Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: a randomised, double-blind, placebo-controlled study in Spanish iron-deficient women

Iron deficiency anaemia is a worldwide health problem. We studied the influence of consuming an iron fortified fruit juice on iron status in menstruating women. A randomised double-blind placebo-controlled study of 16-weeks of duration was performed. Two groups: P group (n=58) or F group (n=64) cons...

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Autores: Blanco-Rojo, Ruth, Pérez Granados, Ana M., Toxqui, Laura, González-Vizcayno, Carmen, Delgado, Marco A., Vaquero, M. Pilar
Tipo de recurso: artículo
Fecha de publicación:2011
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/32822
Acceso en línea:http://hdl.handle.net/10261/32822
Access Level:acceso abierto
Palabra clave:Fortifications
Ferric pyrophosphate
iron-deficiency anaemia
iron status
Women
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spelling Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: a randomised, double-blind, placebo-controlled study in Spanish iron-deficient womenBlanco-Rojo, RuthPérez Granados, Ana M.Toxqui, LauraGonzález-Vizcayno, CarmenDelgado, Marco A.Vaquero, M. PilarFortificationsFerric pyrophosphateiron-deficiency anaemiairon statusWomenIron deficiency anaemia is a worldwide health problem. We studied the influence of consuming an iron fortified fruit juice on iron status in menstruating women. A randomised double-blind placebo-controlled study of 16-weeks of duration was performed. Two groups: P group (n=58) or F group (n=64) consumed, as a supplement to their usual diet, 500 mL/day of placebo fruit juice or iron-fortified fruit juice, respectively. The iron fortified-juice, containing microencapsulated iron pyrophosphate, provided 18 mg of iron (100% of the recommended dietary allowance per day). At baseline and monthly, dietary intake, body weight, and iron parameters were determined: total red blood cells, haematocrit, mean corpuscular volume (MCV), red blood cell distribution width (RDW), haemoglobin, serum iron, serum ferritin, serum transferrin, transferrin saturation, soluble transferrin receptor (sTfR-2), and zinc protoporphyrin (ZnPP). The fruit juices consumption involved increased intake of carbohydrates and vitamin C, and increased body mass index within normal limits. Ferritin was higher in F after week 4 (p<0•05) and became 80% higher than in P after week 16 (p<0•001), and transferrin decreased in F group compared to P group after week 4 (p<0•001). RDW was higher at weeks 4 and 8 in F compared to P (p<0•05). Transferrin saturation increased after week 8, and haematocrit, MCV, and haemoglobin increased after week 12, in F compared to P. Serum iron did not change. sTfR and ZnPP decreased in F at week 16 (p<0•05). Iron pyrophosphate fortified fruit juice improves iron status and may be used to prevent iron deficiency anaemia. This trial was register at clinicaltrials.gov as NCT01135576.Supported by Grupo Leche Pascual and Projects Ref. AGL2006 09519/ALI and Ref. AGL2009 11437.Peer reviewed201120112011info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/32822reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés10.1017/S0007114510005490info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/328222026-05-22T06:33:51Z
dc.title.none.fl_str_mv Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: a randomised, double-blind, placebo-controlled study in Spanish iron-deficient women
title Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: a randomised, double-blind, placebo-controlled study in Spanish iron-deficient women
spellingShingle Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: a randomised, double-blind, placebo-controlled study in Spanish iron-deficient women
Blanco-Rojo, Ruth
Fortifications
Ferric pyrophosphate
iron-deficiency anaemia
iron status
Women
title_short Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: a randomised, double-blind, placebo-controlled study in Spanish iron-deficient women
title_full Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: a randomised, double-blind, placebo-controlled study in Spanish iron-deficient women
title_fullStr Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: a randomised, double-blind, placebo-controlled study in Spanish iron-deficient women
title_full_unstemmed Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: a randomised, double-blind, placebo-controlled study in Spanish iron-deficient women
title_sort Efficacy of a microencapsulated iron pyrophosphate-fortified fruit juice: a randomised, double-blind, placebo-controlled study in Spanish iron-deficient women
dc.creator.none.fl_str_mv Blanco-Rojo, Ruth
Pérez Granados, Ana M.
Toxqui, Laura
González-Vizcayno, Carmen
Delgado, Marco A.
Vaquero, M. Pilar
author Blanco-Rojo, Ruth
author_facet Blanco-Rojo, Ruth
Pérez Granados, Ana M.
Toxqui, Laura
González-Vizcayno, Carmen
Delgado, Marco A.
Vaquero, M. Pilar
author_role author
author2 Pérez Granados, Ana M.
Toxqui, Laura
González-Vizcayno, Carmen
Delgado, Marco A.
Vaquero, M. Pilar
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Fortifications
Ferric pyrophosphate
iron-deficiency anaemia
iron status
Women
topic Fortifications
Ferric pyrophosphate
iron-deficiency anaemia
iron status
Women
description Iron deficiency anaemia is a worldwide health problem. We studied the influence of consuming an iron fortified fruit juice on iron status in menstruating women. A randomised double-blind placebo-controlled study of 16-weeks of duration was performed. Two groups: P group (n=58) or F group (n=64) consumed, as a supplement to their usual diet, 500 mL/day of placebo fruit juice or iron-fortified fruit juice, respectively. The iron fortified-juice, containing microencapsulated iron pyrophosphate, provided 18 mg of iron (100% of the recommended dietary allowance per day). At baseline and monthly, dietary intake, body weight, and iron parameters were determined: total red blood cells, haematocrit, mean corpuscular volume (MCV), red blood cell distribution width (RDW), haemoglobin, serum iron, serum ferritin, serum transferrin, transferrin saturation, soluble transferrin receptor (sTfR-2), and zinc protoporphyrin (ZnPP). The fruit juices consumption involved increased intake of carbohydrates and vitamin C, and increased body mass index within normal limits. Ferritin was higher in F after week 4 (p<0•05) and became 80% higher than in P after week 16 (p<0•001), and transferrin decreased in F group compared to P group after week 4 (p<0•001). RDW was higher at weeks 4 and 8 in F compared to P (p<0•05). Transferrin saturation increased after week 8, and haematocrit, MCV, and haemoglobin increased after week 12, in F compared to P. Serum iron did not change. sTfR and ZnPP decreased in F at week 16 (p<0•05). Iron pyrophosphate fortified fruit juice improves iron status and may be used to prevent iron deficiency anaemia. This trial was register at clinicaltrials.gov as NCT01135576.
publishDate 2011
dc.date.none.fl_str_mv 2011
2011
2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
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dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/32822
url http://hdl.handle.net/10261/32822
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv 10.1017/S0007114510005490
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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