müllerian hormone does not predict cumulative pregnancy rate in non-infertile women following four IUI cycles with donor sperm
title_full Anti-Müllerian hormone does not predict cumulative pregnancy rate in non-infertile women following four IUI cycles with donor sperm
title_fullStr Anti-Müllerian hormone does not predict cumulative pregnancy rate in non-infertile women following four IUI cycles with donor sperm
title_full_unstemmed Anti-Müllerian hormone does not predict cumulative pregnancy rate in non-infertile women following four IUI cycles with donor sperm
title_sort Anti-Müllerian hormone does not predict cumulative pregnancy rate in non-infertile women following four IUI cycles with donor sperm
dc.creator.none.fl_str_mv Gayete Lafuente, Sònia|||0000-0002-7375-5848
Moreno-Sepulveda, José|||0000-0002-4921-1162
Sánchez-Álvarez, Javier
Prat Grau, Maria|||0000-0002-3811-9205
Robles, Ana
Espinós, Juan José|||0000-0003-4838-8940
Checa, Miguel Angel|||0000-0002-0226-3416
author Gayete Lafuente, Sònia|||0000-0002-7375-5848
author_facet Gayete Lafuente, Sònia|||0000-0002-7375-5848
Moreno-Sepulveda, José|||0000-0002-4921-1162
Sánchez-Álvarez, Javier
Prat Grau, Maria|||0000-0002-3811-9205
Robles, Ana
Espinós, Juan José|||0000-0003-4838-8940
Checa, Miguel Angel|||0000-0002-0226-3416
author_role author
author2 Moreno-Sepulveda, José|||0000-0002-4921-1162
Sánchez-Álvarez, Javier
Prat Grau, Maria|||0000-0002-3811-9205
Robles, Ana
Espinós, Juan José|||0000-0003-4838-8940
Checa, Miguel Angel|||0000-0002-0226-3416
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv AMH
Anti-Müllerian hormone
Cumulative pregnancy rate
IUI
Intrauterine insemination
Predictive value
topic AMH
Anti-Müllerian hormone
Cumulative pregnancy rate
IUI
Intrauterine insemination
Predictive value
description Purpose: To evaluate the predictive value of serum AMH for clinical pregnancy in non-infertile population undergoing intrauterine insemination with donor sperm (ds-IUI). Methods: This multicenter prospective study (ClinicalTrials.gov ID: NCT06263192) recruited all non-infertile women undergoing ds-IUI from June 2020 to December 2022 in three different fertility clinics in Spain and Chile. Indications for ds-IUI included severe oligoasthenoteratozoospermia, female partner, or single status. Clinical pregnancy rates were compared between women with AMH ≥ 1.1 and < 1.1 ng/mL. The main outcome measure was the cumulative clinical pregnancy rate after up to 4 ds-IUI cycles. Results: A total of 458 ds-IUI cycles were performed among 245 patients, of whom 108 (44.08%) achieved clinical pregnancy within 4 cycles, 60.2% of these occurring in the first attempt and 84.2% after two attempts. We found no significant differences in AMH levels or other parameters (such as age, BMI, FSH, AFC) between women who became pregnant and those who did not. Cumulative pregnancy rates and logistic regression analysis revealed that AMH ≥ 1.1 ng/mL was not predictive of ds-IUI success. While a high positive correlation was observed between AFC and AMH (r = 0.67, p < 0.001), ROC curve analyses indicated that neither of these ovarian reserve markers accurately forecasts cumulative ds-IUI outcomes in non-infertile women. Conclusions: The findings of this multicenter study suggest that AMH is not a reliable predictor of pregnancy in non-infertile women undergoing ds-IUI. Even women with low AMH levels can achieve successful pregnancy outcomes, supporting the notion that diminished ovarian reserve should not restrict access to ds-IUI treatments in eligible non-infertile women.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/318147
https://dx.doi.org/urn:doi:10.1007/s10815-024-03188-5
url https://ddd.uab.cat/record/318147
https://dx.doi.org/urn:doi:10.1007/s10815-024-03188-5
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
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eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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